PMID- 28160247
OWN - NLM
STAT- MEDLINE
DCOM- 20170320
LR  - 20181113
IS  - 1865-7265 (Electronic)
IS  - 1865-7265 (Linking)
VI  - 10
IP  - 2
DP  - 2017 Apr
TI  - Adenocarcinoma arising in multiple hyperplastic polyps in a patient with 
      Helicobacter pylori infection and hypergastrinemia during long-term proton pump 
      inhibitor therapy.
PG  - 128-136
LID - 10.1007/s12328-017-0714-7 [doi]
AB  - We report a case of developing multiple adenocarcinoma foci in multiple 
      hyperplastic polyps in a patient with Helicobacter pylori infection and 
      hypergastrinemia during long-term proton pump inhibitor (PPI) therapy. A 
      57-year-old man, who was undergoing hemodialysis for chronic renal failure, 
      underwent an upper gastrointestinal endoscopy to elucidate the cause of anemia. 
      Atrophic gastritis with H. pylori infection and multiple adenocarcinoma foci in 
      multiple hyperplastic polyps were found in the endoscopic and histological 
      examinations. Enterochromaffin-like micronests and parietal cell protrusion in 
      the background of the polyps suggested the existence of hypergastrinemia. The 
      serum gastrin level was markedly high-10,206 pg/ml (normal range 37-172 pg/ml). 
      The cause of this marked hypergastrinemia was not autoimmune gastritis and 
      gastrinoma. After discontinuing PPI therapy and successful eradication of H. 
      pylori, the serum gastrin level decreased to normal range. These findings 
      indicate that hypergastrinemia may be caused by long-term PPI therapy in patients 
      with H. pylori infection. This case suggests that hypergastrinemia may mediate 
      gastric carcinogenesis in patients with H. pylori infection.
FAU - Anjiki, Hajime
AU  - Anjiki H
AUID- ORCID: 0000-0001-7157-5352
AD  - Department of Gastroenterology, Toyosato Hospital, 12 Hachime, Toyosato-cho, 
      Inukami-gun, Shiga, 529-1168, Japan. ananjikijiki@bell.ocn.ne.jp.
FAU - Mukaisho, Ken-Ichi
AU  - Mukaisho KI
AD  - Department of Pathology, Division of Molecular Diagnostic Pathology, Shiga 
      University of Medical Science, Otsu, Japan.
FAU - Kadomoto, Yu
AU  - Kadomoto Y
AD  - Department of Gastroenterology, Toyosato Hospital, 12 Hachime, Toyosato-cho, 
      Inukami-gun, Shiga, 529-1168, Japan.
FAU - Doi, Hisakazu
AU  - Doi H
AD  - Department of Gastroenterology, Toyosato Hospital, 12 Hachime, Toyosato-cho, 
      Inukami-gun, Shiga, 529-1168, Japan.
FAU - Yoshikawa, Kunio
AU  - Yoshikawa K
AD  - Department of Gastroenterology, Toyosato Hospital, 12 Hachime, Toyosato-cho, 
      Inukami-gun, Shiga, 529-1168, Japan.
FAU - Nakayama, Takahisa
AU  - Nakayama T
AD  - Department of Pathology, Division of Molecular Diagnostic Pathology, Shiga 
      University of Medical Science, Otsu, Japan.
FAU - Vo, Diem Thi-Ngoc
AU  - Vo DT
AD  - Department of Pathology, University of Medicine and Pharmacy, Ho Chi Minh City, 
      Vietnam.
FAU - Hattori, Takanori
AU  - Hattori T
AD  - Department of Pathology, Division of Molecular Diagnostic Pathology, Shiga 
      University of Medical Science, Otsu, Japan.
FAU - Sugihara, Hiroyuki
AU  - Sugihara H
AD  - Department of Pathology, Division of Molecular Diagnostic Pathology, Shiga 
      University of Medical Science, Otsu, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170203
PL  - Japan
TA  - Clin J Gastroenterol
JT  - Clinical journal of gastroenterology
JID - 101477246
RN  - 0 (Gastrins)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adenocarcinoma/*etiology
MH  - Cocarcinogenesis
MH  - Drug Administration Schedule
MH  - Gastrins/blood
MH  - Gastritis, Atrophic/complications
MH  - Gastroscopy
MH  - Helicobacter Infections/*complications
MH  - *Helicobacter pylori
MH  - Humans
MH  - Hyperplasia
MH  - Male
MH  - Middle Aged
MH  - Polyps/diagnosis/etiology
MH  - Proton Pump Inhibitors/administration & dosage/*adverse effects
MH  - Stomach Neoplasms/diagnosis/*etiology
OTO - NOTNLM
OT  - Gastric adenocarcinoma
OT  - H. pylori infection
OT  - Hypergastrinemia
OT  - Proton pump inhibitor therapy
EDAT- 2017/02/06 06:00
MHDA- 2017/03/21 06:00
CRDT- 2017/02/05 06:00
PHST- 2016/07/23 00:00 [received]
PHST- 2017/01/17 00:00 [accepted]
PHST- 2017/02/06 06:00 [pubmed]
PHST- 2017/03/21 06:00 [medline]
PHST- 2017/02/05 06:00 [entrez]
AID - 10.1007/s12328-017-0714-7 [pii]
AID - 10.1007/s12328-017-0714-7 [doi]
PST - ppublish
SO  - Clin J Gastroenterol. 2017 Apr;10(2):128-136. doi: 10.1007/s12328-017-0714-7. 
      Epub 2017 Feb 3.