PMID- 28167928 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220410 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 8 DP - 2017 TI - Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management. PG - 6 LID - 10.3389/fendo.2017.00006 [doi] LID - 6 AB - Type 2 diabetes mellitus (T2DM) is a global pandemic, as evident from the global cartographic picture of diabetes by the International Diabetes Federation (http://www.diabetesatlas.org/). Diabetes mellitus is a chronic, progressive, incompletely understood metabolic condition chiefly characterized by hyperglycemia. Impaired insulin secretion, resistance to tissue actions of insulin, or a combination of both are thought to be the commonest reasons contributing to the pathophysiology of T2DM, a spectrum of disease originally arising from tissue insulin resistance and gradually progressing to a state characterized by complete loss of secretory activity of the beta cells of the pancreas. T2DM is a major contributor to the very large rise in the rate of non-communicable diseases affecting developed as well as developing nations. In this mini review, we endeavor to outline the current management principles, including the spectrum of medications that are currently used for pharmacologic management, for lowering the elevated blood glucose in T2DM. FAU - Chaudhury, Arun AU - Chaudhury A AD - GIM Foundation , Little Rock, AR , USA. FAU - Duvoor, Chitharanjan AU - Duvoor C AD - GIM Foundation, Little Rock, AR, USA; University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA. FAU - Reddy Dendi, Vijaya Sena AU - Reddy Dendi VS AD - Christus Trinity Mother Frances Hospital , Tyler, TX , USA. FAU - Kraleti, Shashank AU - Kraleti S AD - University of Arkansas for Medical Sciences (UAMS) , Little Rock, AR , USA. FAU - Chada, Aditya AU - Chada A AD - GIM Foundation, Little Rock, AR, USA; University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA. FAU - Ravilla, Rahul AU - Ravilla R AD - GIM Foundation, Little Rock, AR, USA; University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA. FAU - Marco, Asween AU - Marco A AD - GIM Foundation, Little Rock, AR, USA; University of Arkansas for Little Rock (UALR), Little Rock, AR, USA. FAU - Shekhawat, Nawal Singh AU - Shekhawat NS AD - GIM Foundation, Little Rock, AR, USA; Tutwiler Clinic, Tutwiler, MS, USA. FAU - Montales, Maria Theresa AU - Montales MT AD - University of Arkansas for Medical Sciences (UAMS) , Little Rock, AR , USA. FAU - Kuriakose, Kevin AU - Kuriakose K AD - Vanderbilt University , Nashville, TN , USA. FAU - Sasapu, Appalanaidu AU - Sasapu A AD - University of Arkansas for Medical Sciences (UAMS) , Little Rock, AR , USA. FAU - Beebe, Alexandria AU - Beebe A AD - Arkansas Department of Health , Little Rock, AR , USA. FAU - Patil, Naveen AU - Patil N AD - Arkansas Department of Health , Little Rock, AR , USA. FAU - Musham, Chaitanya K AU - Musham CK AD - St. Vincent Infirmary , Little Rock, AR , USA. FAU - Lohani, Govinda Prasad AU - Lohani GP AD - Baptist Hospital SpringHill , North Little Rock, AR , USA. FAU - Mirza, Wasique AU - Mirza W AD - The Wright Center for Graduate Medical Education , Scranton, PA , USA. LA - eng PT - Journal Article PT - Review DEP - 20170124 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 PMC - PMC5256065 OTO - NOTNLM OT - chronic OT - clinical management OT - diabetes OT - insulin OT - primary care EDAT- 2017/02/09 06:00 MHDA- 2017/02/09 06:01 PMCR- 2017/01/01 CRDT- 2017/02/08 06:00 PHST- 2016/09/14 00:00 [received] PHST- 2017/01/09 00:00 [accepted] PHST- 2017/02/08 06:00 [entrez] PHST- 2017/02/09 06:00 [pubmed] PHST- 2017/02/09 06:01 [medline] PHST- 2017/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2017.00006 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2017 Jan 24;8:6. doi: 10.3389/fendo.2017.00006. eCollection 2017.