PMID- 28137497
OWN - NLM
STAT- MEDLINE
DCOM- 20180108
LR  - 20220321
IS  - 1532-3064 (Electronic)
IS  - 0954-6111 (Linking)
VI  - 123
DP  - 2017 Feb
TI  - Interstitial pneumonia with autoimmune features: Clinical, radiologic, and 
      histological characteristics and outcome in a series of 57 patients.
PG  - 56-62
LID - S0954-6111(16)30280-3 [pii]
LID - 10.1016/j.rmed.2016.10.017 [doi]
AB  - BACKGROUND: Interstitial pneumonia with autoimmune features (IPAF) has recently 
      been defined by an international Taskforce to characterize interstitial lung 
      disease associated with systemic manifestations limited to subtle serological and 
      clinical autoimmune abnormalities and not fulfilling the international criteria 
      for the diagnosis of a given connective tissue disease. OBJECTIVE: to report on a 
      series of patients with IPAF, and to compare their outcome to that of a cohort of 
      patients with idiopathic pulmonary fibrosis (IPF). METHODS: Retrospective 
      analysis of consecutive patients in a single institution over a 3-year period. 
      RESULTS: Out of 778 consecutive patients with interstitial lung disease, 55% had 
      idiopathic interstitial pneumonia (including 20.1% with IPF), 21.5% had 
      connective tissue disease, and 7.3% had IPAF. Patients (49% of females) had a 
      mean FVC of 64% and a mean DLco of 49%. Serologic criteria for IPAF were the most 
      frequent (93%), followed by "morphologic" criteria (79%), and clinical criteria 
      (47%). Fifty three percent of patients had a NSIP pattern on CT. Nailfold 
      capillaroscopy found giant capillaries in 13/30 patients tested (23%). No 
      significant was found in overall survival between patients with IPAF and those 
      with IPF. CONCLUSION: The recently defined criteria for IPAF are fulfilled by a 
      significant proportion of patients referred for interstitial lung disease. As 
      compared to those with IPF, patients with IPAF are more frequently females, have 
      distinctive characteristics, have relatively frequent abnormalities at nailfold 
      capillaroscopy, with no difference in age or in overall survival. Prospective 
      studies are needed to guide the management of IPAF.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Ahmad, Kais
AU  - Ahmad K
AD  - Hospices Civils de Lyon, Groupe Hospitalier Est, Service de Pneumologie - Centre 
      national de Reference des Maladies Pulmonaires Rares, Universite de Lyon, 
      Universite Lyon I, UCBL-INRA, UMR754, Lyon, France.
FAU - Barba, Thomas
AU  - Barba T
AD  - Hospices Civils de Lyon, Groupe Hospitalier Est, Service de Pneumologie - Centre 
      national de Reference des Maladies Pulmonaires Rares, Universite de Lyon, 
      Universite Lyon I, UCBL-INRA, UMR754, Lyon, France.
FAU - Gamondes, Delphine
AU  - Gamondes D
AD  - Hospices Civils de Lyon, Groupe Hospitalier Est, Service de Radiologie, Lyon, 
      France.
FAU - Ginoux, Marylise
AU  - Ginoux M
AD  - Hospices Civils de Lyon, Groupe Hospitalier Est, Service de Pneumologie - Centre 
      national de Reference des Maladies Pulmonaires Rares, Universite de Lyon, 
      Universite Lyon I, UCBL-INRA, UMR754, Lyon, France.
FAU - Khouatra, Chahera
AU  - Khouatra C
AD  - Hospices Civils de Lyon, Groupe Hospitalier Est, Service de Pneumologie - Centre 
      national de Reference des Maladies Pulmonaires Rares, Universite de Lyon, 
      Universite Lyon I, UCBL-INRA, UMR754, Lyon, France.
FAU - Spagnolo, Paolo
AU  - Spagnolo P
AD  - Section of Respiratory Diseases, Department of Cardiac, Thoracic and Vascular 
      Sciences, University of Padua, Padua, Italy.
FAU - Strek, Mary
AU  - Strek M
AD  - Section of Pulmonary and Critical Care Medicine, Department of Medicine, 
      University of Chicago, Chicago, IL, USA.
FAU - Thivolet-Bejui, Francoise
AU  - Thivolet-Bejui F
AD  - Hospices Civils de Lyon, Groupe Hospitalier Est, Centre de Pathologie Est, 
      Universite de Lyon, Universite Lyon I, Lyon, France.
FAU - Traclet, Julie
AU  - Traclet J
AD  - Hospices Civils de Lyon, Groupe Hospitalier Est, Service de Pneumologie - Centre 
      national de Reference des Maladies Pulmonaires Rares, Universite de Lyon, 
      Universite Lyon I, UCBL-INRA, UMR754, Lyon, France.
FAU - Cottin, Vincent
AU  - Cottin V
AD  - Hospices Civils de Lyon, Groupe Hospitalier Est, Service de Pneumologie - Centre 
      national de Reference des Maladies Pulmonaires Rares, Universite de Lyon, 
      Universite Lyon I, UCBL-INRA, UMR754, Lyon, France. Electronic address: 
      vincent.cottin@chu-lyon.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161031
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
SB  - IM
CIN - Respir Med. 2017 Jun;127:65-66. PMID: 28285991
CIN - Respir Med. 2017 Jun;127:67. PMID: 28416271
MH  - Aged
MH  - Autoimmune Diseases/*diagnosis/pathology
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Idiopathic Pulmonary Fibrosis/diagnosis
MH  - Kaplan-Meier Estimate
MH  - Lung Diseases, Interstitial/*diagnosis/pathology
MH  - Male
MH  - Microscopic Angioscopy
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - Connected tissue disease
OT  - Idiopathic pulmonary fibrosis
OT  - Interstitial lung disease
OT  - Interstitial pneumonia
EDAT- 2017/02/01 06:00
MHDA- 2018/01/09 06:00
CRDT- 2017/02/01 06:00
PHST- 2016/06/22 00:00 [received]
PHST- 2016/09/23 00:00 [revised]
PHST- 2016/10/24 00:00 [accepted]
PHST- 2017/02/01 06:00 [entrez]
PHST- 2017/02/01 06:00 [pubmed]
PHST- 2018/01/09 06:00 [medline]
AID - S0954-6111(16)30280-3 [pii]
AID - 10.1016/j.rmed.2016.10.017 [doi]
PST - ppublish
SO  - Respir Med. 2017 Feb;123:56-62. doi: 10.1016/j.rmed.2016.10.017. Epub 2016 Oct 
      31.