PMID- 28166246
OWN - NLM
STAT- MEDLINE
DCOM- 20170825
LR  - 20190208
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 2
DP  - 2017
TI  - Soluble human leukocyte antigen -G during pregnancy and infancy in Benin: 
      Mother/child resemblance and association with the risk of malaria infection and 
      low birth weight.
PG  - e0171117
LID - 10.1371/journal.pone.0171117 [doi]
LID - e0171117
AB  - Human leukocyte antigen (HLA) G is a tolerogenic molecule involved in the 
      maternal-fetal immune tolerance phenomenon. Its expression during some infectious 
      diseases leading to immune evasion has been established. A first study conducted 
      in Benin has shown that the production of soluble HLA-G (sHLA-G) during the first 
      months of life is strongly correlated with the maternal level at delivery and 
      associated with low birth weight and malaria. However sHLA-G measurements during 
      pregnancy were not available for mothers and furthermore, to date the evolution 
      of sHLA-G in pregnancy is not documented in African populations. To extend these 
      previous findings, between January 2010 and June 2013, 400 pregnant women of a 
      malaria preventive trial and their newborns were followed up in Benin until the 
      age of 2 years. Soluble HLA-G was measured 3 times during pregnancy and 
      repeatedly during the 2 years follow-up to explore how sHLA-G evolved and the 
      factors associated. During pregnancy, plasma levels of sHLA-G remained stable and 
      increased significantly at delivery (p<0.001). Multigravid women seemed to have 
      the highest levels (p = 0.039). In infants, the level was highest in cord blood 
      and decreased before stabilizing after 18 months (p<0.001). For children, a high 
      level of sHLA-G was associated with malaria infection during the follow-up (p = 
      0.02) and low birth weight (p = 0.06). The mean level of sHLA-G during infancy 
      was strongly correlated with the mother's level during pregnancy (<0.001), and 
      not only at delivery. Moreover, mothers with placental malaria infection had a 
      higher probability of giving birth to a child with a high level of sHLA-g (p = 
      0.006). High sHLA-G levels during pregnancy might be associated with immune 
      tolerance related to placental malaria. Further studies are needed but this study 
      provides a first insight concerning the potential role of sHLA-G as a biomarker 
      of weakness for newborns and infants.
FAU - d'Almeida, Tania C
AU  - d'Almeida TC
AD  - Universite Pierre et Marie Curie, Paris, France.
AD  - UMR 216-MERIT, Institut de Recherche pour le Developpement, Faculte de Pharmacie 
      - Universite Paris Descartes, Sorbonne Paris-Cite, Paris, France.
FAU - Sadissou, Ibrahim
AU  - Sadissou I
AD  - UMR 216-MERIT, Institut de Recherche pour le Developpement, Faculte de Pharmacie 
      - Universite Paris Descartes, Sorbonne Paris-Cite, Paris, France.
AD  - Centre d'Etude et de Recherche sur le Paludisme Associe a la Grossesse et a 
      l'Enfance, Faculte des Sciences de la Sante, Cotonou, Benin.
AD  - Universite d'Abomey-Calavi, Cotonou, Benin.
AD  - Division of Clinical Immunology, School of Medicine of Ribeirao Preto, University 
      of Sao Paulo, Brazil.
FAU - Milet, Jacqueline
AU  - Milet J
AD  - UMR 216-MERIT, Institut de Recherche pour le Developpement, Faculte de Pharmacie 
      - Universite Paris Descartes, Sorbonne Paris-Cite, Paris, France.
AD  - Universite Paris Descartes, Sorbonne Paris Cite, Paris, France.
FAU - Cottrell, Gilles
AU  - Cottrell G
AD  - UMR 216-MERIT, Institut de Recherche pour le Developpement, Faculte de Pharmacie 
      - Universite Paris Descartes, Sorbonne Paris-Cite, Paris, France.
AD  - Universite Paris Descartes, Sorbonne Paris Cite, Paris, France.
FAU - Mondiere, Amandine
AU  - Mondiere A
AD  - UMR 216-MERIT, Institut de Recherche pour le Developpement, Campus de la Faculte 
      des Sciences de la Sante (FSS) et de l'Institut des Sciences Biomedicales 
      Appliquees (ISBA), Cotonou, Benin.
FAU - Avokpaho, Euripide
AU  - Avokpaho E
AD  - Ecole Pasteur - CNAM de sante publique, Paris, France.
FAU - Gineau, Laure
AU  - Gineau L
AD  - UMR 216-MERIT, Institut de Recherche pour le Developpement, Faculte de Pharmacie 
      - Universite Paris Descartes, Sorbonne Paris-Cite, Paris, France.
