PMID- 28128064
OWN - NLM
STAT- MEDLINE
DCOM- 20171212
LR  - 20171212
IS  - 1875-6212 (Electronic)
IS  - 1570-1611 (Linking)
VI  - 15
IP  - 3
DP  - 2017
TI  - Platelets and Platelet-Derived Microvesicles as Immune Effectors in Type 2 
      Diabetes.
PG  - 207-217
LID - 10.2174/1570161115666170126130309 [doi]
AB  - The association between type 2 diabetes mellitus (T2DM) and systemic inflammation 
      may increase platelet reactivity and the accelerated development of vascular 
      disease. Platelets are able to modulate the function of immune cells via the 
      direct release of growth factors and pro-inflammatory chemokines through the 
      production of microvesicles. The microvesicles trigger a transcellular delivery 
      system of bioactive molecules to other cells acting as vectors in the exchange of 
      biological information. Here, we consider the influence of platelets and 
      platelet-derived microvesicles on cells of the immune system and the implications 
      in the pathogenesis of T2DM.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Cortez-Espinosa, Nancy
AU  - Cortez-Espinosa N
AD  - Centro de Investigacion Facultad de Medicina-UNAM-UABJO, Oaxaca, Mexico.
FAU - Mayoral, Laura Perez-Campos
AU  - Mayoral LP
AD  - Department of Investigation Medicine-UNAM-UABJO, Faculty of School of Medicine, 
      UABJO University, CP 60120, Oaxaca, Mexico.
FAU - Perez-Campos, Eduardo
AU  - Perez-Campos E
AD  - Centro de Investigacion Facultad de Medicina-UNAM-UABJO, Oaxaca, Mexico.
FAU - Cabrera Fuentes, Hector Alejandro
AU  - Cabrera Fuentes HA
AD  - Cardiovascular & Metabolic Diseases Program Duke-NUS Graduate Medical School 
      Singapore, Singapore.
FAU - Mayoral, Eduardo Perez-Campos
AU  - Mayoral EP
AD  - Centro de Investigacion Facultad de Medicina-UNAM-UABJO, Oaxaca, Mexico.
FAU - Martinez-Cruz, Ruth
AU  - Martinez-Cruz R
AD  - Centro de Investigacion Facultad de Medicina-UNAM-UABJO, Oaxaca, Mexico.
FAU - Canseco, Socorro Pina
AU  - Canseco SP
AD  - Centro de Investigacion Facultad de Medicina-UNAM-UABJO, Oaxaca, Mexico.
FAU - Andrade, Gabriel Mayoral
AU  - Andrade GM
AD  - Centro de Investigacion Facultad de Medicina-UNAM-UABJO, Oaxaca, Mexico.
FAU - Cruz, Margarito Martinez
AU  - Cruz MM
AD  - Unidad de Bioquimica e Inmunologia, ITO-UNAM, Oaxaca, Mexico.
FAU - Velasco, Itandehui Gallegos
AU  - Velasco IG
AD  - Centro de Investigacion Facultad de Medicina-UNAM-UABJO, Oaxaca, Mexico.
FAU - Cruz, Pedro Hernandez
AU  - Cruz PH
AD  - Centro de Investigacion Facultad de Medicina-UNAM-UABJO, Oaxaca, Mexico.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Vasc Pharmacol
JT  - Current vascular pharmacology
JID - 101157208
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Adaptive Immunity
MH  - Animals
MH  - Blood Platelets/*immunology/metabolism
MH  - Cell-Derived Microparticles/*immunology/metabolism
MH  - Diabetes Mellitus, Type 2/blood/*immunology
MH  - Humans
MH  - Immunity, Innate
MH  - Inflammation Mediators/blood/immunology
MH  - Oxidative Stress
MH  - Signal Transduction
OTO - NOTNLM
OT  - Platelets
OT  - diabetes
OT  - effectors
OT  - immune
OT  - inflammation
OT  - microvesicles
EDAT- 2017/01/28 06:00
MHDA- 2017/12/13 06:00
CRDT- 2017/01/28 06:00
PHST- 2016/09/12 00:00 [received]
PHST- 2016/12/30 00:00 [revised]
PHST- 2016/12/30 00:00 [accepted]
PHST- 2017/01/28 06:00 [pubmed]
PHST- 2017/12/13 06:00 [medline]
PHST- 2017/01/28 06:00 [entrez]
AID - CVP-EPUB-81298 [pii]
AID - 10.2174/1570161115666170126130309 [doi]
PST - ppublish
SO  - Curr Vasc Pharmacol. 2017;15(3):207-217. doi: 10.2174/1570161115666170126130309.