PMID- 28135401
OWN - NLM
STAT- MEDLINE
DCOM- 20170502
LR  - 20181202
IS  - 1750-3841 (Electronic)
IS  - 0022-1147 (Linking)
VI  - 82
IP  - 2
DP  - 2017 Feb
TI  - Effects of Different Simple Triglycerides on Cell Fatty Acid Compositions, 
      Proliferation-Related Protein, and Gene Expressions Induced by Oxidized-LDL in 
      HUVSMCs.
PG  - 529-535
LID - 10.1111/1750-3841.13621 [doi]
AB  - The proliferating effects of 3 different simple triglycerides (tristearin, 
      triolein, and trilinolein) on the human umbilical vein smooth muscle cells 
      (HUVSMCs) induced by oxidized-LDL (ox-LDL) were investigated in this study. The 
      protein and mRNA gene expressions of proliferating cell nuclear antigen (PCNA), 
      smooth muscle-alpha-actin (SM-alpha-actin), and monocyte chemoattractant protein-1 
      (MCP-1) in HUVSMCs were measured by Western blotting and real-time quantitative 
      polymerase chain reaction (PCR). It was shown that in tristearin (SSS) treated 
      HUVSMCs, the saturated fatty acid content was increased, and the compositions of 
      polyunsaturated fatty acid (PUFA) and monounsaturated fatty acid were decreased 
      significantly. On the other hand, triolein (OOO) and trilinolein (LLL) 
      significantly increased the levels of some typical PUFA such as arachidonic acid, 
      eicosapentaenoic acid, and docosahexaenoic acid. Moreover, LLL and OOO could 
      upregulate the protein and mRNA expressions of PCNA, MCP-1 as well as 
      downregulate the expression of SM-alpha-actin. The results also showed that, SSS had 
      significant promotion effects on the proliferation of HUVSMCs induced by ox-LDL. 
      Although both LLL and OOO could inhibit the proliferation of HUVSMCs induced by 
      ox-LDL, and might have certain inhibition of the atherosclerotic process.
CI  - (c) 2017 Institute of Food Technologists(R).
FAU - Li, Hongyan
AU  - Li H
AD  - State Key Laboratory of Food Science and Technology, Univ. of Nanchang, Nanchang, 
      330047, Jiangxi, China.
FAU - Pan, Yao
AU  - Pan Y
AD  - State Key Laboratory of Food Science and Technology, Univ. of Nanchang, Nanchang, 
      330047, Jiangxi, China.
FAU - Luo, Kaiyun
AU  - Luo K
AD  - State Key Laboratory of Food Science and Technology, Univ. of Nanchang, Nanchang, 
      330047, Jiangxi, China.
FAU - Luo, Ting
AU  - Luo T
AD  - State Key Laboratory of Food Science and Technology, Univ. of Nanchang, Nanchang, 
      330047, Jiangxi, China.
FAU - Fan, Yawei
AU  - Fan Y
AD  - State Key Laboratory of Food Science and Technology, Univ. of Nanchang, Nanchang, 
      330047, Jiangxi, China.
FAU - Deng, Zeyuan
AU  - Deng Z
AD  - State Key Laboratory of Food Science and Technology, Univ. of Nanchang, Nanchang, 
      330047, Jiangxi, China.
AD  - Inst. for Advanced Study, Univ. of Nanchang, Nanchang, 330031, Jiangxi, China.
LA  - eng
PT  - Journal Article
DEP - 20170130
PL  - United States
TA  - J Food Sci
JT  - Journal of food science
JID - 0014052
RN  - 0 (Actins)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Proliferating Cell Nuclear Antigen)
RN  - 0 (Triglycerides)
RN  - 0 (oxidized low density lipoprotein)
RN  - 122-32-7 (Triolein)
RN  - P6OCJ2551R (tristearin)
RN  - V5LJ52OGS7 (trilinolein)
SB  - IM
MH  - Actins/metabolism
MH  - Atherosclerosis/metabolism
MH  - Cells, Cultured
MH  - Chemokine CCL2/metabolism
MH  - Fatty Acids, Unsaturated/chemistry
MH  - Gene Expression/drug effects
MH  - Gene Expression Regulation
MH  - Humans
MH  - Lipoproteins, LDL/*metabolism
MH  - Muscle, Smooth, Vascular/cytology
MH  - Myocytes, Smooth Muscle/*metabolism
MH  - Proliferating Cell Nuclear Antigen/*metabolism
MH  - Triglycerides/*chemistry
MH  - Triolein/chemistry
OTO - NOTNLM
OT  - HUVSMC
OT  - ox-LDL
OT  - trilinolein
OT  - triolein
OT  - tristearin
EDAT- 2017/01/31 06:00
MHDA- 2017/05/04 06:00
CRDT- 2017/01/31 06:00
PHST- 2016/05/28 00:00 [received]
PHST- 2016/11/23 00:00 [revised]
PHST- 2016/12/13 00:00 [accepted]
PHST- 2017/01/31 06:00 [pubmed]
PHST- 2017/05/04 06:00 [medline]
PHST- 2017/01/31 06:00 [entrez]
AID - 10.1111/1750-3841.13621 [doi]
PST - ppublish
SO  - J Food Sci. 2017 Feb;82(2):529-535. doi: 10.1111/1750-3841.13621. Epub 2017 Jan 
      30.