PMID- 28143550
OWN - NLM
STAT- MEDLINE
DCOM- 20170626
LR  - 20181113
IS  - 1546-0096 (Electronic)
IS  - 1546-0096 (Linking)
VI  - 15
IP  - 1
DP  - 2017 Jan 31
TI  - Spectrum of paediatric rheumatic diseases in Nigeria.
PG  - 7
LID - 10.1186/s12969-017-0139-3 [doi]
LID - 7
AB  - BACKGROUND: Paediatric rheumatology service in Sub-Sahara African is virtually 
      not available as there is a shortage of paediatric rheumatologists and other 
      rheumatology health professionals. We aim to describe the clinical spectrum and 
      the frequencies of paediatric rheumatic diseases (PRDs) in Lagos State University 
      Teaching Hospital (LASUTH), Lagos, Nigeria. METHODS: This is a retrospective 
      review of patients with PRDs seen over a five year period (March 2010 to February 
      2016) at the rheumatology clinic and children ward of LASUTH. We reviewed the 
      folders of 57 patients from our records. The demographics, baseline laboratory 
      features, clinical diagnosis, treatment patterns and patient outcomes were 
      extracted and analyzed. Clinical and laboratory characteristics between patients 
      with Juvenile idiopathic arthritis (JIA) and patients with juvenile connective 
      tissue diseases (JCTD) were compared using Fisher's exact test. RESULTS: Fifty 
      seven patients were studied with a female to male ratio of 3 to 1 (Female: 43; M: 
      14). The mean age at presentation in years was 14 +/- 4.4 years (range: 1.5-22 
      years). The mean duration of symptoms before diagnosis was 18.4 +/- .9 months 
      (range: 2-60 months). The diagnostic types of PRDs included 28(49.1%) cases of 
      JIA. These were made up of 14 cases of polyarticular JIA, nine cases of 
      oligoarticular JIA and 5 cases of systemic onset JIA. Others were 18 (24.6%) 
      cases of juvenile systemic lupus erythematosus (JSLE), 3 (5.3%) cases of joint 
      hypermobility syndrome, 2 (3.5%) cases of juvenile systemic sclerosis, 2 (3.5%) 
      cases of fibromyalgia, 2 (3.5%) cases of plantar fasciitis, 1 (1.6%) case of 
      juvenile dermatomyositis (JDM), 1 (1.6%) case of juvenile polymyositis-systemic 
      lupus erythematosus (PM-SLE) overlap, 1 (1.6%) case of secondary bilateral knee 
      osteoarthritis from Blount disease, 1 (1.6%) case of secondary osteoporosis from 
      childhood leukemia and 1 (1.6%) case of Osgood-Schlatter's disease. 
      Constitutional symptoms and extra-articular diseases were significantly more 
      frequent among JCTD cases than among the JIA cases (Constitutional symptoms: 100% 
      vs 83.3%, p = 0.003; extra-articular disease: 100% vs 10.7%, p = 0.001). The 
      percentage mortality in this study was 10.5% while 20 (35.1%) of the patients 
      were lost to clinic follow up. CONCLUSION: The pattern of PRDs observed in this 
      study is similar to that described in South African and North American series but 
      it differs from patterns reported in Asian series. Although hitherto largely 
      unrecognized, PRDs may constitute a substantial cause of morbidity and mortality 
      in black Africans.
FAU - Olaosebikan, Babatunde Hakeem
AU  - Olaosebikan BH
AD  - Department of Medicine, Lagos State University Teaching Hospital, Ikeja, Lagos 
      State, Nigeria.
FAU - Adelowo, Olufemi Oladipo
AU  - Adelowo OO
AD  - Department of Medicine, Lagos State University Teaching Hospital, Ikeja, Lagos 
      State, Nigeria.
FAU - Animashaun, Barakat Adeola
AU  - Animashaun BA
AD  - Department of Paediatrics, Lagos State University Teaching Hospital, Ikeja, Lagos 
      State, Nigeria.
FAU - Akintayo, Richard Oluyinka
AU  - Akintayo RO
AD  - Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Kwara 
      State, Nigeria. richocounlimited@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20170131
PL  - England
TA  - Pediatr Rheumatol Online J
JT  - Pediatric rheumatology online journal
JID - 101248897
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Biological Factors)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adolescent
MH  - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
MH  - Biological Factors/therapeutic use
MH  - Biomarkers/metabolism
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Hospitalization/statistics & numerical data
MH  - Hospitals, Teaching/statistics & numerical data
MH  - Humans
MH  - Infant
MH  - Male
MH  - Nigeria/epidemiology
MH  - Retrospective Studies
MH  - Rheumatic Diseases/diagnosis/*epidemiology
MH  - Young Adult
PMC - PMC5282742
OTO - NOTNLM
OT  - Juvenile idiopathic arthritis
OT  - Juvenile systemic lupus erythematosus
OT  - Nigeria
OT  - Paediatric rheumatic disease
EDAT- 2017/02/02 06:00
MHDA- 2017/06/27 06:00
PMCR- 2017/01/31
CRDT- 2017/02/02 06:00
PHST- 2016/11/08 00:00 [received]
PHST- 2017/01/23 00:00 [accepted]
PHST- 2017/02/02 06:00 [entrez]
PHST- 2017/02/02 06:00 [pubmed]
PHST- 2017/06/27 06:00 [medline]
PHST- 2017/01/31 00:00 [pmc-release]
AID - 10.1186/s12969-017-0139-3 [pii]
AID - 139 [pii]
AID - 10.1186/s12969-017-0139-3 [doi]
PST - epublish
SO  - Pediatr Rheumatol Online J. 2017 Jan 31;15(1):7. doi: 10.1186/s12969-017-0139-3.