PMID- 28144463
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2074-1804 (Print)
IS  - 2074-1812 (Electronic)
IS  - 2074-1804 (Linking)
VI  - 18
IP  - 9
DP  - 2016 Sep
TI  - Drug Reaction With Eosinophilia and Systemic Symptoms Induced by Valproic Acid: A 
      Case Report.
PG  - e36825
LID - 10.5812/ircmj.36825 [doi]
LID - e36825
AB  - INTRODUCTION: Drug reaction with eosinophilia and systemic symptoms (DRESS) 
      syndrome is a rare but life-threatening reaction to drugs such as carbamazepine 
      and allopurinol. The condition is characterized by skin rashes, fever, 
      hematological disturbances, lymphadenopathy, and organ failure, most probably 
      hepatic dysfunction. To date, only a few cases of valproate-induced DRESS 
      syndrome have been reported. CASE PRESENTATION: We report on the case of a 
      60-year-old man who had been treated with valproic acid some time before being 
      referred to Kowsar Hospital, Semnan, Iran in December 2015. He was given valproic 
      acid 1000 mg PO, and after 20 days, he had developed widespread rashes, fever, 
      esophagitis, cervical lymphadenopathy, and tender hepatomegaly. Laboratory 
      results at Kowsar showed a drop in hemoglobin, in addition to lymphocytosis, 
      thrombocytopenia, and elevated serum transaminases. DRESS was diagnosed, and 
      corticosteroid therapy was initiated. Administration of the culprit drug to the 
      patient was also stopped. Intravenous immunoglobulin (IVIG) improved the general 
      condition of the patient. CONCLUSIONS: Only a small number of case reports have 
      described valproic acid-induced DRESS syndrome; therefore, the condition is 
      difficult to prevent. Rechallenge with valproic acid should be avoided in 
      patients with a history of reaction to the drug.
FAU - Darban, Mahboubeh
AU  - Darban M
AD  - Department of Internal Medicine, Kowsar Hospital, Semnan University of Medical 
      Sciences, Semnan, IR Iran.
FAU - Bagheri, Bahador
AU  - Bagheri B
AD  - Cancer Research Center and Department of Pharmacology, Semnan University of 
      Medical Sciences, Semnan, IR Iran.
LA  - eng
PT  - Case Reports
DEP - 20160806
PL  - Estonia
TA  - Iran Red Crescent Med J
JT  - Iranian Red Crescent medical journal
JID - 101319850
PMC - PMC5253700
OTO - NOTNLM
OT  - DRESS
OT  - Fever
OT  - Liver
OT  - Rash
OT  - Valproic Acid
EDAT- 2017/02/02 06:00
MHDA- 2017/02/02 06:01
PMCR- 2016/09/01
CRDT- 2017/02/02 06:00
PHST- 2016/02/01 00:00 [received]
PHST- 2016/03/28 00:00 [revised]
PHST- 2016/05/01 00:00 [accepted]
PHST- 2017/02/02 06:00 [entrez]
PHST- 2017/02/02 06:00 [pubmed]
PHST- 2017/02/02 06:01 [medline]
PHST- 2016/09/01 00:00 [pmc-release]
AID - 10.5812/ircmj.36825 [doi]
PST - epublish
SO  - Iran Red Crescent Med J. 2016 Aug 6;18(9):e36825. doi: 10.5812/ircmj.36825. 
      eCollection 2016 Sep.