PMID- 28144260
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1734-1922 (Print)
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Linking)
VI  - 13
IP  - 1
DP  - 2017 Feb 1
TI  - The rs2228145 polymorphism in the interleukin-6 receptor and its association with 
      long-term prognosis after myocardial infarction in a pilot study.
PG  - 93-99
LID - 10.5114/aoms.2016.58636 [doi]
AB  - INTRODUCTION: Interleukin-6 (IL-6) is a cytokine with a complex function that is 
      described as both pro- and anti-inflammatory. One factor that influences its 
      function is the rs2228145 A/C single nucleotide polymorphism (SNP) of the IL-6 
      receptor (IL6R) gene. C allele carriers have a decreased inflammatory response 
      and decreased prevalence of ischemic heart disease. The aim of the study was to 
      investigate the association of the rs2228145 SNP of the IL6R gene with long-term 
      total mortality in patients with ST-elevation myocardial infarction (STEMI) 
      treated invasively. MATERIAL AND METHODS: We analyzed the data of consecutive 
      patients with ST elevation myocardial infarction (STEMI) treated with primary 
      percutaneous coronary intervention (PCI). Genotyping was performed with the 
      TaqMan method. The analyzed end-point was total long-term mortality (median: 2875 
      days). RESULTS: The registry comprised 553 patients (mean age: 62.4 +/-11.9 years; 
      25.6% females, n = 142; TIMI 3 obtained in 91.7% of patients, n = 507). No 
      significant differences in baseline characteristics were found between the 
      genotypes. During long-term follow-up 171 (30.9%) patients died. There was 
      non-significantly higher mortality in the rs2228145 AA homozygotes compared to C 
      allele carriers (OR = 1.34, 95% CI: 0.93-1.93, p = 0.1). CONCLUSIONS: The 
      rs2228145 polymorphism of IL6R was not significantly associated with long-term 
      mortality after STEMI. However, AA homozygotes (high-risk genotype for ischemic 
      heart disease) showed a trend towards adverse outcome compared to C allele 
      carriers. The observed trend is promising, but it requires independent 
      replication studies.
FAU - Szpakowicz, Anna
AU  - Szpakowicz A
AD  - Department of Cardiology, Medical University of Bialystok, Bialystok, Poland.
FAU - Pepinski, Witold
AU  - Pepinski W
AD  - Department of Forensic Medicine, Medical University of Bialystok, Bialystok, 
      Poland.
FAU - Waszkiewicz, Ewa
AU  - Waszkiewicz E
AD  - Department of Cardiology, Medical University of Bialystok, Bialystok, Poland.
FAU - Skawronska, Malgorzata
AU  - Skawronska M
AD  - Department of Forensic Medicine, Medical University of Bialystok, Bialystok, 
      Poland.
FAU - Niemcunowicz-Janica, Anna
AU  - Niemcunowicz-Janica A
AD  - Department of Forensic Medicine, Medical University of Bialystok, Bialystok, 
      Poland.
FAU - Musial, Wlodzimierz J
AU  - Musial WJ
AD  - Department of Cardiology, Medical University of Bialystok, Bialystok, Poland.
FAU - Kaminski, Karol A
AU  - Kaminski KA
AD  - Department of Cardiology, Medical University of Bialystok, Bialystok, Poland.
LA  - eng
PT  - Journal Article
DEP - 20160317
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC5206359
OTO - NOTNLM
OT  - IL-6 receptor
OT  - ST elevation myocardial infarction
OT  - acute coronary syndrome
OT  - interleukin-6
COIS- The authors declare no conflict of interest.
EDAT- 2017/02/02 06:00
MHDA- 2017/02/02 06:01
PMCR- 2017/02/01
CRDT- 2017/02/02 06:00
PHST- 2015/04/08 00:00 [received]
PHST- 2015/06/01 00:00 [accepted]
PHST- 2017/02/02 06:00 [entrez]
PHST- 2017/02/02 06:00 [pubmed]
PHST- 2017/02/02 06:01 [medline]
PHST- 2017/02/01 00:00 [pmc-release]
AID - 27140 [pii]
AID - 10.5114/aoms.2016.58636 [doi]
PST - ppublish
SO  - Arch Med Sci. 2017 Feb 1;13(1):93-99. doi: 10.5114/aoms.2016.58636. Epub 2016 Mar 
      17.