PMID- 28166118
OWN - NLM
STAT- MEDLINE
DCOM- 20171208
LR  - 20220410
IS  - 1530-0315 (Electronic)
IS  - 0195-9131 (Print)
IS  - 0195-9131 (Linking)
VI  - 49
IP  - 7
DP  - 2017 Jul
TI  - All-Extremity Exercise Training Improves Arterial Stiffness in Older Adults.
PG  - 1404-1411
LID - 10.1249/MSS.0000000000001229 [doi]
AB  - Large elastic arteries stiffen with age, which predisposes older adults to 
      increased risk for cardiovascular disease. Aerobic exercise training is known to 
      reduce the risk for cardiovascular disease, but the optimal exercise prescription 
      for attenuating large elastic arterial stiffening in older adults is not known. 
      PURPOSE: The purpose of this randomized controlled trial was to compare the 
      effect of all-extremity high-intensity interval training (HIIT) and 
      moderate-intensity continuous training (MICT) on aortic pulse wave velocity (PWV) 
      and carotid artery compliance in older adults. METHODS: Forty-nine sedentary 
      older adults (age = 64 +/- 1 yr), free of overt major clinical disease, were 
      randomized to HIIT (n = 17), MICT (n = 18), or nonexercise controls (CONT; n = 
      14). HIIT (4 x 4 min at 90% HRpeak interspersed with 3 x 3 min active recovery at 
      70% HRpeak) and isocaloric MICT (70% HRpeak) were performed on an all-extremity 
      non-weight-bearing ergometer, 4 d.wk for 8 wk under supervision. Aortic (carotid 
      to femoral PWV [cfPWV]) and common carotid artery compliance were assessed at 
      pre- and postintervention. RESULTS: cfPWV improved by 0.5 m.s in MICT (P = 0.04) 
      but did not significantly change in HIIT and CONT (P > 0.05). Carotid artery 
      compliance improved by 0.03 mm.mm Hg in MICT (P = 0.001), but it remained 
      unchanged in HIIT and CONT (P > 0.05). Improvements in arterial stiffness in 
      response to MICT were not confounded by changes in aortic or brachial blood 
      pressure, HR, body weight, total and abdominal adiposity, blood lipids, or 
      aerobic fitness. CONCLUSION: All-extremity MICT, but not HIIT, improved central 
      arterial stiffness in previously sedentary older adults free of major clinical 
      disease. Our findings have important implications for aerobic exercise 
      prescription in older adults.
FAU - Kim, Han-Kyul
AU  - Kim HK
AD  - 1Department of Applied Physiology and Kinesiology, University of Florida, 
      Gainesville, FL; 2Division of Health and Exercise Science, Incheon National 
      University, Incheon, KOREA; and 3Division of Cardiovascular Medicine, University 
      of Florida, Gainesville, FL.
FAU - Hwang, Chueh-Lung
AU  - Hwang CL
FAU - Yoo, Jeung-Ki
AU  - Yoo JK
FAU - Hwang, Moon-Hyon
AU  - Hwang MH
FAU - Handberg, Eileen M
AU  - Handberg EM
FAU - Petersen, John W
AU  - Petersen JW
FAU - Nichols, Wilmer W
AU  - Nichols WW
FAU - Sofianos, Sofia
AU  - Sofianos S
FAU - Christou, Demetra D
AU  - Christou DD
LA  - eng
GR  - R21 AG050203/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
RN  - 0 (Lipids)
SB  - IM
MH  - Aged
MH  - Anthropometry
MH  - Aorta/physiology
MH  - Blood Pressure/physiology
MH  - Carotid Arteries/anatomy & histology/physiology
MH  - Female
MH  - Heart Rate/physiology
MH  - High-Intensity Interval Training/*methods
MH  - Humans
MH  - Lipids/blood
MH  - Lower Extremity/*physiology
MH  - Male
MH  - Middle Aged
MH  - Pulse Wave Analysis
MH  - Upper Extremity/*physiology
MH  - Vascular Stiffness/*physiology
PMC - PMC5474160
MID - NIHMS847774
COIS- The authors declare no conflict of interest. The results of the study are 
      presented clearly, honestly, and without fabrication, falsification, or 
      inappropriate data manipulation. The results of the present investigation do not 
      constitute endorsement by the American College of Sports Medicine.
EDAT- 2017/02/07 06:00
MHDA- 2017/12/09 06:00
PMCR- 2018/07/01
CRDT- 2017/02/07 06:00
PHST- 2017/02/07 06:00 [pubmed]
PHST- 2017/12/09 06:00 [medline]
PHST- 2017/02/07 06:00 [entrez]
PHST- 2018/07/01 00:00 [pmc-release]
AID - 10.1249/MSS.0000000000001229 [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 2017 Jul;49(7):1404-1411. doi: 
      10.1249/MSS.0000000000001229.