PMID- 28138831
OWN - NLM
STAT- MEDLINE
DCOM- 20171020
LR  - 20220409
IS  - 1573-3432 (Electronic)
IS  - 0162-3257 (Linking)
VI  - 47
IP  - 4
DP  - 2017 Apr
TI  - Brain-Derived Neurotrophic Factor Levels in Autism: A Systematic Review and 
      Meta-Analysis.
PG  - 1018-1029
LID - 10.1007/s10803-016-3024-x [doi]
AB  - Brain-derived neurotrophic factor (BDNF) plays an important role in 
      activity-dependent synaptic plasticity. Altered blood BDNF levels have been 
      frequently identified in people with autism spectrum disorders (ASD). There are 
      however wide discrepancies in the evidence. Therefore, we performed the present 
      systematic review and meta-analysis aimed at qualitative and quantitative 
      synthesis of studies that measured blood BDNF levels in ASD and control subjects. 
      Observational studies were identified through electronic database searching and 
      also hand-searching of reference lists of relevant articles. A total of 183 
      papers were initially identified for review and eventually twenty studies were 
      included in the meta-analysis. A meta-analysis of blood BDNF in 887 patients with 
      ASD and 901 control subjects demonstrated significantly higher BDNF levels in ASD 
      compared to controls with the SMD of 0.47 (95% CI 0.07-0.86, p = 0.02). In 
      addition subgroup meta-analyses were performed based on the BDNF specimen. The 
      present meta-analysis study led to conclusion that BDNF might play role in autism 
      initiation/ propagation and therefore it can be considered as a possible 
      biomarker of ASD.
FAU - Saghazadeh, Amene
AU  - Saghazadeh A
AD  - Research Center for Immunodeficiencies, Children's Medical Center, Tehran 
      University of Medical Sciences, Tehran, Iran.
AD  - MetaCognition Interest Group (MCIG), Universal Scientific Education and Research 
      Network (USERN), Tehran, Iran.
FAU - Rezaei, Nima
AU  - Rezaei N
AD  - Research Center for Immunodeficiencies, Children's Medical Center, Tehran 
      University of Medical Sciences, Tehran, Iran. rezaei_nima@tums.ac.ir.
AD  - Department of Immunology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran. rezaei_nima@tums.ac.ir.
AD  - Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific 
      Education and Research Network (USERN), Boston, MA, USA. rezaei_nima@tums.ac.ir.
AD  - Children's Medical Center Hospital, Dr. Qarib St, Keshavarz Blvd, Tehran, 14194, 
      Iran. rezaei_nima@tums.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - J Autism Dev Disord
JT  - Journal of autism and developmental disorders
JID - 7904301
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Autism Spectrum Disorder/*blood
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Female
MH  - Humans
MH  - Male
OTO - NOTNLM
OT  - *Autism
OT  - *Brain-derived neurotrophic factor
OT  - *Meta-analysis
OT  - *Neuroplasticity
OT  - *Systematic review
EDAT- 2017/02/01 06:00
MHDA- 2017/10/21 06:00
CRDT- 2017/02/01 06:00
PHST- 2017/02/01 06:00 [pubmed]
PHST- 2017/10/21 06:00 [medline]
PHST- 2017/02/01 06:00 [entrez]
AID - 10.1007/s10803-016-3024-x [pii]
AID - 10.1007/s10803-016-3024-x [doi]
PST - ppublish
SO  - J Autism Dev Disord. 2017 Apr;47(4):1018-1029. doi: 10.1007/s10803-016-3024-x.