FAU - Sabbagh, Audrey
AU  - Sabbagh A
AD  - UMR 216-MERIT, Institut de Recherche pour le Developpement, Faculte de Pharmacie 
      - Universite Paris Descartes, Sorbonne Paris-Cite, Paris, France.
FAU - Massougbodji, Achille
AU  - Massougbodji A
AD  - Centre d'Etude et de Recherche sur le Paludisme Associe a la Grossesse et a 
      l'Enfance, Faculte des Sciences de la Sante, Cotonou, Benin.
AD  - Universite d'Abomey-Calavi, Cotonou, Benin.
FAU - Moutairou, Kabirou
AU  - Moutairou K
AD  - Universite d'Abomey-Calavi, Cotonou, Benin.
FAU - Donadi, Eduardo A
AU  - Donadi EA
AD  - Division of Clinical Immunology, School of Medicine of Ribeirao Preto, University 
      of Sao Paulo, Brazil.
FAU - Favier, Benoit
AU  - Favier B
AD  - CEA, Institut des Maladies Emergentes et des Therapies Innovantes (IMETI), 
      Service de Recherches en Hemato-Immunologie (SRHI), Hopital Saint-Louis, IUH, 
      Paris, France.
AD  - Universite Paris Diderot, Sorbonne Paris Cite, IUH, Hopital Saint-Louis, UMR_E5, 
      IUH, Paris, France.
FAU - Carosella, Edgardo
AU  - Carosella E
AD  - CEA, Institut des Maladies Emergentes et des Therapies Innovantes (IMETI), 
      Service de Recherches en Hemato-Immunologie (SRHI), Hopital Saint-Louis, IUH, 
      Paris, France.
AD  - Universite Paris Diderot, Sorbonne Paris Cite, IUH, Hopital Saint-Louis, UMR_E5, 
      IUH, Paris, France.
FAU - Moreau, Philippe
AU  - Moreau P
AD  - CEA, Institut des Maladies Emergentes et des Therapies Innovantes (IMETI), 
      Service de Recherches en Hemato-Immunologie (SRHI), Hopital Saint-Louis, IUH, 
      Paris, France.
AD  - Universite Paris Diderot, Sorbonne Paris Cite, IUH, Hopital Saint-Louis, UMR_E5, 
      IUH, Paris, France.
FAU - Rouas-Freiss, Nathalie
AU  - Rouas-Freiss N
AD  - CEA, Institut des Maladies Emergentes et des Therapies Innovantes (IMETI), 
      Service de Recherches en Hemato-Immunologie (SRHI), Hopital Saint-Louis, IUH, 
      Paris, France.
AD  - Universite Paris Diderot, Sorbonne Paris Cite, IUH, Hopital Saint-Louis, UMR_E5, 
      IUH, Paris, France.
FAU - Courtin, David
AU  - Courtin D
AD  - UMR 216-MERIT, Institut de Recherche pour le Developpement, Faculte de Pharmacie 
      - Universite Paris Descartes, Sorbonne Paris-Cite, Paris, France.
AD  - Universite Paris Descartes, Sorbonne Paris Cite, Paris, France.
FAU - Garcia, Andre
AU  - Garcia A
AD  - Universite Pierre et Marie Curie, Paris, France.
AD  - UMR 216-MERIT, Institut de Recherche pour le Developpement, Faculte de Pharmacie 
      - Universite Paris Descartes, Sorbonne Paris-Cite, Paris, France.
AD  - Centre d'Etude et de Recherche sur le Paludisme Associe a la Grossesse et a 
      l'Enfance, Faculte des Sciences de la Sante, Cotonou, Benin.
LA  - eng
PT  - Journal Article
DEP - 20170206
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Benin/epidemiology
MH  - *Disease Susceptibility
MH  - Female
MH  - HLA-G Antigens/*blood
MH  - Humans
MH  - Infant
MH  - *Infant, Low Birth Weight
MH  - Infant, Newborn
MH  - Malaria/*blood/epidemiology/*etiology
MH  - Pregnancy
MH  - Young Adult
PMC - PMC5293225
COIS- The authors have declared that no competing interests exist.
EDAT- 2017/02/07 06:00
MHDA- 2017/08/26 06:00
PMCR- 2017/02/06
CRDT- 2017/02/07 06:00
PHST- 2016/08/11 00:00 [received]
PHST- 2017/01/04 00:00 [accepted]
PHST- 2017/02/07 06:00 [entrez]
PHST- 2017/02/07 06:00 [pubmed]
PHST- 2017/08/26 06:00 [medline]
PHST- 2017/02/06 00:00 [pmc-release]
AID - PONE-D-16-32141 [pii]
AID - 10.1371/journal.pone.0171117 [doi]
PST - epublish
SO  - PLoS One. 2017 Feb 6;12(2):e0171117. doi: 10.1371/journal.pone.0171117. 
      eCollection 2017.