PMID- 28152237
OWN - NLM
STAT- MEDLINE
DCOM- 20180611
LR  - 20200306
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Print)
IS  - 1053-1807 (Linking)
VI  - 46
IP  - 4
DP  - 2017 Oct
TI  - Native T(1) value in the remote myocardium is independently associated with left 
      ventricular dysfunction in patients with prior myocardial infarction.
PG  - 1073-1081
LID - 10.1002/jmri.25652 [doi]
AB  - PURPOSE: To compare remote myocardium native T(1) in patients with chronic 
      myocardial infarction (MI) and controls without MI and to elucidate the 
      relationship of infarct size and native T(1) in the remote myocardium for the 
      prediction of left ventricular (LV) systolic dysfunction after MI. MATERIALS AND 
      METHODS: A total of 41 chronic MI (18 anterior MI) patients and 15 age-matched 
      volunteers with normal LV systolic function and no history of MI underwent 
      cardiac magnetic resonance imaging (MRI) at 1.5T. Native T(1) map was performed 
      using a slice interleaved T(1) mapping and late gadolinium enhancement (LGE) 
      imaging. Cine MR was acquired to assess LV function and mass. RESULTS: The remote 
      myocardium native T(1) time was significantly elevated in patients with prior MI, 
      compared to controls, for both anterior MI and nonanterior MI (anterior MI: 
      1099 +/- 30, nonanterior MI: 1097 +/- 39, controls: 1068 +/- 25 msec, P < 0.05). Remote 
      myocardium native T(1) moderately correlated with LV volume, mass index, and 
      ejection fraction (r = 0.38, 0.50, -0.49, respectively, all P < 0.05). LGE 
      infarct size had a moderate correlation with reduced LV ejection fraction 
      (r = -0.33, P < 0.05), but there was no significant association between native 
      T(1) and infarct size. Native T(1) time in the remote myocardium was 
      independently associated with reduced LV ejection fraction, after adjusting for 
      age, gender, infarct size, and comorbidity (beta = -0.34, P = 0.03). CONCLUSION: In 
      chronic MI, the severity of LV systolic dysfunction after MI is independently 
      associated with native T(1) in the remote myocardium. Diffuse myocardial fibrosis 
      in the remote myocardium may play an important pathophysiological role of post-MI 
      LV dysfunction. LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 2 J. Magn. Reson. 
      Imaging 2017;46:1073-1081.
CI  - (c) 2017 International Society for Magnetic Resonance in Medicine.
FAU - Nakamori, Shiro
AU  - Nakamori S
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center and Harvard Medical School, Boston, Massachusetts, USA.
FAU - Alakbarli, Javid
AU  - Alakbarli J
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center and Harvard Medical School, Boston, Massachusetts, USA.
FAU - Bellm, Steven
AU  - Bellm S
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center and Harvard Medical School, Boston, Massachusetts, USA.
FAU - Motiwala, Shweta R
AU  - Motiwala SR
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center and Harvard Medical School, Boston, Massachusetts, USA.
FAU - Addae, Gifty
AU  - Addae G
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center and Harvard Medical School, Boston, Massachusetts, USA.
FAU - Manning, Warren J
AU  - Manning WJ
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center and Harvard Medical School, Boston, Massachusetts, USA.
AD  - Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical 
      School, Boston, Massachusetts, USA.
FAU - Nezafat, Reza
AU  - Nezafat R
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center and Harvard Medical School, Boston, Massachusetts, USA.
LA  - eng
GR  - R01 EB008743/EB/NIBIB NIH HHS/United States
GR  - R01 HL129157/HL/NHLBI NIH HHS/United States
GR  - R01 HL129185/HL/NHLBI NIH HHS/United States
GR  - R21 HL127650/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20170202
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Heart/*diagnostic imaging
MH  - Heart Ventricles/diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/*physiopathology
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Time
MH  - Ventricular Dysfunction, Left/complications/*diagnostic imaging/*physiopathology
PMC - PMC5599253
MID - NIHMS845054
OTO - NOTNLM
OT  - diffuse myocardial fibrosis
OT  - left ventricular dysfunction
OT  - myocardial infarction
OT  - native T1 map
EDAT- 2017/02/06 06:00
MHDA- 2018/06/12 06:00
PMCR- 2018/10/01
CRDT- 2017/02/03 06:00
PHST- 2016/11/11 00:00 [received]
PHST- 2017/01/12 00:00 [accepted]
PHST- 2017/02/06 06:00 [pubmed]
PHST- 2018/06/12 06:00 [medline]
PHST- 2017/02/03 06:00 [entrez]
PHST- 2018/10/01 00:00 [pmc-release]
AID - 10.1002/jmri.25652 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2017 Oct;46(4):1073-1081. doi: 10.1002/jmri.25652. Epub 
      2017 Feb 2.