PMID- 28161798
OWN - NLM
STAT- MEDLINE
DCOM- 20180101
LR  - 20200204
IS  - 1438-2199 (Electronic)
IS  - 0939-4451 (Print)
IS  - 0939-4451 (Linking)
VI  - 49
IP  - 5
DP  - 2017 May
TI  - Behavioral and inflammatory response in animals exposed to a low-pressure blast 
      wave and supplemented with beta-alanine.
PG  - 871-886
LID - 10.1007/s00726-017-2383-8 [doi]
AB  - This study investigated the benefit of beta-alanine (BA) supplementation on 
      behavioral and cognitive responses relating to mild traumatic brain injury (mTBI) 
      and post-traumatic stress disorder (PTSD) in rats exposed to a low-pressure blast 
      wave. Animals were fed a normal diet with or without (PL) BA supplementation 
      (100 mg kg(-1)) for 30-day, prior to being exposed to a low-pressure blast wave. 
      A third group of animals served as a control (CTL). These animals were fed a 
      normal diet, but were not exposed to the blast. Validated cognitive-behavioral 
      paradigms were used to assess both mTBI and PTSD-like behavior on days 7-14 
      following the blast. Brain-derived neurotrophic factor (BDNF), neuropeptide Y, 
      glial fibrillary acidic protein (GFAP) and tau protein expressions were analyzed 
      a day later. In addition, brain carnosine and histidine content was assessed as 
      well. The prevalence of animals exhibiting mTBI-like behavior was significantly 
      lower (p = 0.044) in BA than PL (26.5 and 46%, respectively), but no difference 
      (p = 0.930) was noted in PTSD-like behavior between the groups (10.2 and 12.0%, 
      respectively). Carnosine content in the cerebral cortex was higher (p = 0.048) 
      for BA compared to PL, while a trend towards a difference was seen in the 
      hippocampus (p = 0.058) and amygdala (p = 0.061). BDNF expression in the CA1 
      subregion of PL was lower than BA (p = 0.009) and CTL (p < 0.001), while GFAP 
      expression in CA1 (p = 0.003) and CA3 (p = 0.040) subregions were higher in PL 
      than other groups. Results indicated that BA supplementation for 30-day increased 
      resiliency to mTBI in animals exposed to a low-pressure blast wave.
FAU - Hoffman, Jay R
AU  - Hoffman JR
AD  - Institute of Exercise Physiology and Wellness, Sport and Exercise Science, 
      Burnett School of Biomedical Sciences, University of Central Florida, Orlando, 
      FL, 32816, USA. jay.hoffman@ucf.edu.
FAU - Zuckerman, Amitai
AU  - Zuckerman A
AD  - Division of Psychiatry, Anxiety and Stress Research Unit, Faculty of Health 
      Sciences, Beer-Sheva Mental Health Center, Ben-Gurion University of the Negev, 
      Beer-Sheva, Israel.
FAU - Ram, Omri
AU  - Ram O
AD  - Department of Mechanical Engineering, Ben-Gurion University, Beer-Sheva, Israel.
FAU - Sadot, Oren
AU  - Sadot O
AD  - Department of Mechanical Engineering, Ben-Gurion University, Beer-Sheva, Israel.
FAU - Stout, Jeffrey R
AU  - Stout JR
AD  - Institute of Exercise Physiology and Wellness, Sport and Exercise Science, 
      Burnett School of Biomedical Sciences, University of Central Florida, Orlando, 
      FL, 32816, USA.
FAU - Ostfeld, Ishay
AU  - Ostfeld I
AD  - Israel Defense Forces, Medical Corps, Tel Aviv, Israel.
FAU - Cohen, Hagit
AU  - Cohen H
AD  - Division of Psychiatry, Anxiety and Stress Research Unit, Faculty of Health 
      Sciences, Beer-Sheva Mental Health Center, Ben-Gurion University of the Negev, 
      Beer-Sheva, Israel.
LA  - eng
PT  - Journal Article
DEP - 20170204
PL  - Austria
TA  - Amino Acids
JT  - Amino acids
JID - 9200312
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (GFAP protein, rat)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Mapt protein, rat)
RN  - 0 (Neuropeptide Y)
RN  - 0 (tau Proteins)
RN  - 11P2JDE17B (beta-Alanine)
RN  - 4QD397987E (Histidine)
RN  - 8HO6PVN24W (Carnosine)
SB  - IM
MH  - Animals
MH  - Blast Injuries/genetics/*metabolism/physiopathology
MH  - Brain Chemistry
MH  - Brain Injuries/genetics/*metabolism/physiopathology
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Carnosine/metabolism
MH  - *Dietary Supplements
MH  - Gene Expression
MH  - Glial Fibrillary Acidic Protein/genetics/metabolism
MH  - Histidine/metabolism
MH  - Male
MH  - Neuropeptide Y/genetics/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stress Disorders, Post-Traumatic/genetics/*metabolism/physiopathology/*prevention 
      & control
MH  - beta-Alanine/*administration & dosage
MH  - tau Proteins/genetics/metabolism
PMC - PMC5383715
OTO - NOTNLM
OT  - BDNF
OT  - Carnosine
OT  - GFAP
OT  - Mild traumatic brain injury
OT  - Supplementation
COIS- CONFLICT OF INTEREST: All authors declare that no competing financial interests 
      exist. ETHICAL APPROVAL: This study was performed according to the principles and 
      guidelines of the National Institute of Health Guide for the Care and Use of 
      Laboratory Animals. All treatment and testing procedures were approved by the 
      Animal Care Committee of the Ben-Gurion University of the Negev, Israel.
EDAT- 2017/02/06 06:00
MHDA- 2018/01/02 06:00
PMCR- 2017/02/04
CRDT- 2017/02/06 06:00
PHST- 2016/12/21 00:00 [received]
PHST- 2017/01/18 00:00 [accepted]
PHST- 2017/02/06 06:00 [pubmed]
PHST- 2018/01/02 06:00 [medline]
PHST- 2017/02/06 06:00 [entrez]
PHST- 2017/02/04 00:00 [pmc-release]
AID - 10.1007/s00726-017-2383-8 [pii]
AID - 2383 [pii]
AID - 10.1007/s00726-017-2383-8 [doi]
PST - ppublish
SO  - Amino Acids. 2017 May;49(5):871-886. doi: 10.1007/s00726-017-2383-8. Epub 2017 
      Feb 4.