PMID- 28138732
OWN - NLM
STAT- MEDLINE
DCOM- 20180202
LR  - 20181202
IS  - 1432-2323 (Electronic)
IS  - 0364-2313 (Linking)
VI  - 41
IP  - 6
DP  - 2017 Jun
TI  - Limited Value of Ga-68-DOTATOC-PET-CT in Routine Screening of Patients with 
      Multiple Endocrine Neoplasia Type 1.
PG  - 1521-1527
LID - 10.1007/s00268-017-3907-9 [doi]
AB  - BACKGROUND: Routine screening is recommended for patients with multiple endocrine 
      neoplasia type 1 (MEN1) to enable early detection and treatment of associated 
      neuroendocrine neoplasms (NEN). Gallium(68)-DOTATOC-Positron emission tomography 
      combined with computed tomography (Ga-68-DOTATOC-PET-CT) is a very sensitive and 
      specific imaging technique for the detection of sporadic neuroendocrine tumors. 
      The present study evaluated the value of Ga-68-DOTATOC-PET-CT in routine 
      screening of patients with MEN1. METHODS: Between January 2014 and March 2016, 
      all MEN1 patients underwent Ga-68-DOTATOC-PET-CT in addition to conventional 
      imaging (computed tomography of the thorax, magnetic resonance imaging of the 
      abdomen and pituitary, endoscopic ultrasonography). The diagnostic yield of 
      conventional imaging and Ga-68-DOTATOC-PET-CT was prospectively documented and 
      compared, and treatment changes caused by the addition of Ga-68-DOTATOC-PET-CT 
      were recorded. RESULTS: Conventional imaging detected 145 NENs, mainly 
      pancreaticoduodenal NENs (n = 117, 81%), in 31 of 33 MEN1 patients. 
      Ga-68-DOTATOC-PET-CT detected 55 NENs in 23 of the 33 patients (p = 0.0001). 
      Ninety (62%) NENs detected by conventional imaging were missed by DOTATOC-PET-CT. 
      The majority of missed lesions were pNEN (n = 68; 74%). The sensitivity of 
      Ga-68-DOTATOC-PET-CT for NENs <5, 5-9, 10-19 and >/=20 mm was 0, 29, 81 and 100%, 
      respectively. However, Ga-68-DOTATOC-PET-CT detected more liver and lymph node 
      metastases in patients with known metastatic disease, which did not lead to a 
      change of patients' management. In one patient (3%), Ga-68-DOTATOC-PET-CT was the 
      only imaging modality that detected a small intestine NEN and led to potentially 
      curative surgery. CONCLUSION: Ga-68-DOTATOC-PET-CT cannot be recommended for 
      routine screening of MEN1 patients. It might provide important additional 
      information in patients with suspected or known metastatic disease.
FAU - Albers, Max B
AU  - Albers MB
AD  - Department of Visceral, Thoracic and Vascular Surgery, University Hospital of 
      Giessen and Marburg, Philipps University of Marburg, Marburg, Germany. 
      max.b.albers@gmail.com.
FAU - Librizzi, Damiano
AU  - Librizzi D
AD  - Department of Nuclear Medicine, University Hospital of Giessen and Marburg, 
      Philipps University of Marburg, Marburg, Germany.
FAU - Lopez, Caroline L
AU  - Lopez CL
AD  - Department of Visceral, Thoracic and Vascular Surgery, University Hospital of 
      Giessen and Marburg, Philipps University of Marburg, Marburg, Germany.
FAU - Manoharan, Jerena
AU  - Manoharan J
AD  - Department of Visceral, Thoracic and Vascular Surgery, University Hospital of 
      Giessen and Marburg, Philipps University of Marburg, Marburg, Germany.
FAU - Apitzsch, Jonas C
AU  - Apitzsch JC
AD  - Department of Diagnostic and Interventional Radiology, University Hospital of 
      Giessen and Marburg, Philipps University of Marburg, Marburg, Germany.
FAU - Slater, Emily P
AU  - Slater EP
AD  - Department of Visceral, Thoracic and Vascular Surgery, University Hospital of 
      Giessen and Marburg, Philipps University of Marburg, Marburg, Germany.
FAU - Bollmann, Carmen
AU  - Bollmann C
AD  - Department of Visceral, Thoracic and Vascular Surgery, University Hospital of 
      Giessen and Marburg, Philipps University of Marburg, Marburg, Germany.
FAU - Kann, Peter H
AU  - Kann PH
AD  - Division of Endocrinology, University Hospital of Giessen and Marburg, Philipps 
      University of Marburg, Marburg, Germany.
FAU - Bartsch, Detlef K
AU  - Bartsch DK
AD  - Department of Visceral, Thoracic and Vascular Surgery, University Hospital of 
      Giessen and Marburg, Philipps University of Marburg, Marburg, Germany.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Surg
JT  - World journal of surgery
JID - 7704052
RN  - 0 (Radiopharmaceuticals)
RN  - RWM8CCW8GP (Octreotide)
RN  - U194AS08HZ (Edotreotide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*diagnostic imaging
MH  - Octreotide/*analogs & derivatives
MH  - Positron Emission Tomography Computed Tomography/*methods
MH  - *Radiopharmaceuticals
EDAT- 2017/02/01 06:00
MHDA- 2018/02/03 06:00
CRDT- 2017/02/01 06:00
PHST- 2017/02/01 06:00 [pubmed]
PHST- 2018/02/03 06:00 [medline]
PHST- 2017/02/01 06:00 [entrez]
AID - 10.1007/s00268-017-3907-9 [pii]
AID - 10.1007/s00268-017-3907-9 [doi]
PST - ppublish
SO  - World J Surg. 2017 Jun;41(6):1521-1527. doi: 10.1007/s00268-017-3907-9.