PMID- 28164633
OWN - NLM
STAT- MEDLINE
DCOM- 20181002
LR  - 20190318
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 62
IP  - 7
DP  - 2016 Jul 1
TI  - Resistant Effect of HLA-DRB1*09 on Hepatitis C Virus Infection Identified by a 
      New Cross-Validation Method.
PG  - 1367-1370
LID - 10.7754/Clin.Lab.2015.151107 [doi]
AB  - BACKGROUND: The association of human leukocyte antigen (HLA) with HCV persistence 
      or clearance has not been clarified. We aim to investigate the associations of 
      HLA with HCV infection based on a new cross-validation method. METHODS: DNA 
      samples from HCV infected patients were collected at random. Sequence based 
      typing (PCR-SBT) was used to detect HLA-A, -B, -DRB1 alleles. The albumin (ALB) 
      levels were detected and compared between the patients carrying the gene and the 
      patients not carrying the gene. The association between the HLA loci and disease 
      status was further confirmed by cross-validation of the two sets of analytical 
      results. RESULTS: HLA-B*58 and HLA-DRB1*09 showed significant differences in ALB 
      levels between patients with and without the allele (p < 0.05). Only the p-value 
      of the cross-validation for HLA-DRB1*09 was less than 0.05. CONCLUSIONS: 
      HLA-DRB1*09 has a resistant effect on HCV infection, which is potentially helpful 
      to predict the status of HCV infected patients.
FAU - Wang, Zhen
AU  - Wang Z
FAU - Yang, Dong
AU  - Yang D
FAU - Cai, Meng
AU  - Cai M
FAU - Liu, Hui
AU  - Liu H
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Serum Albumin)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Female
MH  - HLA-A Antigens/blood/*genetics
MH  - HLA-B Antigens/blood/*genetics
MH  - HLA-DRB1 Chains/blood/*genetics
MH  - Hepacivirus/*immunology
MH  - Hepatitis C/blood/*immunology
MH  - Humans
MH  - Male
MH  - Polymerase Chain Reaction/methods
MH  - Serum Albumin/*analysis
EDAT- 2017/02/07 06:00
MHDA- 2018/10/03 06:00
CRDT- 2017/02/07 06:00
PHST- 2017/02/07 06:00 [entrez]
PHST- 2017/02/07 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
AID - 10.7754/Clin.Lab.2015.151107 [doi]
PST - ppublish
SO  - Clin Lab. 2016 Jul 1;62(7):1367-1370. doi: 10.7754/Clin.Lab.2015.151107.