PMID- 28139163
OWN - NLM
STAT- MEDLINE
DCOM- 20180117
LR  - 20180430
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Linking)
VI  - 42
IP  - 6
DP  - 2017 Jun
TI  - Comparison of Autologous Serum Versus Preservative Free Artificial Tear in 
      Patients with Dry Eyes Due to Systemic Isotretinoin Therapy.
PG  - 827-831
LID - 10.1080/02713683.2016.1255758 [doi]
AB  - PURPOSE: To investigate dry eye development in the patients receiving systemic 
      retinoic acid therapy and to compare effectiveness of Autologous Serum (AS) and 
      preservative free artificial tear (PFAT) in the patients with dry eye disease. 
      METHOD: This prospective, crossover, double blind study was conducted on patients 
      who have dry eyes due to systemic isotretinoin treatment for different 
      indications. Patients detected as having dry eye during systemic isotretinoin 
      treatment were included to our study. At baseline, 1 and 2 month of study, 
      detailed ocular examination, best corrected visual acuity measurement, 
      intraocular pressure measurement, and Tear Break-up Time (TBUT) and Schirmer Test 
      (ST) without topical anesthesia were performed. We compared the efficacy of AS 
      and PFAT. To accomplish crossover after the first month, treatment given to each 
      patient was switched to the other treatment. Statistical analysis was measured 
      using SPSS version 20.0. p values of < 0.05 were considered as statistically 
      significant. RESULT: At the end of the first month, there was a significant 
      improvement for the TBUT test in both AS and PFAT groups compared to baseline 
      (respectively p < 0.001, p < 0.001). TBUT was found to be significantly higher in 
      the AS group compared to the PFAT group at the end of the first month (p < 
      0.001). At the end of the second month, TBUT was found to be significantly higher 
      in the AS group compared to the PFAT group at the posttreatment time (p < 0.001). 
      There was a significant OSDI score decreasing in both groups compared to that 
      reported previously at the end of the first and second months (respectively p < 
      0.001, p < 0.001). OSDI score decreasing was more significant in the AS group 
      compared to the PFAT group at both time points (respectively p < 0.001, p < 
      0.001). CONCLUSION: AS may be an effective alternative to PFAT in the treatment 
      of dry eye developed during isotretinoin use.
FAU - Yilmaz, Ugur
AU  - Yilmaz U
AD  - a Nigde State Hospital Opthalmology Clinic , Nigde , Turkey.
FAU - Kucuk, Erkut
AU  - Kucuk E
AD  - a Nigde State Hospital Opthalmology Clinic , Nigde , Turkey.
FAU - Koc, Cagdas
AU  - Koc C
AD  - b Nigde State Hospital Dermatology Clinic , Nigde , Turkey.
FAU - Gokler, Enes
AU  - Gokler E
AD  - c Sanliurfa Public Health Directorate , Sanliurfa , Turkey.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170131
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
RN  - 0 (Dermatologic Agents)
RN  - 0 (Lubricant Eye Drops)
RN  - 0 (Ophthalmic Solutions)
RN  - EH28UP18IF (Isotretinoin)
SB  - IM
MH  - Adult
MH  - Cross-Over Studies
MH  - Dermatologic Agents/administration & dosage
MH  - Double-Blind Method
MH  - Dry Eye Syndromes/chemically induced/diagnosis/*therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Isotretinoin/administration & dosage/*adverse effects
MH  - Lubricant Eye Drops/*administration & dosage
MH  - Male
MH  - Ophthalmic Solutions
MH  - Prospective Studies
MH  - *Serum
MH  - Skin Diseases/drug therapy
MH  - Tears/metabolism
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Acne vulgaris treatment
OT  - artificial serum
OT  - autologous serum
OT  - dry eye
OT  - isotretinoin
EDAT- 2017/02/01 06:00
MHDA- 2018/01/18 06:00
CRDT- 2017/02/01 06:00
PHST- 2017/02/01 06:00 [pubmed]
PHST- 2018/01/18 06:00 [medline]
PHST- 2017/02/01 06:00 [entrez]
AID - 10.1080/02713683.2016.1255758 [doi]
PST - ppublish
SO  - Curr Eye Res. 2017 Jun;42(6):827-831. doi: 10.1080/02713683.2016.1255758. Epub 
      2017 Jan 31.