PMID- 28147245
OWN - NLM
STAT- MEDLINE
DCOM- 20171120
LR  - 20211204
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 346
DP  - 2017 Mar 27
TI  - Angiotensin-(1-7) administration attenuates Alzheimer's disease-like 
      neuropathology in rats with streptozotocin-induced diabetes via Mas receptor 
      activation.
PG  - 267-277
LID - S0306-4522(17)30040-4 [pii]
LID - 10.1016/j.neuroscience.2017.01.027 [doi]
AB  - Diabetes mellitus (DM) is associated with cognitive deficits and an increased 
      risk of Alzheimer's disease (AD). Recently, a newly identified heptapeptide of 
      the renin-angiotensin system (RAS), angiotensin-(1-7) [Ang-(1-7)], was found to 
      protect against brain damage. This study investigated the effects of Ang-(1-7) on 
      diabetes-induced cognitive deficits. Sprague-Dawley rats were randomly divided 
      into four groups. Diabetes was induced via single i.p. streptozotocin (STZ) 
      injections. Ten weeks after diabetes induction, rats in each group received an 
      intracerebral-ventricular (ICV) infusion of either vehicle, Ang-(1-7) alone, or 
      Ang-(1-7)+A779 daily for two weeks. At the end of the study, Morris water maze 
      (MWM) tests were performed to test cognitive functions before the rats were 
      euthanized. Ang-(1-7) treatment significantly reduced escape latencies in 
      diabetic rats in acquisition trials and markedly enhanced platform area crossing 
      frequency and time spent in the target quadrant in probe trials (3.0+/-0.39 vs. 
      1.0+/-0.33, 39.39+/-1.11% vs. 25.62+/-3.07%, respectively, P<0.01). Ang-(1-7) treatment 
      ameliorated damage to the ultrastructure of hippocampal synapses, reduced the 
      expression of hippocampal phospho-tau at Ser396 (P<0.01), Ser404 (P<0.01) and 
      Ser202/Thr205 (P<0.05), and decreased amyloid-beta oligomer and both soluble and 
      insoluble beta-amyloid peptide 1-42 (Abeta 1-42) and Abeta 1-40 levels (P<0.01). These 
      protective effects were significantly reversed by the co-administration of A779. 
      These findings show that Ang-(1-7) is a promising therapeutic target for 
      diabetes-induced cognitive impairment. The neuroprotective effects of Ang-(1-7) 
      were mainly through Mas receptor (MasR) activation.
CI  - Copyright (c) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Chen, Jin-Liang
AU  - Chen JL
AD  - Department of Geriatrics, the First Affiliated Hospital of Chongqing Medical 
      University, Friendship Road 1, Yuan Jiagang, 400016 Chongqing, China.
FAU - Zhang, Dong-Ling
AU  - Zhang DL
AD  - Department of Geriatrics, the First Affiliated Hospital of Chongqing Medical 
      University, Friendship Road 1, Yuan Jiagang, 400016 Chongqing, China.
FAU - Sun, Yue
AU  - Sun Y
AD  - Department of Geriatrics, the First Affiliated Hospital of Chongqing Medical 
      University, Friendship Road 1, Yuan Jiagang, 400016 Chongqing, China.
FAU - Zhao, Yu-Xing
AU  - Zhao YX
AD  - Department of Geriatrics, the First Affiliated Hospital of Chongqing Medical 
      University, Friendship Road 1, Yuan Jiagang, 400016 Chongqing, China.
FAU - Zhao, Ke-Xiang
AU  - Zhao KX
AD  - Department of Geriatrics, the First Affiliated Hospital of Chongqing Medical 
      University, Friendship Road 1, Yuan Jiagang, 400016 Chongqing, China.
FAU - Pu, Die
AU  - Pu D
AD  - Department of Geriatrics, the First Affiliated Hospital of Chongqing Medical 
      University, Friendship Road 1, Yuan Jiagang, 400016 Chongqing, China.
FAU - Xiao, Qian
AU  - Xiao Q
AD  - Department of Geriatrics, the First Affiliated Hospital of Chongqing Medical 
      University, Friendship Road 1, Yuan Jiagang, 400016 Chongqing, China. Electronic 
      address: xiaoqian1956@126.com.
LA  - eng
PT  - Journal Article
DEP - 20170129
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Mapt protein, rat)
RN  - 0 (Peptide Fragments)
RN  - 0 (Proto-Oncogene Mas)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (tau Proteins)
RN  - 5W494URQ81 (Streptozocin)
RN  - 9041-90-1 (Angiotensin I)
RN  - IJ3FUK8MOF (angiotensin I (1-7))
SB  - IM
MH  - Alzheimer Disease/*pathology/*prevention & control/psychology
MH  - Angiotensin I/*administration & dosage
MH  - Animals
MH  - Diabetes Mellitus, Experimental/*pathology/*prevention & control/psychology
MH  - Hippocampus/drug effects/metabolism/ultrastructure
MH  - Male
MH  - Peptide Fragments/*administration & dosage
MH  - Phosphorylation
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogene Proteins/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, G-Protein-Coupled/metabolism
MH  - Streptozocin
MH  - Synapses/drug effects/ultrastructure
MH  - tau Proteins/metabolism
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - amyloid-beta
OT  - angiotensin-(1-7)
OT  - diabetes mellitus
OT  - tau
EDAT- 2017/02/02 06:00
MHDA- 2017/11/29 06:00
CRDT- 2017/02/02 06:00
PHST- 2016/08/04 00:00 [received]
PHST- 2017/01/16 00:00 [revised]
PHST- 2017/01/17 00:00 [accepted]
PHST- 2017/02/02 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2017/02/02 06:00 [entrez]
AID - S0306-4522(17)30040-4 [pii]
AID - 10.1016/j.neuroscience.2017.01.027 [doi]
PST - ppublish
SO  - Neuroscience. 2017 Mar 27;346:267-277. doi: 10.1016/j.neuroscience.2017.01.027. 
      Epub 2017 Jan 29.