PMID- 28131195
OWN - NLM
STAT- MEDLINE
DCOM- 20170602
LR  - 20171210
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 373
DP  - 2017 Feb 15
TI  - Disease progression and oxidative stress are associated with higher serum 
      ferritin levels in patients with multiple sclerosis.
PG  - 236-241
LID - S0022-510X(16)30832-2 [pii]
LID - 10.1016/j.jns.2016.12.039 [doi]
AB  - Hyperferritinemia and oxidative stress have been implicated in the pathogenesis 
      of multiple sclerosis (MS). The aim of the present study was to evaluate the 
      serum levels of ferritin and to verify their association with oxidative stress 
      markers and MS progression. This study included 164 MS patients, which were 
      divided in two groups according to their levels of ferritin (cut off 125.6mug/L). 
      Oxidative stress was evaluated by tert-butyl hydroperoxide-initiated 
      chemiluminescence (CL-LOOH), advanced oxidation protein products (AOPP), carbonyl 
      protein, nitric oxide metabolites (NO(x)), sulfhydryl groups of protein and total 
      radical-trapping antioxidant parameter (TRAP). MS patients with elevated levels 
      of ferritin showed higher disease progression (p=0.030), AOPP (p=0.001), and 
      lower plasma NO(x) levels (p=0.031) and TRAP (p=0.006) than MS patients with 
      lower ferritin levels. The multivariate binary logistic regression analysis 
      showed that increased AOPP and progression of disease were significantly and 
      positively associated with increase of ferritin. The combination of serum 
      ferritin levels and oxidative stress markers were responsible for 13,9% in the 
      disease progression. In conclusion, our results suggest that ferritin could 
      aggravate oxidative stress in patients with MS and contribute to progression of 
      disease.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Ferreira, Katerine Panichi Zanin
AU  - Ferreira KPZ
AD  - Postgraduate Program, Biological Sciences Center, University of Londrina, Parana, 
      Brazil.
FAU - Oliveira, Sayonara R
AU  - Oliveira SR
AD  - Department of Pathology, Clinical Analysis and Toxicology, Health Sciences 
      Center, University of Londrina, Parana, Brazil.
FAU - Kallaur, Ana Paula
AU  - Kallaur AP
AD  - Postgraduate Program, Biological Sciences Center, University of Londrina, Parana, 
      Brazil.
FAU - Kaimen-Maciel, Damacio R
AU  - Kaimen-Maciel DR
AD  - Department of Internal Medicine, University of Londrina, Londrina, Parana, 
      Brazil.
FAU - Lozovoy, Marcell Alysson B
AU  - Lozovoy MAB
AD  - Department of Pathology, Clinical Analysis and Toxicology, Health Sciences 
      Center, University of Londrina, Parana, Brazil.
FAU - de Almeida, Elaine Regina Delicato
AU  - de Almeida ERD
AD  - Department of Pathology, Clinical Analysis and Toxicology, Health Sciences 
      Center, University of Londrina, Parana, Brazil.
FAU - Morimoto, Helena Kaminami
AU  - Morimoto HK
AD  - Department of Pathology, Clinical Analysis and Toxicology, Health Sciences 
      Center, University of Londrina, Parana, Brazil.
FAU - Mezzaroba, Leda
AU  - Mezzaroba L
AD  - Department of Pathology, Clinical Analysis and Toxicology, Health Sciences 
      Center, University of Londrina, Parana, Brazil.
FAU - Dichi, Isaias
AU  - Dichi I
AD  - Department of Internal Medicine, University of Londrina, Londrina, Parana, 
      Brazil.
FAU - Reiche, Edna Maria Vissoci
AU  - Reiche EMV
AD  - Department of Pathology, Clinical Analysis and Toxicology, Health Sciences 
      Center, University of Londrina, Parana, Brazil.
FAU - Simao, Andrea Name Colado
AU  - Simao ANC
AD  - Department of Pathology, Clinical Analysis and Toxicology, Health Sciences 
      Center, University of Londrina, Parana, Brazil. Electronic address: 
      deianame@yahoo.com.br.
LA  - eng
PT  - Journal Article
DEP - 20161227
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Biomarkers)
RN  - 0 (Immunologic Factors)
RN  - 9007-73-2 (Ferritins)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Disability Evaluation
MH  - Disease Progression
MH  - Female
MH  - Ferritins/*blood
MH  - Humans
MH  - Immunologic Factors/therapeutic use
MH  - Iron/blood
MH  - Logistic Models
MH  - Luminescence
MH  - Male
MH  - Multiple Sclerosis/*blood/drug therapy
MH  - Multivariate Analysis
MH  - Oxidative Stress/*physiology
MH  - Smoking/blood
OTO - NOTNLM
OT  - Disease progression
OT  - Ferritin
OT  - Hyperferritinemia
OT  - Multiple sclerosis
OT  - Oxidative stress
EDAT- 2017/01/31 06:00
MHDA- 2017/06/03 06:00
CRDT- 2017/01/30 06:00
PHST- 2016/09/27 00:00 [received]
PHST- 2016/12/06 00:00 [revised]
PHST- 2016/12/21 00:00 [accepted]
PHST- 2017/01/30 06:00 [entrez]
PHST- 2017/01/31 06:00 [pubmed]
PHST- 2017/06/03 06:00 [medline]
AID - S0022-510X(16)30832-2 [pii]
AID - 10.1016/j.jns.2016.12.039 [doi]
PST - ppublish
SO  - J Neurol Sci. 2017 Feb 15;373:236-241. doi: 10.1016/j.jns.2016.12.039. Epub 2016 
      Dec 27.