PMID- 28157226
OWN - NLM
STAT- MEDLINE
DCOM- 20181024
LR  - 20220311
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
DP  - 2017 Feb 3
TI  - Early exposure to thirdhand cigarette smoke affects body mass and the development 
      of immunity in mice.
PG  - 41915
LID - 10.1038/srep41915 [doi]
LID - 41915
AB  - Thirdhand smoke (THS) is the fraction of cigarette smoke that persists in indoor 
      environments after smoking. We investigated the effects of neonatal and adult THS 
      exposure on bodyweight and blood cell populations in C57BL/6 J mice. At the end 
      of neonatal exposure, THS-treated male and female mice had significantly lower 
      bodyweight than their respective control mice. However, five weeks after neonatal 
      exposure ended, THS-treated mice weighed the same as controls. In contrast, adult 
      THS exposure did not change bodyweight of mice. On the other hand, both neonatal 
      and adult THS exposure had profound effects on the hematopoietic system. Fourteen 
      weeks after neonatal THS exposure ended, eosinophil number and platelet volume 
      were significantly higher, while hematocrit, mean cell volume, and platelet 
      counts were significantly lower compared to control. Similarly, adult THS 
      exposure also decreased platelet counts and increased neutrophil counts. 
      Moreover, both neonatal and adult THS exposure caused a significant increase in 
      percentage of B-cells and significantly decreased percentage of myeloid cells. 
      Our results demonstrate that neonatal THS exposure decreases bodyweight and that 
      THS exposure induces persistent changes in the hematopoietic system independent 
      of age at exposure. These results also suggest that THS exposure may have adverse 
      effects on human health.
FAU - Hang, Bo
AU  - Hang B
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, USA.
FAU - Snijders, Antoine M
AU  - Snijders AM
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, USA.
FAU - Huang, Yurong
AU  - Huang Y
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, USA.
FAU - Schick, Suzaynn F
AU  - Schick SF
AD  - Department of Medicine, Division of Occupational and Environmental Medicine, 
      University of California, San Francisco, Box 0843, San Francisco, CA 94143, USA.
FAU - Wang, Pin
AU  - Wang P
AD  - Department of Gastroenterology, The Affiliated Drum Tower, Clinical Medical 
      School, Nanjing Medical University, Nanjing, Jiangsu 210008, China.
FAU - Xia, Yankai
AU  - Xia Y
AD  - State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing 
      Medical University, Nanjing 211166, China.
FAU - Havel, Christopher
AU  - Havel C
AD  - Department of Medicine, Division of Occupational and Environmental Medicine, 
      University of California, San Francisco, Box 0843, San Francisco, CA 94143, USA.
FAU - Jacob, Peyton 3rd
AU  - Jacob P 3rd
AD  - Department of Medicine, Division of Occupational and Environmental Medicine, 
      University of California, San Francisco, Box 0843, San Francisco, CA 94143, USA.
FAU - Benowitz, Neal
AU  - Benowitz N
AD  - Department of Medicine, Division of Occupational and Environmental Medicine, 
      University of California, San Francisco, Box 0843, San Francisco, CA 94143, USA.
FAU - Destaillats, Hugo
AU  - Destaillats H
AD  - Indoor Environment Group, Lawrence Berkeley National Laboratory, Berkeley, CA 
      94720, USA.
FAU - Gundel, Lara A
AU  - Gundel LA
AD  - Indoor Environment Group, Lawrence Berkeley National Laboratory, Berkeley, CA 
      94720, USA.
FAU - Mao, Jian-Hua
AU  - Mao JH
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, USA.
LA  - eng
GR  - P30 DA012393/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20170203
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Tobacco Smoke Pollution)
SB  - IM
MH  - Animals
MH  - Blood Cell Count
MH  - *Body Weight
MH  - Female
MH  - *Hematopoiesis
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Tobacco Smoke Pollution/*adverse effects
PMC - PMC5291208
COIS- The authors declare no competing financial interests.
EDAT- 2017/02/06 06:00
MHDA- 2018/10/26 06:00
PMCR- 2017/02/03
CRDT- 2017/02/04 06:00
PHST- 2016/04/20 00:00 [received]
PHST- 2017/01/04 00:00 [accepted]
PHST- 2017/02/04 06:00 [entrez]
PHST- 2017/02/06 06:00 [pubmed]
PHST- 2018/10/26 06:00 [medline]
PHST- 2017/02/03 00:00 [pmc-release]
AID - srep41915 [pii]
AID - 10.1038/srep41915 [doi]
PST - epublish
SO  - Sci Rep. 2017 Feb 3;7:41915. doi: 10.1038/srep41915.