PMID- 28166650
OWN - NLM
STAT- MEDLINE
DCOM- 20170330
LR  - 20170330
IS  - 1029-2470 (Electronic)
IS  - 1029-2470 (Linking)
VI  - 51
IP  - 2
DP  - 2017 Feb
TI  - The effects of exercise load during development on oxidative stress levels and 
      antioxidant potential in adulthood.
PG  - 179-186
LID - 10.1080/10715762.2017.1291939 [doi]
AB  - The objective of this study was to elucidate the impact of physical activity 
      during the growth period as well as on oxidative stress and antioxidative 
      potential in adulthood. The experimental animals used were four-week old male 
      Wistar rats, which were randomly divided into three groups. The exercise loads 
      were as follows: control (CON), treadmill exercise (TE), and jumping exercise 
      (JE). The exercise was performed at the same time of day, at a frequency of five 
      days per week, for eight weeks. Derivatives of reactive oxygen metabolites 
      (d-ROSs) and biological antioxidant potential (BAP) were measured during periods 
      of rest prior to commencement of the experiment and after the experiment. 
      Analysis was conducted using a Wilcoxon signed-rank test and Schaffer's multiple 
      comparison procedure and the significance level was set at p < 0.05. The percent 
      increase in d-ROM levels in the JE group, which experienced short-duration 
      intense exercise loads, was higher than that in the TE group, which experienced 
      moderately intense exercise loads. However, BAP, which is an index of antioxidant 
      potential, markedly decreased in adulthood in the CON group, as compared to that 
      in the developmental period, whereas the exercise groups showed no notable 
      changes in BAP levels. Oxidative stress levels and antioxidant potential are 
      affected differently in adulthood, depending on the intensity of sustained 
      exercise loads experienced during development. Results suggested that in order to 
      increase antioxidant potential, while taking oxidative stress production into 
      account, moderately intense exercise loads are more desirable than highly intense 
      exercise loads.
FAU - Lee, S
AU  - Lee S
AD  - a Department of Physical Therapy , Aomori University of Health and Welfare , 
      Aomori-shi , Japan.
FAU - Hashimoto, J
AU  - Hashimoto J
AD  - a Department of Physical Therapy , Aomori University of Health and Welfare , 
      Aomori-shi , Japan.
FAU - Suzuki, T
AU  - Suzuki T
AD  - a Department of Physical Therapy , Aomori University of Health and Welfare , 
      Aomori-shi , Japan.
FAU - Satoh, A
AU  - Satoh A
AD  - b Department of Nursing , Hirosaki University of Health and Welfare , 
      Hirosaki-shi , Japan.
LA  - eng
PT  - Journal Article
DEP - 20170306
PL  - England
TA  - Free Radic Res
JT  - Free radical research
JID - 9423872
RN  - 0 (Antioxidants)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - *Body Weight
MH  - Dietary Supplements
MH  - Lipid Peroxidation
MH  - Male
MH  - Oxidative Stress/*physiology
MH  - Physical Conditioning, Animal/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Reactive Oxygen Species/*metabolism
OTO - NOTNLM
OT  - Development
OT  - antioxidant potential
OT  - exercise load
OT  - oxidative stress
EDAT- 2017/02/09 06:00
MHDA- 2017/03/31 06:00
CRDT- 2017/02/08 06:00
PHST- 2017/02/09 06:00 [pubmed]
PHST- 2017/03/31 06:00 [medline]
PHST- 2017/02/08 06:00 [entrez]
AID - 10.1080/10715762.2017.1291939 [doi]
PST - ppublish
SO  - Free Radic Res. 2017 Feb;51(2):179-186. doi: 10.1080/10715762.2017.1291939. Epub 
      2017 Mar 6.