PMID- 28131673
OWN - NLM
STAT- MEDLINE
DCOM- 20170307
LR  - 20180816
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 466
DP  - 2017 Mar
TI  - The synergistic effect of vascular cell adhesion molecule-1 and coronary artery 
      disease on brain-derived neurotrophic factor.
PG  - 194-200
LID - S0009-8981(17)30039-6 [pii]
LID - 10.1016/j.cca.2017.01.026 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) is important for neural 
      protection and energy homeostasis. In this study, we examined the effects of 
      vascular cell adhesion molecule-1 (VCAM-1) and coronary artery disease (CAD) on 
      BDNF. METHODS: Subjects who had undergone diagnostic angiography for angina were 
      recruited, and a total of 240 subjects (144 with CAD and 96 without CAD) were 
      enrolled. Serum BDNF was determined at 0, 30, and 120min during an oral glucose 
      tolerance test (OGTT) to calculate the area under the curve (AUC) for BDNF. Serum 
      VCAM-1 was determined at fasting. RESULTS: Significantly lower AUC of BDNF 
      (42.8+/-10.7 vs. 47.4+/-11.7ng-h/ml, P=0.002) and higher serum VCAM-1 (583+/-383 vs. 
      482+/-171ng/ml, P=0.017) were noted in subjects with CAD compared to those without 
      CAD. High VCAM-1 level was an independent predictor of low AUC of BDNF in 
      subjects with and without CAD (95%CI between -0.011 and -0.002, P=0.008; -0.033 
      and -0.002, P=0.029, respectively). Serum BDNF was lowest in the CAD subjects 
      with high VCAM-1 levels at all time points during OGTT. CONCLUSION: Our results 
      showed that CAD was associated with low serum BDNF in response to OGTT, and 
      VCAM-1 had a synergistic effect with CAD on the BDNF.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Lee, I-Te
AU  - Lee IT
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Taichung Veterans General Hospital, Taichung, Taiwan; School of Medicine, Chung 
      Shan Medical University, Taichung, Taiwan; School of Medicine, National Yang-Ming 
      University, Taipei, Taiwan.
FAU - Wang, Jun-Sing
AU  - Wang JS
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Taichung Veterans General Hospital, Taichung, Taiwan; School of Medicine, 
      National Yang-Ming University, Taipei, Taiwan.
FAU - Lee, Wen-Jane
AU  - Lee WJ
AD  - Department of Medical Research, Taichung Veterans General Hospital, Taichung, 
      Taiwan.
FAU - Lin, Shih-Yi
AU  - Lin SY
AD  - School of Medicine, National Yang-Ming University, Taipei, Taiwan; Center for 
      Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung, Taiwan.
FAU - Fu, Chia-Po
AU  - Fu CP
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Taichung Veterans General Hospital, Taichung, Taiwan.
FAU - Liang, Kae-Woei
AU  - Liang KW
AD  - School of Medicine, National Yang-Ming University, Taipei, Taiwan; Cardiovascular 
      Center, Taichung Veterans General Hospital, Taichung, Taiwan.
FAU - Hsu, Chiann-Yi
AU  - Hsu CY
AD  - Department of Medical Research, Taichung Veterans General Hospital, Taichung, 
      Taiwan.
FAU - Sheu, Wayne Huey-Herng
AU  - Sheu WH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Taichung Veterans General Hospital, Taichung, Taiwan; School of Medicine, 
      National Yang-Ming University, Taipei, Taiwan; Institute of Medical Technology, 
      National Chung-Hsing University, Taichung, Taiwan. Electronic address: 
      whhsheu@vghtc.gov.tw.
LA  - eng
PT  - Journal Article
DEP - 20170125
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Angina Pectoris
MH  - Area Under Curve
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Coronary Artery Disease/*blood
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Predictive Value of Tests
MH  - Time Factors
MH  - Vascular Cell Adhesion Molecule-1/*blood
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Coronary artery disease
OT  - Oral glucose tolerance test
OT  - Vascular cell adhesion molecule-1
EDAT- 2017/01/31 06:00
MHDA- 2017/03/08 06:00
CRDT- 2017/01/30 06:00
PHST- 2016/08/03 00:00 [received]
PHST- 2017/01/21 00:00 [revised]
PHST- 2017/01/24 00:00 [accepted]
PHST- 2017/01/31 06:00 [pubmed]
PHST- 2017/03/08 06:00 [medline]
PHST- 2017/01/30 06:00 [entrez]
AID - S0009-8981(17)30039-6 [pii]
AID - 10.1016/j.cca.2017.01.026 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2017 Mar;466:194-200. doi: 10.1016/j.cca.2017.01.026. Epub 2017 
      Jan 25.