PMID- 28163282
OWN - NLM
STAT- MEDLINE
DCOM- 20171010
LR  - 20190211
IS  - 1348-9585 (Electronic)
IS  - 1341-9145 (Print)
IS  - 1341-9145 (Linking)
VI  - 59
IP  - 3
DP  - 2017 May 25
TI  - Potential objective biomarkers for fatigue among working women.
PG  - 286-291
LID - 10.1539/joh.16-0206-BR [doi]
AB  - OBJECTIVE: The prediction of health impairment due to work overload is 
      subjectively assessed based on recognized symptoms; however, objective evaluation 
      is primarily ideal in the field of occupational health. Recently, some biomarkers 
      of autonomic function and/or oxidative stress were reported to be associated with 
      fatigue. This study aimed to preliminarily investigate whether these biomarkers 
      could be objective indicators for fatigue and stress among working women. METHOD: 
      Participants included 118 full-time female workers (mean age 37.8 years), 
      including 55 shift workers. Self-administered questionnaires, such as visual 
      analog scale (VAS) for general health, a lifestyle questionnaire, SF-8 for 
      health-related quality of life, and K6 for mental health screening, were used. In 
      addition, biomarkers such as acceleration plethysmogram (APG), reactive oxygen 
      metabolites-derived compounds (d-ROMs), and biological antioxidant potential 
      (BAP) were measured. RESULTS: A significant association was observed between BAP 
      and VAS (r=0.482, p<0.01) among shift workers. However, other biomarkers such as 
      APG and d-ROMs were not significantly associated with symptoms. d-ROMs were 
      significantly correlated with age and body mass index. There was a significant 
      negative correlation between BAP and smoking. Results of the APG (low-frequency 
      (LF) /high-frequency (HF) ratio) were significantly correlated with BAP, but not 
      with d-ROMs. The LF/HF ratio and BAP for shift workers were significantly higher 
      than those for day-time workers. CONCLUSIONS: Our results suggest that APG and 
      BAP are potential objective biomarkers for fatigue among working women, although 
      further follow-up studies are needed to clarify the scope of usefulness of the 
      biomarkers for fatigue.
FAU - Ebata, Chie
AU  - Ebata C
AD  - Wakayama-Rosai Hospital.
AD  - Ebata Occupational Health Research Institute.
FAU - Tatsuta, Hitomi
AU  - Tatsuta H
AD  - Wakayama-Rosai Hospital.
FAU - Tatemichi, Masayuki
AU  - Tatemichi M
AD  - Department of Preventive Medicine, Tokai University, School of Medicine.
LA  - eng
PT  - Journal Article
DEP - 20170204
PL  - Australia
TA  - J Occup Health
JT  - Journal of occupational health
JID - 9616320
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Antioxidants/*analysis
MH  - Biomarkers/*analysis
MH  - Body Mass Index
MH  - Fatigue/*physiopathology
MH  - Female
MH  - Humans
MH  - Japan
MH  - Middle Aged
MH  - Plethysmography
MH  - Risk Factors
MH  - Smoking
MH  - Stress, Psychological/physiopathology
MH  - Surveys and Questionnaires
MH  - *Women, Working
MH  - Work Schedule Tolerance/*physiology
PMC - PMC5478511
OTO - NOTNLM
OT  - Fatigue
OT  - Objective marker
OT  - Stress
OT  - Women workers
COIS- Conflicts of interest: The authors declare no conflict of interest.
EDAT- 2017/02/07 06:00
MHDA- 2017/10/11 06:00
PMCR- 2017/05/20
CRDT- 2017/02/07 06:00
PHST- 2017/02/07 06:00 [pubmed]
PHST- 2017/10/11 06:00 [medline]
PHST- 2017/02/07 06:00 [entrez]
PHST- 2017/05/20 00:00 [pmc-release]
AID - 10.1539/joh.16-0206-BR [doi]
PST - ppublish
SO  - J Occup Health. 2017 May 25;59(3):286-291. doi: 10.1539/joh.16-0206-BR. Epub 2017 
      Feb 4.