PMID- 28141872
OWN - NLM
STAT- MEDLINE
DCOM- 20170809
LR  - 20190208
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 1
DP  - 2017
TI  - Factors Associated with the Retinal Nerve Fiber Layer Loss after Acute Primary 
      Angle Closure: A Prospective EDI-OCT Study.
PG  - e0168678
LID - 10.1371/journal.pone.0168678 [doi]
LID - e0168678
AB  - PURPOSE: To determine the factors associated with retinal nerve fiber layer 
      (RNFL) loss in eyes with acute primary angle-closure (APAC), particularly 
      focusing on the influence of the change in the anterior lamina cribrosa surface 
      depth (LCD). METHODS: After the initial presentation, 30 eyes with unilateral 
      APAC were followed up at the following specific time points over a 12-month 
      period: 1 week, 1~2 months, 2~3 months, 5~6 months, and 11~12 months. These 
      follow-ups involved intraocular pressure measurements, enhanced depth-imaging 
      spectral-domain optical coherence tomography (SD-OCT) scanning of the optic disc, 
      and measurements of the circumpapillary RNFL thickness. The prelaminar tissue 
      thickness (PLT) and LCD were determined in the SD-OCT images obtained at each 
      follow-up visit. RESULTS: Repeated measures analysis of variance revealed a 
      significant pattern of decrease in the global RNFL thickness, PLT, and LCD (all 
      p<0.001). The global RNFL thickness decreased continuously throughout the 
      follow-up period, while the PLT decreased until 5~6 months and did not change 
      thereafter. The LCD reduced until 2~3 months and then also remained steady. 
      Multivariable regression analysis revealed that symptoms with a longer duration 
      before receiving laser peripheral iridotomy (LI) (p = 0.049) and a larger LCD 
      reduction (p = 0.034) were significant factors associated with the conversion to 
      an abnormal RNFL thickness defined using OCT normative data. CONCLUSION: Early 
      short-term decreases in the PLT and LCD and overall long-term decrease in the 
      peripapillary RNFL were observed during a 12-month follow-up after an APAC 
      episode. A longer duration of symptoms before receiving LI treatment and larger 
      LCD reduction during follow-up were associated with the progressive RNFL loss. 
      The LCD reduction may indicate a prior presence of significant pressure-induced 
      stress that had been imposed on the optic nerve head at the time of APAC episode. 
      Glaucomatous progression should be suspected in eyes showing LCD reduction after 
      the APAC remission.
FAU - Lee, Eun Ji
AU  - Lee EJ
AUID- ORCID: 0000-0001-9393-9452
AD  - Department of Ophthalmology, Seoul National University College of Medicine, Seoul 
      National University Bundang Hospital, Seongnam, Korea.
FAU - Kim, Tae-Woo
AU  - Kim TW
AD  - Department of Ophthalmology, Seoul National University College of Medicine, Seoul 
      National University Bundang Hospital, Seongnam, Korea.
FAU - Lee, Kyoung Min
AU  - Lee KM
AD  - Department of Ophthalmology, Seoul National University College of Medicine, Seoul 
      National University Bundang Hospital, Seongnam, Korea.
FAU - Lee, Seung Hyen
AU  - Lee SH
AD  - Department of Ophthalmology, Seoul National University College of Medicine, Seoul 
      National University Bundang Hospital, Seongnam, Korea.
FAU - Kim, Hyunjoong
AU  - Kim H
AD  - Department of Applied Statistics, Yonsei University, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20170131
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Glaucoma, Angle-Closure/*pathology/physiopathology
MH  - Humans
MH  - Intraocular Pressure
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Optic Disk/pathology
MH  - Prospective Studies
MH  - Remission Induction
MH  - Retina/*pathology/physiopathology
MH  - Time Factors
MH  - Tomography, Optical Coherence/*methods
PMC - PMC5283663
COIS- The authors have declared that no competing interests exist.
EDAT- 2017/02/01 06:00
MHDA- 2017/08/10 06:00
PMCR- 2017/01/31
CRDT- 2017/02/01 06:00
PHST- 2016/05/18 00:00 [received]
PHST- 2016/12/05 00:00 [accepted]
PHST- 2017/02/01 06:00 [entrez]
PHST- 2017/02/01 06:00 [pubmed]
PHST- 2017/08/10 06:00 [medline]
PHST- 2017/01/31 00:00 [pmc-release]
AID - PONE-D-16-20031 [pii]
AID - 10.1371/journal.pone.0168678 [doi]
PST - epublish
SO  - PLoS One. 2017 Jan 31;12(1):e0168678. doi: 10.1371/journal.pone.0168678. 
      eCollection 2017.