PMID- 28133267
OWN - NLM
STAT- MEDLINE
DCOM- 20170908
LR  - 20170908
IS  - 0385-0684 (Print)
IS  - 0385-0684 (Linking)
VI  - 43
IP  - 12
DP  - 2016 Nov
TI  - [Multiple Endocrine Neoplasia Type 1(MEN1)Presenting with Hypoglycemic Attacks - 
      A Case Report].
PG  - 2196-2198
AB  - A woman in her 60s visited our hospital because of frequent hypoglycemia and 
      episodes of unconsciousness over the last 6 years. A 4 cm tumor was detected on 
      the pancreatic tail using abdominal computed tomography and ultrasonography. An 
      insulinoma was strongly suspected from the results of the fasting test and 
      glucagon load test, and a distal pancreatectomy with splenectomy was performed. 
      Pathological examination indicated an insulinoma and neuroendocrine tumor(NET)G2 
      based on the WHO 2010 classification. The patient's blood sugar and insulin 
      levels returned to normal, and hypoglycemic attacks disappeared postoperatively. 
      Six months later, a total parathyroidectomy was performed because of primary 
      hyperparathyroidism with hypertrophy of the parathyroid glands. Furthermore, 
      pituitary swellingwas also detected usinghead MRI. However, the patient has been 
      under observation because the tumor was non-functional without any associated 
      symptoms. Thus, we diagnosed the patient with multiple endocrine neoplasia type 
      1(MEN1). In patients with pancreatic NET, it is necessary to consider the 
      possibility of MEN1.
FAU - Okubo, Yusuke
AU  - Okubo Y
AD  - Dept. of Surgery, Kobe Ekisaikai Hospital.
FAU - Tono, Takeshi
AU  - Tono T
FAU - Fukamizu, Maki
AU  - Fukamizu M
FAU - Kawasaki, Yasuhito
AU  - Kawasaki Y
FAU - Shinozaki, Koji
AU  - Shinozaki K
FAU - Ishii, Takaaki
AU  - Ishii T
FAU - Katayama, Tomohiro
AU  - Katayama T
FAU - Yamauchi, Yumiko
AU  - Yamauchi Y
FAU - Fukamizu, Hideaki
AU  - Fukamizu H
FAU - Tominaga, Takashi
AU  - Tominaga T
FAU - Senba, Shuho
AU  - Senba S
FAU - Yasuda, Seiji
AU  - Yasuda S
FAU - Otsuru, Minoru
AU  - Otsuru M
LA  - jpn
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Gan To Kagaku Ryoho
JT  - Gan to kagaku ryoho. Cancer & chemotherapy
JID - 7810034
SB  - IM
MH  - Female
MH  - Humans
MH  - Hypoglycemia/*etiology
MH  - *Multiple Endocrine Neoplasia Type 1/complications/diagnostic imaging/surgery
MH  - Pancreatectomy
MH  - Pancreatic Neoplasms/complications/diagnostic imaging/*pathology/surgery
MH  - Prognosis
MH  - Tomography, X-Ray Computed
EDAT- 2017/01/31 06:00
MHDA- 2017/09/09 06:00
CRDT- 2017/01/31 06:00
PHST- 2017/01/31 06:00 [entrez]
PHST- 2017/01/31 06:00 [pubmed]
PHST- 2017/09/09 06:00 [medline]
PST - ppublish
SO  - Gan To Kagaku Ryoho. 2016 Nov;43(12):2196-2198.