PMID- 28132778
OWN - NLM
STAT- MEDLINE
DCOM- 20171127
LR  - 20171128
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 232
DP  - 2017 Apr 1
TI  - Non-permanent atrial fibrillation and oral anticoagulant therapy are related to 
      survival during 10years after first-ever ischemic stroke.
PG  - 134-139
LID - S0167-5273(17)30072-4 [pii]
LID - 10.1016/j.ijcard.2017.01.040 [doi]
AB  - BACKGROUND: Atrial fibrillation (AF) detection in ischemic stroke patients 
      triggers initiation of oral anticoagulant therapy (OAC). However, little is known 
      regarding whether the persistency of AF affects long-term prognosis after 
      ischemic stroke. We aimed to assess the impact of AF types and OAC on the outcome 
      during a 10-year follow-up (FU) after first-ever ischemic stroke. MATERIAL AND 
      METHODS: The study sample comprised 336 first-ever ischemic stroke patients 
      (median age 76, interquartile range 25-75% (IQR) 67-82years, 136 female) included 
      in the Lund Stroke Register (LSR) in 2001-2002. At baseline, 109 patients had 
      either permanent (n=44) or recurrent (n=65) AF. OAC was assessed using the Lund 
      University Hospital anticoagulation database. All-cause mortality was assessed 
      via linkage with the Swedish Causes of Death Register. RESULTS: During FU, 200 
      patients died. AF independently predicted all-cause mortality (hazard ratio (HR) 
      1.52 95% CI 1.14-2.04, p=0.005); the worst prognosis was observed for permanent 
      AF (HR 1.86 95% CI 1.29-2.69, p=0.001). Patients with recurrent AF receiving OAC 
      had similar survival rates to patients without AF (HR 0.73 95% CI 0.38-1.39, 
      p=0.333), while prognosis was worst for patients with permanent AF without OAC 
      (HR 2.28 95% CI 1.38-3.77, p=0.001) and intermediate for patients with permanent 
      AF on OAC (HR 1.57 95% CI 0.92-2.67, p=0.099). CONCLUSION: All-cause mortality 
      was independently associated with AF and was the greatest in stroke patients with 
      permanent AF. Patients with recurrent AF receiving OAC have the most favorable 
      outcome, similar to those without AF and significantly better than OAC-treated 
      patients with permanent AF.
CI  - Copyright A(c) 2017 Elsevier Ireland Ltd. All rights reserved.
FAU - Baturova, Maria A
AU  - Baturova MA
AD  - Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden; St. 
      Petersburg University Clinic, St. Petersburg, Russia; Cardiology Research, 
      Clinical and Educational Center, St. Petersburg State University, St. Petersburg, 
      Russia. Electronic address: Maria.Baturova@med.lu.se.
FAU - Lindgren, Arne
AU  - Lindgren A
AD  - Department of Neurology and Rehabilitation Medicine, Skane University Hospital, 
      Lund, Sweden; Department of Clinical Sciences Lund, Neurology, Lund University, 
      Sweden.
FAU - Carlson, Jonas
AU  - Carlson J
AD  - Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden.
FAU - Shubik, Yuri V
AU  - Shubik YV
AD  - Cardiology Research, Clinical and Educational Center, St. Petersburg State 
      University, St. Petersburg; St. Petersburg University Clinic, St. Petersburg, 
      Russia.
FAU - Bertil Olsson, S
AU  - Bertil Olsson S
AD  - Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden.
FAU - Platonov, Pyotr G
AU  - Platonov PG
AD  - Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden; 
      Arrythmia Clinic, Skane University Hospital, Lund, Sweden.
LA  - eng
PT  - Journal Article
DEP - 20170105
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Anticoagulants)
SB  - IM
MH  - Administration, Oral
MH  - Aged
MH  - Aged, 80 and over
MH  - Anticoagulants/*administration & dosage
MH  - Atrial Fibrillation/complications/drug therapy/*mortality
MH  - Brain Ischemia/etiology/mortality/*prevention & control
MH  - Cause of Death/trends
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Follow-Up Studies
MH  - *Forecasting
MH  - Humans
MH  - Male
MH  - Prognosis
MH  - *Registries
MH  - Retrospective Studies
MH  - *Risk Assessment
MH  - Risk Factors
MH  - Survival Rate/trends
MH  - Sweden/epidemiology
OTO - NOTNLM
OT  - All-cause mortality
OT  - Atrial fibrillation
OT  - Ischemic stroke
OT  - Oral anticoagulant therapy
OT  - Permanent AF
OT  - Recurrent AF
EDAT- 2017/01/31 06:00
MHDA- 2017/11/29 06:00
CRDT- 2017/01/31 06:00
PHST- 2016/08/10 00:00 [received]
PHST- 2016/12/05 00:00 [revised]
PHST- 2017/01/04 00:00 [accepted]
PHST- 2017/01/31 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2017/01/31 06:00 [entrez]
AID - S0167-5273(17)30072-4 [pii]
AID - 10.1016/j.ijcard.2017.01.040 [doi]
PST - ppublish
SO  - Int J Cardiol. 2017 Apr 1;232:134-139. doi: 10.1016/j.ijcard.2017.01.040. Epub 
      2017 Jan 5.