PMID- 28145793
OWN - NLM
STAT- MEDLINE
DCOM- 20180821
LR  - 20181202
IS  - 1097-9867 (Electronic)
IS  - 1083-7450 (Linking)
VI  - 23
IP  - 4
DP  - 2018 Apr
TI  - Development and characterization of poly(lactic-co-glycolic) acid nanoparticles 
      loaded with copaiba oleoresin.
PG  - 343-350
LID - 10.1080/10837450.2017.1290107 [doi]
AB  - Copaiba oleoresin (CPO), obtained from Copaifera landgroffii, is described as 
      active to a large number of diseases and more recently in the endometriosis 
      treatment. In this work, poly(lactic-co-glycolic acid) (PLGA) nanoparticles 
      containing CPO were obtained using the design of experiments (DOE) as a tool to 
      optimize the production process. The nanoparticles optimized by means of DOE 
      presented an activity in relation to the cellular viability of endometrial cells. 
      The DOE showed that higher amounts of CPO combined with higher surfactant 
      concentrations resulted in better encapsulation efficiency and size distribution 
      along with good stability after freeze drying. The encapsulation efficiency was 
      over 80% for all produced nanoparticles, which also presented sizes below 300 nm 
      and spherical shape. A decrease in viability of endometrial stromal cells from 
      ectopic endometrium of patients with endometriosis and from eutopic endometriotic 
      lesions was demonstrated after 48 h of incubation with the CPO nanoparticles. The 
      nanoparticles without CPO were not able to alter the cell viability of the same 
      cells, indicating that this material was not cytotoxic to the tested cells and 
      suggesting that the effect was specific to CPO. The results indicate that the use 
      of CPO nanoparticles may represent a promising alternative for the treatment of 
      endometriosis.
FAU - de Almeida Borges, Vinicius Raphael
AU  - de Almeida Borges VR
AD  - a Department of Pharmaceutics , Federal University of Rio de Janeiro , Rio de 
      Janeiro , Brazil.
FAU - Tavares, Marina R
AU  - Tavares MR
AD  - a Department of Pharmaceutics , Federal University of Rio de Janeiro , Rio de 
      Janeiro , Brazil.
FAU - da Silva, Julianna Henriques
AU  - da Silva JH
AD  - b Research Program in Cellular Biology and Development, Institute of Biomedical 
      Sciences, Federal University of Rio de Janeiro , Rio de Janeiro , Brazil.
FAU - Tajber, Lidia
AU  - Tajber L
AD  - c School of Pharmacy, Trinity College, University of Dublin , Dublin , Ireland.
FAU - Boylan, Fabio
AU  - Boylan F
AD  - c School of Pharmacy, Trinity College, University of Dublin , Dublin , Ireland.
FAU - Ribeiro, Ana Ferreira
AU  - Ribeiro AF
AD  - a Department of Pharmaceutics , Federal University of Rio de Janeiro , Rio de 
      Janeiro , Brazil.
FAU - Nasciutti, Luiz Eurico
AU  - Nasciutti LE
AD  - b Research Program in Cellular Biology and Development, Institute of Biomedical 
      Sciences, Federal University of Rio de Janeiro , Rio de Janeiro , Brazil.
FAU - Cabral, Lucio Mendes
AU  - Cabral LM
AD  - a Department of Pharmaceutics , Federal University of Rio de Janeiro , Rio de 
      Janeiro , Brazil.
FAU - de Sousa, Valeria Pereira
AU  - de Sousa VP
AD  - a Department of Pharmaceutics , Federal University of Rio de Janeiro , Rio de 
      Janeiro , Brazil.
LA  - eng
PT  - Journal Article
DEP - 20170220
PL  - England
TA  - Pharm Dev Technol
JT  - Pharmaceutical development and technology
JID - 9610932
RN  - 0 (Drug Carriers)
RN  - 0 (Plant Preparations)
RN  - 0 (copaiba oleoresin)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Drug Carriers/*chemistry
MH  - Endometriosis/drug therapy
MH  - Fabaceae/chemistry
MH  - Female
MH  - Freeze Drying
MH  - Humans
MH  - Lactic Acid/*chemistry
MH  - Nanoparticles/*chemistry
MH  - Particle Size
MH  - Plant Preparations/*administration & dosage/chemistry/pharmacology
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
OTO - NOTNLM
OT  - Copaiba oleoresin
OT  - Copaifera landgroffii
OT  - PLGA
OT  - design of experiments
OT  - endometriosis
OT  - nanoparticles
EDAT- 2017/02/02 06:00
MHDA- 2018/08/22 06:00
CRDT- 2017/02/02 06:00
PHST- 2017/02/02 06:00 [pubmed]
PHST- 2018/08/22 06:00 [medline]
PHST- 2017/02/02 06:00 [entrez]
AID - 10.1080/10837450.2017.1290107 [doi]
PST - ppublish
SO  - Pharm Dev Technol. 2018 Apr;23(4):343-350. doi: 10.1080/10837450.2017.1290107. 
      Epub 2017 Feb 20.