PMID- 28133479 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240324 IS - 1687-6121 (Print) IS - 1687-630X (Electronic) IS - 1687-6121 (Linking) VI - 2017 DP - 2017 TI - Metformin and Diammonium Glycyrrhizinate Enteric-Coated Capsule versus Metformin Alone versus Diammonium Glycyrrhizinate Enteric-Coated Capsule Alone in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus. PG - 8491742 LID - 10.1155/2017/8491742 [doi] LID - 8491742 AB - Objective. The present study was conducted to compare the efficacy of metformin combined with diammonium glycyrrhizinate enteric-coated capsule (DGEC) versus metformin alone versus DGEC alone for the treatment of nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). Subjects and Methods. 163 patients with NAFLD and T2DM were enrolled in this 24-week study and were randomized to one of three groups: group 1 was treated with metformin alone; group 2 was treated with DGEC alone; group 3 received metformin plus DGEC combination therapy. Anthropometric parameters, liver function, lipid profile, serum ferritin (SF), metabolic parameters, liver/spleen computed tomography (CT) ratio, and fibroscan value were evaluated at baseline and after 8, 16, and 24 weeks of treatment. Results. After 24 weeks, significant improvements in all measured parameters were observed in three groups (P < 0.05) except for the improvements in low density lipoprotein cholesterol (LDL-C) and metabolic parameters in group 2 which did not reach statistical significance (P > 0.05). Compared with group 1 and group 2, the patients in group 3 had greater reductions in observed parameters apart from CB and TB (P < 0.05). Conclusions. This study showed that metformin plus DGEC was more effective than metformin alone or DGEC alone in reducing liver enzymes, lipid levels, and metabolic parameters and ameliorating the degree of hepatic fibrosis in patients with NAFLD and T2DM. FAU - Zhang, Rong AU - Zhang R AD - Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China; The First Clinical Medical College of Nanjing Medical University, Nanjing 210029, China. FAU - Cheng, Keran AU - Cheng K AD - Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China; The School of Medicine of Soochow University, Suzhou 215006, China. FAU - Xu, Shizan AU - Xu S AD - Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China; The First Clinical Medical College of Nanjing Medical University, Nanjing 210029, China. FAU - Li, Sainan AU - Li S AD - Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China. FAU - Zhou, Yuqing AU - Zhou Y AD - Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China; The School of Medicine of Soochow University, Suzhou 215006, China. FAU - Zhou, Shunfeng AU - Zhou S AD - Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China; The School of Medicine of Soochow University, Suzhou 215006, China. FAU - Kong, Rui AU - Kong R AD - Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China; The School of Medicine of Soochow University, Suzhou 215006, China. FAU - Li, Linqiang AU - Li L AD - Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China; The School of Medicine of Soochow University, Suzhou 215006, China. FAU - Li, Jingjing AU - Li J AD - Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China. FAU - Feng, Jiao AU - Feng J AD - Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China. FAU - Wu, Liwei AU - Wu L AD - Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China. FAU - Liu, Tong AU - Liu T AD - Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China. FAU - Xia, Yujing AU - Xia Y AD - Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China. FAU - Lu, Jie AU - Lu J AUID- ORCID: 0000-0002-1814-2125 AD - Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China. FAU - Guo, Chuanyong AU - Guo C AUID- ORCID: 0000-0002-5658-600X AD - Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China. FAU - Zhou, Yingqun AU - Zhou Y AUID- ORCID: 0000-0001-8757-9657 AD - Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China. LA - eng PT - Journal Article DEP - 20170104 PL - Egypt TA - Gastroenterol Res Pract JT - Gastroenterology research and practice JID - 101475557 PMC - PMC5241454 COIS- The authors declare that they have no competing interests. EDAT- 2017/01/31 06:00 MHDA- 2017/01/31 06:01 PMCR- 2017/01/04 CRDT- 2017/01/31 06:00 PHST- 2016/09/14 00:00 [received] PHST- 2016/11/24 00:00 [accepted] PHST- 2017/01/31 06:00 [entrez] PHST- 2017/01/31 06:00 [pubmed] PHST- 2017/01/31 06:01 [medline] PHST- 2017/01/04 00:00 [pmc-release] AID - 10.1155/2017/8491742 [doi] PST - ppublish SO - Gastroenterol Res Pract. 2017;2017:8491742. doi: 10.1155/2017/8491742. Epub 2017 Jan 4.