PMID- 28153537
OWN - NLM
STAT- MEDLINE
DCOM- 20171204
LR  - 20220317
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 232
DP  - 2017 Apr 1
TI  - Quantitative assessment of systolic and diastolic function in patients with LGE 
      negative systemic amyloidosis using CMR.
PG  - 336-341
LID - S0167-5273(16)34542-9 [pii]
LID - 10.1016/j.ijcard.2016.12.054 [doi]
AB  - OBJECTIVES: In clinical routine myocardial affection in amyloidosis is assessed 
      by qualitative late gadolinium enhancement (LGE). Recent studies suggest that 
      early cardiac involvement in amyloidosis may be overlooked by qualitative LGE 
      assessment. The aim of this study was to assess possible early cardiac 
      involvement in LGE negative AL patients by means of systolic and diastolic strain 
      assessment and quantitative enhancement. METHODS: 51 individuals (17 Patients 
      with LGE positive light-chain amyloidosis (AL) (Group A), 17 Patients with LGE 
      negative systemic AL (Group B), and 17 healthy controls (Group C)) were 
      investigated. SSFP-Cine sequences were acquired in short axis slices as well as 
      horizontal long axis views. Standard CMR parameters as well as Feature Tracking 
      (FT) derived systolic and diastolic circumferential and longitudinal strain 
      parameters were calculated. Additionally, contrast enhanced MRI images were 
      analyzed to quantitatively determine the extent of enhancement. RESULTS: AL 
      patients with and without LGE both had significantly lower early diastolic strain 
      rate (EDSR) values and peak systolic longitudinal strain (PSLS) values than 
      healthy controls (EDSR: Group A 63.1+/-17.6; Group B: 74.46+/-11.8; Group C: 
      86.82+/-12.7; F(2.48)=10.7 p<0.001); (PSLS: Group A: -13.44+/-1.9%; Group B: 
      -20.31+/-1.2%; Group C: -23.11+/-1.4%; F(2.48)=167.6; p<0.001). Analysis of 
      quantitative LGE enhancement revealed increased enhancement in qualitative LGE 
      negative AL patients compared to healthy controls (Group A: 19.6+/-8.9%; Group B: 
      8.2+/-3.9%; Group C: 2.4+/-1.3% F(2.48)=52.2; p<0.001). CONCLUSION: CMR strain 
      analysis detects early systolic and diastolic strain impairment in AL patients 
      lacking qualitative LGE enhancement.
CI  - Copyright A(c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Kuetting, Daniel L R
AU  - Kuetting DL
AD  - Department of Radiology, University of Bonn, Sigmund-Freud-Str.25, 53127 Bonn, 
      Germany. Electronic address: daniel.kuetting@ukb.uni-bonn.de.
FAU - Homsi, Rami
AU  - Homsi R
AD  - Department of Radiology, University of Bonn, Sigmund-Freud-Str.25, 53127 Bonn, 
      Germany. Electronic address: rami.homsi@ukb.uni-bonn.de.
FAU - Sprinkart, Alois M
AU  - Sprinkart AM
AD  - Department of Radiology, University of Bonn, Sigmund-Freud-Str.25, 53127 Bonn, 
      Germany. Electronic address: Alois_.sprinkart@ukb.uni-bonn.de.
FAU - Luetkens, Julian
AU  - Luetkens J
AD  - Department of Radiology, University of Bonn, Sigmund-Freud-Str.25, 53127 Bonn, 
      Germany. Electronic address: julian.luetkens@ukb.uni-bonn.de.
FAU - Thomas, Daniel K
AU  - Thomas DK
AD  - Department of Radiology, University of Bonn, Sigmund-Freud-Str.25, 53127 Bonn, 
      Germany. Electronic address: daniel.thomas@ukb.uni-bonn.de.
FAU - Schild, Hans H
AU  - Schild HH
AD  - Department of Radiology, University of Bonn, Sigmund-Freud-Str.25, 53127 Bonn, 
      Germany. Electronic address: hans.schild@ukb.uni-bonn.de.
FAU - Dabir, Darius
AU  - Dabir D
AD  - Department of Radiology, University of Bonn, Sigmund-Freud-Str.25, 53127 Bonn, 
      Germany. Electronic address: darius.dabir@ukb.uni-bonn.de.
LA  - eng
PT  - Journal Article
DEP - 20161222
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
CIN - Int J Cardiol. 2017 Nov 15;247:45. PMID: 28916083
CIN - Int J Cardiol. 2018 Apr 1;256:22. PMID: 29397204
MH  - Aged
MH  - Algorithms
MH  - Amyloidosis/complications/*diagnosis
MH  - Cardiomyopathies/*diagnosis/etiology/physiopathology
MH  - Contrast Media/pharmacology
MH  - Diastole
MH  - Female
MH  - Heart Ventricles/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Organometallic Compounds/*pharmacology
MH  - Reproducibility of Results
MH  - Systole
MH  - Ventricular Function, Left/*physiology
OTO - NOTNLM
OT  - Amyloidosis
OT  - CMR
OT  - Quantitative enhancement
OT  - Strain analysis
EDAT- 2017/02/06 06:00
MHDA- 2017/12/05 06:00
CRDT- 2017/02/04 06:00
PHST- 2016/06/24 00:00 [received]
PHST- 2016/11/11 00:00 [revised]
PHST- 2016/12/16 00:00 [accepted]
PHST- 2017/02/06 06:00 [pubmed]
PHST- 2017/12/05 06:00 [medline]
PHST- 2017/02/04 06:00 [entrez]
AID - S0167-5273(16)34542-9 [pii]
AID - 10.1016/j.ijcard.2016.12.054 [doi]
PST - ppublish
SO  - Int J Cardiol. 2017 Apr 1;232:336-341. doi: 10.1016/j.ijcard.2016.12.054. Epub 
      2016 Dec 22.