PMID- 28148726
OWN - NLM
STAT- MEDLINE
DCOM- 20170821
LR  - 20200225
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 37
IP  - 10
DP  - 2017 Mar 8
TI  - Synchronous Infra-Slow Bursting in the Mouse Accessory Olfactory Bulb Emerge from 
      Interplay between Intrinsic Neuronal Dynamics and Network Connectivity.
PG  - 2656-2672
LID - 10.1523/JNEUROSCI.3107-16.2017 [doi]
AB  - Rhythmic neuronal activity of multiple frequency bands has been described in many 
      brain areas and attributed to numerous brain functions. Among these, little is 
      known about the mechanism and role of infra-slow oscillations, which have been 
      demonstrated recently in the mouse accessory olfactory bulb (AOB). Along with 
      prolonged responses to stimuli and distinct network connectivity, they 
      inexplicably affect the AOB processing of social relevant stimuli. Here, we show 
      that assemblies of AOB mitral cells are synchronized by lateral interactions 
      through chemical and electrical synapses. Using a network model, we demonstrate 
      that the synchronous oscillations in these assemblies emerge from interplay 
      between intrinsic membrane properties and network connectivity. As a consequence, 
      the AOB network topology, in which each mitral cell receives input from multiple 
      glomeruli, enables integration of chemosensory stimuli over extended time scales 
      by interglomerular synchrony of infra-slow bursting. These results provide a 
      possible functional significance for the distinct AOB physiology and topology. 
      Beyond the AOB, this study presents a general model for synchronous infra-slow 
      bursting in neuronal networks.SIGNIFICANCE STATEMENT Infra-slow rhythmic neuronal 
      activity with a very long (>10 s) duration has been described in many brain 
      areas, but little is known about the role of this activity and the mechanisms 
      that produce it. Here, we combine experimental and computational methods to show 
      that synchronous infra-slow bursting activity in mitral cells of the mouse 
      accessory olfactory bulb (AOB) emerges from interplay between intracellular 
      dynamics and network connectivity. In this novel mechanism, slow intracellular 
      Na(+) dynamics endow AOB mitral cells with a weak tendency to burst, which is 
      further enhanced and stabilized by chemical and electrical synapses between them. 
      Combined with the unique topology of the AOB network, infra-slow bursting enables 
      integration and binding of multiple chemosensory stimuli over a prolonged time 
      scale.
CI  - Copyright (c) 2017 the authors 0270-6474/17/372656-17$15.00/0.
FAU - Zylbertal, Asaph
AU  - Zylbertal A
AUID- ORCID: 0000-0002-9789-2468
AD  - Department of Neurobiology, Institute of Life Sciences, Hebrew University and the 
      Edmond and Lily Safra Center for Brain Sciences, Jerusalem 9190401, Israel, and 
      asaph.zylbertal@mail.huji.ac.il.
FAU - Yarom, Yosef
AU  - Yarom Y
AUID- ORCID: 0000-0002-5483-1972
AD  - Department of Neurobiology, Institute of Life Sciences, Hebrew University and the 
      Edmond and Lily Safra Center for Brain Sciences, Jerusalem 9190401, Israel, and.
FAU - Wagner, Shlomo
AU  - Wagner S
AUID- ORCID: 0000-0002-7618-0752
AD  - Sagol Department of Neurobiology, University of Haifa, Haifa 31905, Israel.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170201
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Action Potentials/*physiology
MH  - Animals
MH  - Biological Clocks/*physiology
MH  - Connectome/methods
MH  - Cortical Synchronization/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nerve Net/*physiology
MH  - Neural Pathways/physiology
MH  - Neurons/*physiology
MH  - Olfactory Bulb/*physiology
PMC - PMC6596634
OTO - NOTNLM
OT  - AOB
OT  - calcium imaging
OT  - infra-slow bursting
OT  - mouse
OT  - network model
OT  - sensory integration
EDAT- 2017/02/06 06:00
MHDA- 2017/08/22 06:00
PMCR- 2017/09/08
CRDT- 2017/02/03 06:00
PHST- 2016/10/06 00:00 [received]
PHST- 2017/01/12 00:00 [revised]
PHST- 2017/01/16 00:00 [accepted]
PHST- 2017/02/06 06:00 [pubmed]
PHST- 2017/08/22 06:00 [medline]
PHST- 2017/02/03 06:00 [entrez]
PHST- 2017/09/08 00:00 [pmc-release]
AID - JNEUROSCI.3107-16.2017 [pii]
AID - 3107-16 [pii]
AID - 10.1523/JNEUROSCI.3107-16.2017 [doi]
PST - ppublish
SO  - J Neurosci. 2017 Mar 8;37(10):2656-2672. doi: 10.1523/JNEUROSCI.3107-16.2017. 
      Epub 2017 Feb 1.