PMID- 28133445
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1662-5099 (Print)
IS  - 1662-5099 (Electronic)
IS  - 1662-5099 (Linking)
VI  - 9
DP  - 2016
TI  - ON or OFF?: Modulating the N-Methyl-D-Aspartate Receptor in Major Depression.
PG  - 169
LID - 10.3389/fnmol.2016.00169 [doi]
LID - 169
AB  - Since the discovery that a single dose of ketamine, an N-methyl-D-aspartate 
      receptor (NMDAR) antagonist, had rapid and long-lasting antidepressant effects, 
      there has been increased interest in using NMDAR modulators in the 
      pharmacotherapy of depression. Ketamine's efficacy seems to imply that depression 
      is a disorder of NMDAR hyperfunctionality. However, studies showing that not all 
      NMDAR antagonists are able to act as antidepressants challenge this notion. 
      Furthermore, NMDAR co-agonists have also been gaining attention as possible 
      treatments. Co-agonists such as D-serine and sarcosine have shown efficacy in 
      both pre-clinical models and human trials. This raises the question of how both 
      NMDAR antagonists and agonists are able to have converging behavioral effects. 
      Here we critically review the evidence and proposed therapeutic mechanisms for 
      both NMDAR antagonists and agonists, and collate several theories on how both 
      activation and inhibition of NMDARs appear to have antidepressant effects.
FAU - Chan, Shi Yu
AU  - Chan SY
AD  - Department of Psychiatry, Warneford Hospital, University of Oxford Oxford, UK.
FAU - Matthews, Edward
AU  - Matthews E
AD  - Green Templeton College, University of Oxford Oxford, UK.
FAU - Burnet, Philip W J
AU  - Burnet PW
AD  - Department of Psychiatry, Warneford Hospital, University of Oxford Oxford, UK.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170113
PL  - Switzerland
TA  - Front Mol Neurosci
JT  - Frontiers in molecular neuroscience
JID - 101477914
PMC - PMC5233677
OTO - NOTNLM
OT  - NMDAR antagonist
OT  - depression
OT  - glycine site
OT  - mTOR
OT  - subunit
EDAT- 2017/01/31 06:00
MHDA- 2017/01/31 06:01
PMCR- 2016/01/01
CRDT- 2017/01/31 06:00
PHST- 2016/11/04 00:00 [received]
PHST- 2016/12/27 00:00 [accepted]
PHST- 2017/01/31 06:00 [entrez]
PHST- 2017/01/31 06:00 [pubmed]
PHST- 2017/01/31 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.3389/fnmol.2016.00169 [doi]
PST - epublish
SO  - Front Mol Neurosci. 2017 Jan 13;9:169. doi: 10.3389/fnmol.2016.00169. eCollection 
      2016.