PMID- 28131588
OWN - NLM
STAT- MEDLINE
DCOM- 20170414
LR  - 20221207
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1487
DP  - 2017 Mar 3
TI  - Simplified solid-phase extraction procedure combined with liquid chromatography 
      tandem-mass spectrometry for multiresidue assessment of pharmaceutical compounds 
      in environmental liquid samples.
PG  - 54-63
LID - S0021-9673(17)30144-9 [pii]
LID - 10.1016/j.chroma.2017.01.059 [doi]
AB  - To follow the twelve "green analytical chemistry" (GAC) principles, it is 
      necessary to continuously develop analytical extraction and determination 
      methodologies to assess the presence of micropollutants, such as pharmaceuticals, 
      in environmental samples. A reduction in the analysis time and solvent quantity, 
      which is one of the GAC principles, has been achieved through a simplified 
      solid-phase extraction (SPE) procedure combined with high-performance liquid 
      chromatography-tandem mass spectrometry (LC-MS/MS) for the determination of 
      twenty-three pharmaceuticals in liquid environmental samples using 
      N-vinylpyrrolidone-divinylbenzene copolymer (OASIS HLB) cartridges. The optimal 
      SPE conditions were studied. In these optimized conditions, 82.6% of the data 
      have a median recovery above 70% for all compounds in each sample. The relative 
      standard deviations (RSDs) were below 14.4% and 22.0% for intra- and inter-day 
      repeatability, respectively. Method detection limits (MDLs) and method 
      quantification limits (MQLs) ranged from 0.011 to 188ngL(-1) and from 0.033 to 
      628ngL(-1), respectively. The applicability of the method was evaluated in real 
      samples from natural and conventional wastewater treatment plants (WWTPs), and 
      results were obtained in concentration ranges from 0.013 to 91.5mugL(-1) and from 
      0.004 to 49.1mugL(-1), respectively.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Afonso-Olivares, C
AU  - Afonso-Olivares C
AD  - Instituto Universitario de Estudios Ambientales y Recursos Naturales (i-UNAT), 
      Universidad de Las Palmas de Gran Canaria, 35017 Las Palmas de Gran Canaria, 
      Spain.
FAU - Cadkova, T
AU  - Cadkova T
AD  - Department of Analytical Chemistry, Faculty of Pharmacy, Charles University, 
      Heyrovskeho 1203, 500 05 Hradec Kralove, Czechia.
FAU - Sosa-Ferrera, Z
AU  - Sosa-Ferrera Z
AD  - Instituto Universitario de Estudios Ambientales y Recursos Naturales (i-UNAT), 
      Universidad de Las Palmas de Gran Canaria, 35017 Las Palmas de Gran Canaria, 
      Spain.
FAU - Santana-Rodriguez, J J
AU  - Santana-Rodriguez JJ
AD  - Instituto Universitario de Estudios Ambientales y Recursos Naturales (i-UNAT), 
      Universidad de Las Palmas de Gran Canaria, 35017 Las Palmas de Gran Canaria, 
      Spain. Electronic address: josejuan.santana@ulpgc.es.
FAU - Novakova, L
AU  - Novakova L
AD  - Department of Analytical Chemistry, Faculty of Pharmacy, Charles University, 
      Heyrovskeho 1203, 500 05 Hradec Kralove, Czechia.
LA  - eng
PT  - Journal Article
DEP - 20170123
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Waste Water)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Chromatography, Liquid
MH  - Environmental Monitoring/*methods
MH  - Fresh Water/chemistry
MH  - Limit of Detection
MH  - Pharmaceutical Preparations/*analysis/isolation & purification
MH  - *Solid Phase Extraction
MH  - *Tandem Mass Spectrometry
MH  - Wastewater/chemistry
MH  - Water Pollutants, Chemical/analysis/isolation & purification
OTO - NOTNLM
OT  - High-performance liquid chromatography-tandem mass spectrometry
OT  - Pharmaceuticals
OT  - Simplified solid-phase extraction
OT  - Wastewater
EDAT- 2017/01/31 06:00
MHDA- 2017/04/15 06:00
CRDT- 2017/01/30 06:00
PHST- 2016/12/15 00:00 [received]
PHST- 2017/01/20 00:00 [revised]
PHST- 2017/01/23 00:00 [accepted]
PHST- 2017/01/31 06:00 [pubmed]
PHST- 2017/04/15 06:00 [medline]
PHST- 2017/01/30 06:00 [entrez]
AID - S0021-9673(17)30144-9 [pii]
AID - 10.1016/j.chroma.2017.01.059 [doi]
PST - ppublish
SO  - J Chromatogr A. 2017 Mar 3;1487:54-63. doi: 10.1016/j.chroma.2017.01.059. Epub 
      2017 Jan 23.