PMID- 28151958
OWN - NLM
STAT- MEDLINE
DCOM- 20170821
LR  - 20190208
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 2
DP  - 2017
TI  - Effects of acute and chronic exercise on the osmotic stability of erythrocyte 
      membrane of competitive swimmers.
PG  - e0171318
LID - 10.1371/journal.pone.0171318 [doi]
LID - e0171318
AB  - This study aimed to evaluate the influence of acute and chronic exercise on 
      erythrocyte membrane stability and various blood indices in a population 
      consisting of five national-level male swimmers, over 18 weeks of training. The 
      evaluations were made at the beginning and end of the 1st, 7th, 13th and 18th 
      weeks, when volume and training intensity have changed. The effects manifested at 
      the beginning of those weeks were considered due to chronic adaptations, while 
      the effects observed at the end of the weeks were considered due to acute 
      manifestations of the exercise load of that week. Acute changes resulting from 
      the exercise comprised increases in creatine kinase activity (CK) and leukocyte 
      count (Leu), and decrease in hematocrit (Ht) and mean corpuscular volume (MCV), 
      at the end of the first week; increase in the activities of CK and lactate 
      dehydrogenase (LDH), in the uric acid (UA) concentration and Leu count, at the 
      end of the seventh week; increases in CK and LDH activities and in the mean 
      corpuscular hemoglobin concentration (MCHC), at the end of the 13th week; and 
      decrease in the value of the osmotic stability index 1/H50 and increases in the 
      CK activity and platelets (Plt) count, at the end of the 18th week. Chronic 
      changes due to training comprised increase in the values of 1/H50, CK, LDH, 
      high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol 
      (LDL-C), serum iron (Fe), MCV and Plt. Although acute training has resulted in 
      decrease in the osmotic stability of erythrocytes, possibly associated with 
      exacerbation of the oxidative processes during intense exercise, chronic training 
      over 18 weeks resulted in increased osmotic stability of erythrocytes, possibly 
      by modulation in the membrane cholesterol content by low and high density 
      lipoproteins.
FAU - Paraiso, Lara Ferreira
AU  - Paraiso LF
AD  - Institute of Genetics and Biochemistry, Federal University of Uberlandia, 
      Uberlandia, Minas Gerais, Brazil.
FAU - Goncalves-E-Oliveira, Ana Flavia Mayrink
AU  - Goncalves-E-Oliveira AF
AD  - Institute of Genetics and Biochemistry, Federal University of Uberlandia, 
      Uberlandia, Minas Gerais, Brazil.
FAU - Cunha, Lucas Moreira
AU  - Cunha LM
AD  - Institute of Genetics and Biochemistry, Federal University of Uberlandia, 
      Uberlandia, Minas Gerais, Brazil.
FAU - de Almeida Neto, Omar Pereira
AU  - de Almeida Neto OP
AD  - Department of Health Sciences, Federal University of Goias, Jatai, Goias, Brazil.
FAU - Pacheco, Adriana Garcia
AU  - Pacheco AG
AD  - Institute of Genetics and Biochemistry, Federal University of Uberlandia, 
      Uberlandia, Minas Gerais, Brazil.
FAU - Araujo, Karinne Beatriz Goncalves
AU  - Araujo KB
AD  - Institute of Genetics and Biochemistry, Federal University of Uberlandia, 
      Uberlandia, Minas Gerais, Brazil.
FAU - Garrote-Filho, Mario da Silva
AU  - Garrote-Filho MD
AD  - Institute of Genetics and Biochemistry, Federal University of Uberlandia, 
      Uberlandia, Minas Gerais, Brazil.
FAU - Bernardino Neto, Morun
AU  - Bernardino Neto M
AD  - Department of Basic and Environmental Sciences, University of Sao Paulo, Lorena, 
      Sao Paulo, Brazil.
FAU - Penha-Silva, Nilson
AU  - Penha-Silva N
AUID- ORCID: 0000-0002-8205-6213
AD  - Institute of Genetics and Biochemistry, Federal University of Uberlandia, 
      Uberlandia, Minas Gerais, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20170202
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 268B43MJ25 (Uric Acid)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 2.7.3.2 (Creatine Kinase)
SB  - IM
MH  - Athletes
MH  - Creatine Kinase/blood
MH  - Erythrocyte Indices/physiology
MH  - Erythrocyte Membrane/*metabolism
MH  - Hematocrit
MH  - Humans
MH  - L-Lactate Dehydrogenase/blood
MH  - Leukocyte Count
MH  - Male
MH  - Osmotic Fragility/physiology
MH  - Platelet Count
MH  - Swimming/*physiology
MH  - Uric Acid/blood
MH  - Young Adult
PMC - PMC5289559
COIS- The authors have declared that no competing interests exist.
EDAT- 2017/02/06 06:00
MHDA- 2017/08/22 06:00
PMCR- 2017/02/02
CRDT- 2017/02/03 06:00
PHST- 2016/06/06 00:00 [received]
PHST- 2017/01/19 00:00 [accepted]
PHST- 2017/02/03 06:00 [entrez]
PHST- 2017/02/06 06:00 [pubmed]
PHST- 2017/08/22 06:00 [medline]
PHST- 2017/02/02 00:00 [pmc-release]
AID - PONE-D-16-22714 [pii]
AID - 10.1371/journal.pone.0171318 [doi]
PST - epublish
SO  - PLoS One. 2017 Feb 2;12(2):e0171318. doi: 10.1371/journal.pone.0171318. 
      eCollection 2017.