PMID- 28131907
OWN - NLM
STAT- MEDLINE
DCOM- 20180102
LR  - 20200306
IS  - 1873-5894 (Electronic)
IS  - 0730-725X (Print)
IS  - 0730-725X (Linking)
VI  - 39
DP  - 2017 Jun
TI  - 3D late gadolinium enhanced cardiovascular MR with CENTRA-PLUS profile/view 
      ordering: Feasibility of right ventricular myocardial damage assessment using a 
      swine animal model.
PG  - 7-14
LID - S0730-725X(17)30022-X [pii]
LID - 10.1016/j.mri.2017.01.015 [doi]
AB  - AIMS: To develop a high-resolution, 3D late gadolinium enhancement (LGE) 
      cardiovascular magnetic resonance imaging (MRI) technique for improved assessment 
      of myocardial scars, and evaluate its performance against 2D breath-held (BH) LGE 
      MRI using a surgically implanted animal scar model in the right ventricle (RV). 
      METHODS AND RESULTS: A k-space segmented 3D LGE acquisition using CENTRA-PLUS 
      (Contrast ENhanced Timing Robust Acquisition with Preparation of LongitUdinal 
      Signal; or CP) ordering is proposed. 8 pigs were surgically prepared with cardiac 
      patch implantation in the RV, followed in 60days by 1.5T MRI. LGE with 
      Phase-Sensitive Inversion Recovery (PSIR) were performed as follows: 1) 2DBH 
      using pneumatic control, and 2) navigator-gated, 3D free-breathing (3DFB)-CP-LGE 
      with slice-tracking. The animal heart was excised immediately after cardiac MR 
      for scar volume quantification. RV scar volumes were also delineated from the 
      2DBH and 3DFB-CP-LGE images for comparison against the surgical standard. 
      Apparent scar/normal tissue signal-to-noise ratio (aSNR) and contrast-to-noise 
      ratio (aCNR) were also calculated. 3DFB-CP-LGE technique was successfully 
      performed in all animals. No difference in aCNR was noted, but aSNR was 
      significantly higher using the 3D technique (p<0.05). Against the surgical 
      reference volume, the 3DFB-CP-LGE-derived delineation yielded significantly less 
      volume quantification error compared to 2DBH-derived volumes (15+/-10% vs 55+/-33%; 
      p<0.05). CONCLUSION: Compared to conventional 2DBH-LGE, 3DFB-LGE acquisition 
      using CENTRA-PLUS provided superior scar volume quantification and improved aSNR.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Kawaji, Keigo
AU  - Kawaji K
AD  - Department of Medicine, Section of Cardiology, The University of Chicago, 
      Chicago, IL, United States. Electronic address: 
      kkawaji@medicine.bsd.uchicago.edu.
FAU - Tanaka, Akiko
AU  - Tanaka A
AD  - Department of Radiology, The University of Chicago, Chicago, IL, United States.
FAU - Patel, Mita B
AU  - Patel MB
AD  - Department of Medicine, Section of Cardiology, The University of Chicago, 
      Chicago, IL, United States.
FAU - Wang, Hui
AU  - Wang H
AD  - Philips, Gainesville, FL, United States.
FAU - Maffessanti, Francesco
AU  - Maffessanti F
AD  - Department of Medicine, Section of Cardiology, The University of Chicago, 
      Chicago, IL, United States.
FAU - Ota, Takeyoshi
AU  - Ota T
AD  - Department of Radiology, The University of Chicago, Chicago, IL, United States.
FAU - Patel, Amit R
AU  - Patel AR
AD  - Department of Medicine, Section of Cardiology, The University of Chicago, 
      Chicago, IL, United States; Department of Surgery, Section of Cardiothoracic 
      Surgery, The University of Chicago, Chicago, IL, United States.
LA  - eng
GR  - UL1 TR000430/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20170125
PL  - Netherlands
TA  - Magn Reson Imaging
JT  - Magnetic resonance imaging
JID - 8214883
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Animals
MH  - Breath Holding
MH  - Contrast Media
MH  - Disease Models, Animal
MH  - Female
MH  - Gadolinium
MH  - Heart/*diagnostic imaging/physiopathology
MH  - Heart Ventricles/pathology
MH  - Imaging, Three-Dimensional/*methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Myocardial Infarction/pathology
MH  - Myocardium/*pathology
MH  - Respiration
MH  - Signal-To-Noise Ratio
MH  - Swine
PMC - PMC5410402
MID - NIHMS848600
OTO - NOTNLM
OT  - Breath-hold
OT  - Late gadolinium enhancement MRI
OT  - Myocardial infarction
OT  - Navigator
OT  - Viability imaging
EDAT- 2017/01/31 06:00
MHDA- 2018/01/03 06:00
PMCR- 2018/06/01
CRDT- 2017/01/30 06:00
PHST- 2016/11/01 00:00 [received]
PHST- 2016/12/27 00:00 [revised]
PHST- 2017/01/23 00:00 [accepted]
PHST- 2017/01/31 06:00 [pubmed]
PHST- 2018/01/03 06:00 [medline]
PHST- 2017/01/30 06:00 [entrez]
PHST- 2018/06/01 00:00 [pmc-release]
AID - S0730-725X(17)30022-X [pii]
AID - 10.1016/j.mri.2017.01.015 [doi]
PST - ppublish
SO  - Magn Reson Imaging. 2017 Jun;39:7-14. doi: 10.1016/j.mri.2017.01.015. Epub 2017 
      Jan 25.