PMID- 28167926
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 8
DP  - 2017
TI  - Disrupted Causal Connectivity Anchored in the Posterior Cingulate Cortex in 
      Amnestic Mild Cognitive Impairment.
PG  - 10
LID - 10.3389/fneur.2017.00010 [doi]
LID - 10
AB  - Amnestic mild cognitive impairment (aMCI) is a transitional stage between normal 
      cognitive aging and Alzheimer's disease. Previous studies have found that 
      neuronal activity and functional connectivity impaired in many functional 
      networks, especially in the default mode network (DMN), which is related to 
      significantly impaired cognitive and memory functions in aMCI patients. However, 
      few studies have focused on the effective connectivity of the DMN and its 
      subsystems in aMCI patients. The posterior cingulate cortex (PCC) is considered a 
      crucial region in connectivity of the DMN and its key subsystem. In this study, 
      using the coefficient Granger causality analysis approach and using the PCC as 
      the region of interest, we explored changes in the DMN and its subsystems in 
      effective connectivity with other brain regions as well as in correlations among 
      them in 16 aMCI patients and 15 age-matched cognitively normal elderly. Results 
      showed decreased effective connectivity from PCC to whole brain in the left 
      prefrontal cortex, the left medial temporal lobe (MTL), the left fusiform gyrus 
      (FG), and the left cerebellar hemisphere, meanwhile, right temporal lobe showed 
      increased effective connectivity from PCC to the whole brain in aMCI patients 
      compared with normal control. In addition, compared with the normal controls, 
      increased effective connectivity of the whole brain to the PCC in aMCI patients 
      was found in the right thalamus, left medial temporal lobe, left FG, and left 
      cerebellar hemisphere. Compared with the normal controls, no reduced effective 
      connectivity was found in any brain regions from the whole brain to the PCC in 
      aMCI patients. The reduced effective connectivity of the PCC to left MTL showed 
      negative correlation trend with neuropsychological tests (Auditory Verbal 
      Learning Test-immediate recall and clock drawing test) in aMCI patients. Our 
      study shows that aMCI patients have abnormalities in effective connectivity 
      within the PCC-centered DMN network and its posterior subsystems as well as in 
      the cerebellar hemisphere and thalamus. Abnormal integration of networks may be 
      related to cognitive and memory impairment and compensation mechanisms in aMCI 
      patients.
FAU - Yang, Hong
AU  - Yang H
AD  - Department of Radiology, The First Affiliated Hospital of College of Medicine, 
      Zhejiang University , Hangzhou , China.
FAU - Wang, Chengwei
AU  - Wang C
AD  - Department of CT/MRI, The First Affiliated Hospital of the Medical College, 
      Shihezi University, Shihezi, China; Department of Radiology, Tongji Hospital, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei, China.
FAU - Zhang, Yumei
AU  - Zhang Y
AD  - Department of Radiology, The First Affiliated Hospital of College of Medicine, 
      Zhejiang University, Hangzhou, China; Department of CT/MRI, The First Affiliated 
      Hospital of the Medical College, Shihezi University, Shihezi, China.
FAU - Xia, Liming
AU  - Xia L
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology , Wuhan, Hubei , China.
FAU - Feng, Zhan
AU  - Feng Z
AD  - Department of Radiology, The First Affiliated Hospital of College of Medicine, 
      Zhejiang University , Hangzhou , China.
FAU - Li, Deqiang
AU  - Li D
AD  - Department of Neurology, The First Affiliated Hospital of College of Medicine, 
      Zhejiang University , Hangzhou , China.
FAU - Xu, Shunliang
AU  - Xu S
AD  - Department of Radiology, The First Affiliated Hospital of College of Medicine, 
      Zhejiang University , Hangzhou , China.
FAU - Xie, Haiyan
AU  - Xie H
AD  - Department of Psychiatry, The Fourth Affiliated Hospital Zhejiang University 
      School of Medicine , Yiwu , China.
FAU - Chen, Feng
AU  - Chen F
AD  - Department of Radiology, The First Affiliated Hospital of College of Medicine, 
      Zhejiang University , Hangzhou , China.
FAU - Shi, Yushu
AU  - Shi Y
AD  - Department of Radiology, The First Affiliated Hospital of College of Medicine, 
      Zhejiang University , Hangzhou , China.
FAU - Wang, Jue
AU  - Wang J
AD  - Center for Cognition and Brain Disorders, Affiliated Hospital, Hangzhou Normal 
      University , Hangzhou , China.
LA  - eng
PT  - Journal Article
DEP - 20170124
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC5256067
OTO - NOTNLM
OT  - Granger causality analysis
OT  - amnestic mild cognitive impairment
OT  - default mode network
OT  - effective connectivity
OT  - resting fMRI
EDAT- 2017/02/09 06:00
MHDA- 2017/02/09 06:01
PMCR- 2017/01/24
CRDT- 2017/02/08 06:00
PHST- 2016/08/27 00:00 [received]
PHST- 2017/01/09 00:00 [accepted]
PHST- 2017/02/08 06:00 [entrez]
PHST- 2017/02/09 06:00 [pubmed]
PHST- 2017/02/09 06:01 [medline]
PHST- 2017/01/24 00:00 [pmc-release]
AID - 10.3389/fneur.2017.00010 [doi]
PST - epublish
SO  - Front Neurol. 2017 Jan 24;8:10. doi: 10.3389/fneur.2017.00010. eCollection 2017.