PMID- 28161701
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20220410
IS  - 1423-0208 (Electronic)
IS  - 0251-5350 (Linking)
VI  - 48
IP  - 1-2
DP  - 2017
TI  - Changes in Quality of Life in Parkinson's Disease: How Large Must They Be to Be 
      Relevant?
PG  - 1-8
LID - 10.1159/000455863 [doi]
AB  - BACKGROUND: Minimal clinically important difference (MCID) is the smallest change 
      in an outcome, which a patient identifies as meaningful. Although the 2 most 
      frequently applied Parkinson's disease (PD) "quality of life" questionnaires (the 
      PDQ-39 and PDQ-8) provide encouragingly similar results, their MCID thresholds 
      appear to be vastly different. Our aim was to calculate the MCID estimates for 
      both PDQ-39 and PDQ-8 Summary Indices (PDQ-39-SI and PDQ-8-SI) by the utilization 
      of both anchor- and distribution-based techniques. METHODS: Nine hundred 
      eighty-five paired investigations of 365 patients were included. Three different 
      techniques were used simultaneously to calculate the MCID values. RESULTS: First, 
      we replicated the previously published results demonstrating how both PDQ-39-SI 
      and PDQ-8-SI provide similar values and respond in a similar way to changes. 
      Subsequently, we calculated the MCID thresholds. The most optimal estimates for 
      MCID thresholds for PDQ-39-SI were -4.72 and +4.22 for detecting minimal 
      clinically important improvement and worsening. For PDQ-8-SI, these estimates 
      were -5.94 and +4.91 points for detecting minimal clinically important 
      improvement and worsening respectively. CONCLUSIONS: Our study is the first one 
      that directly compared the MCID estimates for both PDQ-39-SI and PDQ-8-SI on a 
      large pool of patients including all disease severity stages. These MICD 
      estimates varied across PD severity.
CI  - (c) 2017 S. Karger AG, Basel.
FAU - Horvath, Krisztina
AU  - Horvath K
AD  - Doctoral School of Clinical Neuroscience, University of Pecs, Pecs, Hungary.
FAU - Aschermann, Zsuzsanna
AU  - Aschermann Z
FAU - Kovacs, Marton
AU  - Kovacs M
FAU - Makkos, Attila
AU  - Makkos A
FAU - Harmat, Mark
AU  - Harmat M
FAU - Janszky, Jozsef
AU  - Janszky J
FAU - Komoly, Samuel
AU  - Komoly S
FAU - Karadi, Kazmer
AU  - Karadi K
FAU - Kovacs, Norbert
AU  - Kovacs N
LA  - eng
PT  - Journal Article
DEP - 20170204
PL  - Switzerland
TA  - Neuroepidemiology
JT  - Neuroepidemiology
JID - 8218700
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Minimal Clinically Important Difference
MH  - Parkinson Disease/diagnosis/*psychology
MH  - *Quality of Life
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - Minimal clinically important change
OT  - Minimal clinically important difference
OT  - Parkinson's disease
OT  - Patient reported outcomes
OT  - Receiver operating characteristic curve
EDAT- 2017/02/06 06:00
MHDA- 2018/03/27 06:00
CRDT- 2017/02/06 06:00
PHST- 2016/11/25 00:00 [received]
PHST- 2017/01/03 00:00 [accepted]
PHST- 2017/02/06 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2017/02/06 06:00 [entrez]
AID - 000455863 [pii]
AID - 10.1159/000455863 [doi]
PST - ppublish
SO  - Neuroepidemiology. 2017;48(1-2):1-8. doi: 10.1159/000455863. Epub 2017 Feb 4.