PMID- 28146109 OWN - NLM STAT- MEDLINE DCOM- 20170926 LR - 20181113 IS - 1999-4915 (Electronic) IS - 1999-4915 (Linking) VI - 9 IP - 2 DP - 2017 Jan 30 TI - The Characteristics of Herpes Simplex Virus Type 1 Infection in Rhesus Macaques and the Associated Pathological Features. LID - 10.3390/v9020026 [doi] LID - 26 AB - As one of the major pathogens for human herpetic diseases, herpes simplex virus type 1 (HSV1) causes herpes labialis, genital herpes and herpetic encephalitis. Our aim here was to investigate the infectious process of HSV1 in rhesus macaques and the pathological features induced during this infection. Clinical symptoms that manifested in the rhesus macaque during HSV1 infection included vesicular lesions and their pathological features. Viral distribution in the nervous tissues and associated pathologic changes indicated the typical systematic pathological processes associated with viral distribution of HSV1.Interestingly, vesicular lesions recurred in oral skin or in mucosa associated with virus shedding in macaques within four to five months post-infection,and viral latency-associated transcript (LAT) mRNA was found in the trigeminal ganglia (TG)on day 365 post-infection. Neutralization testing and enzyme-linked immunospot (ELISpot) detection of specific T cell responses confirmed the specific immunity induced by HSV1 infection. Thus, rhesus macaques could serve as an infectious model for HSV1 due to their typical clinical symptoms and the pathological recurrence associated with viral latency in nervous tissues. FAU - Fan, Shengtao AU - Fan S AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming 650118, China. fst@imbcams.com.cn. FAU - Cai, Hongzhi AU - Cai H AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming 650118, China. fst0007@163.com. FAU - Xu, Xingli AU - Xu X AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming 650118, China. xinglixu@imbcams.com.cn. FAU - Feng, Min AU - Feng M AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming 650118, China. fengmin@imbcams.com.cn. FAU - Wang, Lichun AU - Wang L AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming 650118, China. wlc@imbcams.com.cn. FAU - Liao, Yun AU - Liao Y AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming 650118, China. liaoyun@imbcams.com.cn. FAU - Zhang, Ying AU - Zhang Y AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming 650118, China. zhangy@imbcams.com.cn. FAU - He, Zhanlong AU - He Z AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China. hzl@imbcams.com.cn. FAU - Yang, Fengmei AU - Yang F AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China. yangfenmei@imbcams.com.cn. FAU - Yu, Wenhai AU - Yu W AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China. wenhaiyu@imbcams.com.cn. FAU - Wang, Jingjing AU - Wang J AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming 650118, China. wangjingjing@imbcams.com.cn. FAU - Zhou, Jumin AU - Zhou J AD - Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China. zhoujm@mail.kiz.ac.cn. FAU - Li, Qihan AU - Li Q AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming 650118, China. liqihan@imbcams.com.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20170130 PL - Switzerland TA - Viruses JT - Viruses JID - 101509722 RN - 0 (Antibodies, Neutralizing) RN - 0 (Antibodies, Viral) SB - IM MH - Animal Structures/virology MH - Animals MH - Antibodies, Neutralizing/blood MH - Antibodies, Viral/blood MH - *Disease Models, Animal MH - Enzyme-Linked Immunospot Assay MH - Herpes Simplex/immunology/*pathology/*virology MH - Herpesvirus 1, Human/immunology/*isolation & purification MH - Macaca mulatta MH - Neutralization Tests MH - T-Lymphocytes/immunology PMC - PMC5332945 OTO - NOTNLM OT - herpes simplex virus type 1 OT - pathology OT - rhesus macaques COIS- The authors declare no conflict of interest. EDAT- 2017/02/02 06:00 MHDA- 2017/09/28 06:00 PMCR- 2017/02/01 CRDT- 2017/02/02 06:00 PHST- 2016/11/17 00:00 [received] PHST- 2017/01/24 00:00 [accepted] PHST- 2017/02/02 06:00 [entrez] PHST- 2017/02/02 06:00 [pubmed] PHST- 2017/09/28 06:00 [medline] PHST- 2017/02/01 00:00 [pmc-release] AID - v9020026 [pii] AID - viruses-09-00026 [pii] AID - 10.3390/v9020026 [doi] PST - epublish SO - Viruses. 2017 Jan 30;9(2):26. doi: 10.3390/v9020026.