PMID- 28133614
OWN - NLM
STAT- MEDLINE
DCOM- 20170217
LR  - 20240324
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2017
DP  - 2017
TI  - Idiosyncratic Drug-Induced Liver Injury (IDILI): Potential Mechanisms and 
      Predictive Assays.
PG  - 9176937
LID - 10.1155/2017/9176937 [doi]
LID - 9176937
AB  - Idiosyncratic drug-induced liver injury (IDILI) is a significant source of drug 
      recall and acute liver failure (ALF) in the United States. While current drug 
      development processes emphasize general toxicity and drug metabolizing enzyme- 
      (DME-) mediated toxicity, it has been challenging to develop comprehensive models 
      for assessing complete idiosyncratic potential. In this review, we describe the 
      enzymes and proteins that contain polymorphisms believed to contribute to IDILI, 
      including ones that affect phase I and phase II metabolism, antioxidant enzymes, 
      drug transporters, inflammation, and human leukocyte antigen (HLA). We then 
      describe the various assays that have been developed to detect individual 
      reactions focusing on each of the mechanisms described in the background. 
      Finally, we examine current trends in developing comprehensive models for 
      examining these mechanisms. There is an urgent need to develop a panel of 
      multiparametric assays for diagnosing individual toxicity potential.
FAU - Roth, Alexander D
AU  - Roth AD
AD  - Department of Chemical & Biomedical Engineering, Cleveland State University, 1960 
      East 24th Street, Cleveland, OH 44115-2214, USA.
FAU - Lee, Moo-Yeal
AU  - Lee MY
AUID- ORCID: 0000-0001-6922-609X
AD  - Department of Chemical & Biomedical Engineering, Cleveland State University, 1960 
      East 24th Street, Cleveland, OH 44115-2214, USA.
LA  - eng
GR  - R01 ES025779/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20170104
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
SB  - IM
MH  - Biological Assay/*methods
MH  - Chemical and Drug Induced Liver Injury/*diagnosis/genetics
MH  - Coculture Techniques
MH  - Humans
MH  - Inflammation/metabolism/pathology
MH  - Metabolic Detoxication, Phase II
MH  - Signal Transduction
PMC - PMC5241492
COIS- The authors declare that there are no competing interests regarding the 
      publication of this paper.
EDAT- 2017/01/31 06:00
MHDA- 2017/02/18 06:00
PMCR- 2017/01/04
CRDT- 2017/01/31 06:00
PHST- 2016/10/07 00:00 [received]
PHST- 2016/11/29 00:00 [accepted]
PHST- 2017/01/31 06:00 [entrez]
PHST- 2017/01/31 06:00 [pubmed]
PHST- 2017/02/18 06:00 [medline]
PHST- 2017/01/04 00:00 [pmc-release]
AID - 10.1155/2017/9176937 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:9176937. doi: 10.1155/2017/9176937. Epub 2017 Jan 4.