PMID- 28144895
OWN - NLM
STAT- MEDLINE
DCOM- 20170913
LR  - 20181113
IS  - 1867-108X (Electronic)
IS  - 1867-1071 (Linking)
VI  - 35
IP  - 4
DP  - 2017 Apr
TI  - Abnormal regional homogeneity and functional connectivity in adjustment disorder 
      of new recruits: a resting-state fMRI study.
PG  - 151-160
LID - 10.1007/s11604-017-0614-2 [doi]
AB  - PURPOSE: To explore the regional spontaneous neural activity and functional 
      connectivity alterations of adjustment disorder (AD) in new recruits with in vivo 
      resting-state functional MR (rs-fMRI). MATERIALS AND METHODS: Resting-state fMRI 
      was performed in 31 recruits with AD and in 31 control recruits. Regional 
      homogeneity (ReHo) was used to detect the regional synchronizing features of 
      neuronal activations. Correlative analysis was performed to investigate the 
      relationship between the Symptom Check List-90 (SCL-90) score and ReHo in regions 
      with significant group differences. Regions with significant correlation were 
      then defined as regions of interest (ROIs), and seed-ROI based whole-brain 
      functional connectivity was performed. RESULTS: Compared with the controls, 
      patients with AD had significantly lower ReHo in the left posterior cerebellar 
      lobe, bilateral medial orbitofrontal cortex, bilateral caudate and left middle 
      temporal gyrus, whereas regions with enhanced ReHo were confined to bilateral 
      posterior cingulate gyrus/precuneus. Only the left posterior cerebellar lobe 
      showed significant correlation between ReHo and the SCL-90 score, and was defined 
      as the seed ROI. Decreased functional connectivity was found between the ROI and 
      bilateral supplementary motor area. CONCLUSION: This study reveals abnormalities 
      in recruits with AD in baseline brain function activities, which could further 
      improve our understanding of the neural substrates of cognitive impairment in AD.
FAU - Li, Hui
AU  - Li H
AD  - Department of Medical Imaging, Fuzhou General Hospital, Second Military Medical 
      University, No.156, West Erhuan Road, Fuzhou, 350025, Fujian, China.
FAU - Lin, Yuning
AU  - Lin Y
AD  - Department of Medical Imaging, Fuzhou General Hospital, Second Military Medical 
      University, No.156, West Erhuan Road, Fuzhou, 350025, Fujian, China.
FAU - Chen, Ji
AU  - Chen J
AD  - Department of Medical Imaging, Fuzhou General Hospital, Second Military Medical 
      University, No.156, West Erhuan Road, Fuzhou, 350025, Fujian, China.
FAU - Wang, Xiaoyang
AU  - Wang X
AD  - Department of Medical Imaging, Fuzhou General Hospital, Second Military Medical 
      University, No.156, West Erhuan Road, Fuzhou, 350025, Fujian, China.
FAU - Wu, Qingqing
AU  - Wu Q
AD  - Department of Medical Imaging, Fuzhou General Hospital, Second Military Medical 
      University, No.156, West Erhuan Road, Fuzhou, 350025, Fujian, China.
FAU - Li, Qi
AU  - Li Q
AD  - Department of Psychiatry, Fuzhou General Hospital, Second Military Medical 
      University, No.156, West Erhuan Road, Fuzhou, 350025, Fujian, China.
FAU - Chen, Ziqian
AU  - Chen Z
AD  - Department of Medical Imaging, Fuzhou General Hospital, Second Military Medical 
      University, No.156, West Erhuan Road, Fuzhou, 350025, Fujian, China. 
      czq_radiology@163.com.
LA  - eng
PT  - Journal Article
DEP - 20170131
PL  - Japan
TA  - Jpn J Radiol
JT  - Japanese journal of radiology
JID - 101490689
SB  - IM
MH  - Adjustment Disorders/*diagnostic imaging/*physiopathology/psychology
MH  - Adolescent
MH  - Adult
MH  - Brain/diagnostic imaging/physiopathology
MH  - Case-Control Studies
MH  - Cerebellum/diagnostic imaging/physiopathology
MH  - Functional Laterality
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Military Personnel/*psychology
MH  - Neural Pathways/diagnostic imaging/physiopathology
MH  - Young Adult
OTO - NOTNLM
OT  - Adjustment disorder
OT  - Functional connectivity
OT  - New recruits
OT  - Regional homogeneity
OT  - Resting state fMRI
EDAT- 2017/02/02 06:00
MHDA- 2017/09/14 06:00
CRDT- 2017/02/02 06:00
PHST- 2016/08/31 00:00 [received]
PHST- 2017/01/06 00:00 [accepted]
PHST- 2017/02/02 06:00 [pubmed]
PHST- 2017/09/14 06:00 [medline]
PHST- 2017/02/02 06:00 [entrez]
AID - 10.1007/s11604-017-0614-2 [pii]
AID - 10.1007/s11604-017-0614-2 [doi]
PST - ppublish
SO  - Jpn J Radiol. 2017 Apr;35(4):151-160. doi: 10.1007/s11604-017-0614-2. Epub 2017 
      Jan 31.