PMID- 28150869
OWN - NLM
STAT- MEDLINE
DCOM- 20171020
LR  - 20181113
IS  - 1554-527X (Electronic)
IS  - 0736-0266 (Print)
IS  - 0736-0266 (Linking)
VI  - 35
IP  - 10
DP  - 2017 Oct
TI  - Biochemical markers of cartilage metabolism are associated with walking 
      biomechanics 6-months following anterior cruciate ligament reconstruction.
PG  - 2288-2297
LID - 10.1002/jor.23534 [doi]
AB  - The purpose of our study was to determine the association between biomechanical 
      outcomes of walking gait (peak vertical ground reaction force [vGRF], vGRF 
      loading rate [vGRF-LR], and knee adduction moment [KAM]) 6 months following 
      anterior cruciate ligament reconstruction (ACLR) and biochemical markers of serum 
      type-II collagen turnover (collagen type-II cleavage product to collagen type-II 
      C-propeptide [C2C:CPII]), plasma degenerative enzymes (matrix metalloproteinase-3 
      [MMP-3]), and a pro-inflammatory cytokine (interleukin-6 [IL-6]). Biochemical 
      markers were evaluated within the first 2 weeks (6.5 +/- 3.8 days) following ACL 
      injury and again 6 months following ACLR in eighteen participants. All peak 
      biomechanical outcomes were extracted from the first 50% of the stance phase of 
      walking gait during a 6-month follow-up exam. Limb symmetry indices (LSI) were 
      used to normalize the biomechanical outcomes in the ACLR limb to that of the 
      contralateral limb (ACLR/contralateral). Bivariate correlations were used to 
      assess associations between biomechanical and biochemical outcomes. Greater 
      plasma MMP-3 concentrations after ACL injury and at the 6-month follow-up exam 
      were associated with lesser KAM LSI. Lesser KAM was associated with greater 
      plasma IL-6 at the 6-month follow-up exam. Similarly, lesser vGRF-LR LSI was 
      associated with greater plasma MMP-3 concentrations at the 6-month follow-up 
      exam. Lesser peak vGRF LSI was associated with higher C2C:CPII after ACL injury, 
      yet this association was not significant after accounting for walking speed. 
      Therefore, lesser biomechanical loading in the ACLR limb, compared to the 
      contralateral limb, 6 months following ACLR may be related to deleterious joint 
      tissue metabolism that could influence future cartilage breakdown. (c) 2017 
      Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 
      35:2288-2297, 2017.
CI  - (c) 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
FAU - Pietrosimone, Brian
AU  - Pietrosimone B
AD  - Department of Exercise and Sport Science, University of North Carolina at Chapel 
      Hill, Chapel Hill, North Carolina.
AD  - Human Movement Science Curriculum, University of North Carolina at Chapel Hill, 
      Chapel Hill, North Carolina.
FAU - Loeser, Richard F
AU  - Loeser RF
AD  - Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, 
      Chapel Hill, North Carolina.
FAU - Blackburn, J Troy
AU  - Blackburn JT
AD  - Department of Exercise and Sport Science, University of North Carolina at Chapel 
      Hill, Chapel Hill, North Carolina.
AD  - Human Movement Science Curriculum, University of North Carolina at Chapel Hill, 
      Chapel Hill, North Carolina.
FAU - Padua, Darin A
AU  - Padua DA
AD  - Department of Exercise and Sport Science, University of North Carolina at Chapel 
      Hill, Chapel Hill, North Carolina.
AD  - Human Movement Science Curriculum, University of North Carolina at Chapel Hill, 
      Chapel Hill, North Carolina.
FAU - Harkey, Matthew S
AU  - Harkey MS
AD  - Human Movement Science Curriculum, University of North Carolina at Chapel Hill, 
      Chapel Hill, North Carolina.
FAU - Stanley, Laura E
AU  - Stanley LE
AD  - Human Movement Science Curriculum, University of North Carolina at Chapel Hill, 
      Chapel Hill, North Carolina.
FAU - Luc-Harkey, Brittney A
AU  - Luc-Harkey BA
AD  - Human Movement Science Curriculum, University of North Carolina at Chapel Hill, 
      Chapel Hill, North Carolina.
FAU - Ulici, Veronica
AU  - Ulici V
AD  - Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, 
      Chapel Hill, North Carolina.
FAU - Marshall, Stephen W
AU  - Marshall SW
AD  - Injury Prevention Research Center, University of North Carolina at Chapel Hill, 
      North Carolina.
FAU - Jordan, Joanne M
AU  - Jordan JM
AD  - Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, 
      Chapel Hill, North Carolina.
FAU - Spang, Jeffery T
AU  - Spang JT
AD  - Department of Orthopaedics, School of Medicine, University of North Carolina at 
      Chapel Hill, North Carolina.
LA  - eng
GR  - R03 AR066840/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20170302
PL  - United States
TA  - J Orthop Res
JT  - Journal of orthopaedic research : official publication of the Orthopaedic 
      Research Society
JID - 8404726
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Anterior Cruciate Ligament Reconstruction
MH  - Biomarkers/*blood
MH  - Biomechanical Phenomena
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Knee Joint/*physiology
MH  - Male
MH  - Walking/*physiology
MH  - Weight-Bearing
MH  - Young Adult
PMC - PMC5540809
MID - NIHMS848548
OTO - NOTNLM
OT  - collagen
OT  - interleukin
OT  - knee adduction moment
OT  - matrix metalloproteinase-3
OT  - osteoarthritis
EDAT- 2017/02/06 06:00
MHDA- 2017/10/21 06:00
PMCR- 2018/10/01
CRDT- 2017/02/03 06:00
PHST- 2016/07/06 00:00 [received]
PHST- 2017/01/23 00:00 [accepted]
PHST- 2017/02/06 06:00 [pubmed]
PHST- 2017/10/21 06:00 [medline]
PHST- 2017/02/03 06:00 [entrez]
PHST- 2018/10/01 00:00 [pmc-release]
AID - 10.1002/jor.23534 [doi]
PST - ppublish
SO  - J Orthop Res. 2017 Oct;35(10):2288-2297. doi: 10.1002/jor.23534. Epub 2017 Mar 2.