PMID- 28131178
OWN - NLM
STAT- MEDLINE
DCOM- 20170602
LR  - 20171210
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 373
DP  - 2017 Feb 15
TI  - Cortical control of vertical and horizontal saccades in progressive supranuclear 
      palsy: An exploratory fMRI study.
PG  - 157-166
LID - S0022-510X(16)30842-5 [pii]
LID - 10.1016/j.jns.2016.12.049 [doi]
AB  - Progressive supranuclear palsy (PSP) is a neurodegenerative disorder showing 
      predominant brainstem involvement, characterized by marked slowing of rapid eye 
      movements (saccades), particularly along the vertical plane. While the 
      contribution of the brainstem damage for the saccadic disturbance in PSP has been 
      extensively studied, much less is known about its cortical and subcortical 
      pathomechanisms. We measured reflexive (prosaccades) and voluntary (antisaccades) 
      saccades in the vertical and horizontal plane in PSP patients (n=8) and controls 
      (n=10) in an eye tracking study, followed by the measurement of blood 
      oxygenation-level dependent (BOLD) activation (PSP, n=6; controls, n=10) during 
      similar saccade paradigms. Behaviorally, PSP patients evidenced slower and lower 
      amplitude prosaccades (horizontal and vertical) and lower amplitude antisaccades 
      (vertical) than controls. Functionally, patients showed decreased frontostriatal 
      BOLD activation during prosaccades (horizontal and vertical) and antisaccades 
      (vertical), relative to controls. Additionally, PSP patients showed less default 
      mode network (DMN) deactivation than controls for all types of saccades. Within 
      groups, controls showed no BOLD differences between horizontal and vertical 
      prosaccades while PSP patients demonstrated greater DMN deactivation during 
      vertical prosaccades. Both groups evidenced greater DMN deactivation during 
      vertical antisaccades when compared to their horizontal counterpart and patients 
      further showed relative frontostriatal BOLD hypoactivity during vertical 
      antisaccades. We found fMRI evidence of frontostriatal hypoactivity in PSP 
      patients relative to controls, especially during vertical saccades. These new 
      findings highlight the impact of cortical impairment in saccadic disturbance of 
      PSP.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Lemos, J
AU  - Lemos J
AD  - Neurology Department, Coimbra University Hospital Center, Coimbra, Portugal. 
      Electronic address: merrin72@hotmail.com.
FAU - Pereira, D
AU  - Pereira D
AD  - Neuroradiology Department, Coimbra University Hospital Center, Coimbra, Portugal; 
      Institute of Nuclear Sciences Applied to Health (ICNAS), Institute for Biomedical 
      Imaging and Life Sciences (CNC.IBILI), Coimbra, Portugal.
FAU - Almendra, L
AU  - Almendra L
AD  - Neurology Department, Coimbra University Hospital Center, Coimbra, Portugal.
FAU - Rebelo, D
AU  - Rebelo D
AD  - Institute of Nuclear Sciences Applied to Health (ICNAS), Institute for Biomedical 
      Imaging and Life Sciences (CNC.IBILI), Coimbra, Portugal.
FAU - Patricio, M
AU  - Patricio M
AD  - Laboratory of Biostatistics and Medical Informatics, Health/Institute for 
      Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, 
      Coimbra, Portugal.
FAU - Castelhano, J
AU  - Castelhano J
AD  - Institute of Nuclear Sciences Applied to Health (ICNAS), Institute for Biomedical 
      Imaging and Life Sciences (CNC.IBILI), Coimbra, Portugal.
FAU - Cunha, G
AU  - Cunha G
AD  - Neuroradiology Department, Coimbra University Hospital Center, Coimbra, Portugal; 
      Institute of Nuclear Sciences Applied to Health (ICNAS), Institute for Biomedical 
      Imaging and Life Sciences (CNC.IBILI), Coimbra, Portugal.
FAU - Januario, C
AU  - Januario C
AD  - Neurology Department, Coimbra University Hospital Center, Coimbra, Portugal; 
      Faculty of Medicine, Coimbra University, Coimbra, Portugal.
FAU - Cunha, L
AU  - Cunha L
AD  - Neurology Department, Coimbra University Hospital Center, Coimbra, Portugal; 
      Faculty of Medicine, Coimbra University, Coimbra, Portugal.
FAU - Freire, A
AU  - Freire A
AD  - Neurology Department, Coimbra University Hospital Center, Coimbra, Portugal; 
      Faculty of Medicine, Coimbra University, Coimbra, Portugal.
FAU - Castelo-Branco, M
AU  - Castelo-Branco M
AD  - Institute of Nuclear Sciences Applied to Health (ICNAS), Institute for Biomedical 
      Imaging and Life Sciences (CNC.IBILI), Coimbra, Portugal; Faculty of Medicine, 
      Coimbra University, Coimbra, Portugal.
LA  - eng
PT  - Journal Article
DEP - 20161227
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain Mapping
MH  - Cerebral Cortex/diagnostic imaging/*physiopathology
MH  - Cerebrovascular Circulation/physiology
MH  - Eye Movement Measurements
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neural Pathways/diagnostic imaging/physiopathology
MH  - Neuropsychological Tests
MH  - Oxygen/blood
MH  - Saccades/*physiology
MH  - Supranuclear Palsy, Progressive/diagnostic imaging/*physiopathology
OTO - NOTNLM
OT  - Basal ganglia
OT  - Eye movement measurements
OT  - Functional MRI
OT  - Progressive supranuclear palsy
OT  - Saccades
EDAT- 2017/01/31 06:00
MHDA- 2017/06/03 06:00
CRDT- 2017/01/30 06:00
PHST- 2016/06/22 00:00 [received]
PHST- 2016/11/25 00:00 [revised]
PHST- 2016/12/23 00:00 [accepted]
PHST- 2017/01/30 06:00 [entrez]
PHST- 2017/01/31 06:00 [pubmed]
PHST- 2017/06/03 06:00 [medline]
AID - S0022-510X(16)30842-5 [pii]
AID - 10.1016/j.jns.2016.12.049 [doi]
PST - ppublish
SO  - J Neurol Sci. 2017 Feb 15;373:157-166. doi: 10.1016/j.jns.2016.12.049. Epub 2016 
      Dec 27.