PMID- 28164544
OWN - NLM
STAT- MEDLINE
DCOM- 20171212
LR  - 20181023
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 62
IP  - 12
DP  - 2016 Dec 1
TI  - Clinical Significance of Red Blood Cell Distribution Width and Inflammatory 
      Factors for the Disease Activity in Rheumatoid Arthritis.
PG  - 2327-2331
LID - 10.7754/Clin.Lab.2016.160406 [doi]
AB  - BACKGROUND: To evaluate the significance of red blood cell distribution width 
      (RDW) and other factors for the disease activity in rheumatoid arthritis (RA). 
      METHODS: Each patient underwent clinical examination and blood sampling for 
      assessment of serum high-sensitivity C-reactive protein (hs-CRP) levels, 
      erythrocyte sedimentation rate (ESR), hemoglobin concentration (Hb), hematocrit 
      (HCT), RDW, and other erythrocyte parameters (mean corpuscular volume [MCV], mean 
      cell Hb [MCH], mean corpuscular Hb concentration [MCHC]). Rheumatoid factors 
      (RF-IgA, -IgG, -IgM) and anti-cyclic citrullinated protein antibodies (anti-CCP) 
      were purified from the plasma and detected by ELISA. RA patients were divided 
      into two groups based on DAS28 scores: active RA group (DAS28 > 5.1) and inactive 
      RA group (DAS28 2.6 - 3.2). RESULTS: Patient samples were within normal ranges 
      for Hb (15.2 +/- 1.3 g/L), HCT (29.9 +/- 2.2%), and other red blood cell (RBC) 
      parameters (MCV 80.3 +/- 12.1 fL, MCH 26.6 +/- 3.5 pg, MCHC 323 +/- 25 g/L). The RDW 
      was higher in the active RA group than in the inactive group (16.5 +/- 3.2 vs. 13.9 
      +/- 1.5%, p < 0.01). Similarly, the proportion of patients positive for RF and 
      anti-CCP was higher in the active group than in the inactive group (RF 62 vs. 
      53%, CCP 83 vs. 61%). RF and anti-CCP were present at higher titers in patients 
      with active RA. The bone erosion rate in the 110 RA patients was 67%. Patients 
      with erosion had higher RDW than those without erosion (17.1 +/- 2.2 vs. 13.9 +/- 
      3.5%). High titers of anti-CCP and RF-IgM, -IgG, and -IgA were also associated 
      with high bone erosion rates (67%, 77%, 67%, and 73%, respectively). CONCLUSIONS: 
      Our results suggest an association between RDW and levels of inflammatory factors 
      and autoantibodies in RA. This association may be linked to the underlying 
      proinflammatory state and increased oxidative stress, both of which correlate 
      with impaired erythrocyte maturation. RDW, RF, and anti-CCP are key players in 
      the proinflammatory and proatherogenic status of RA, and they may represent 
      useful markers to improve characterization of disease activity in RA patients, 
      thereby helping the clinician to define more appropriate therapeutic strategies.
FAU - Yunchun, Li
AU  - Yunchun L
FAU - Yue, Wang
AU  - Yue W
FAU - Jun, Fang Z
AU  - Jun FZ
FAU - Qizhu, Su
AU  - Qizhu S
FAU - Liumei, Ding
AU  - Liumei D
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/*blood/diagnosis/immunology
MH  - Autoantibodies/*blood
MH  - Biomarkers/blood
MH  - Blood Sedimentation
MH  - Case-Control Studies
MH  - *Erythrocyte Indices
MH  - Female
MH  - Foot Bones/diagnostic imaging
MH  - Hand Bones/diagnostic imaging
MH  - Health Status
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2017/02/07 06:00
MHDA- 2017/12/13 06:00
CRDT- 2017/02/07 06:00
PHST- 2017/02/07 06:00 [entrez]
PHST- 2017/02/07 06:00 [pubmed]
PHST- 2017/12/13 06:00 [medline]
AID - 10.7754/Clin.Lab.2016.160406 [doi]
PST - ppublish
SO  - Clin Lab. 2016 Dec 1;62(12):2327-2331. doi: 10.7754/Clin.Lab.2016.160406.