PMID- 28168045
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2090-004X (Print)
IS  - 2090-0058 (Electronic)
IS  - 2090-004X (Linking)
VI  - 2017
DP  - 2017
TI  - Transient Peripapillary Retinoschisis in Glaucomatous Eyes.
PG  - 1536030
LID - 10.1155/2017/1536030 [doi]
LID - 1536030
AB  - Purpose. To investigate transient focal microcystic retinoschisis in glaucomatous 
      eyes in images obtained with several imaging techniques used in daily glaucoma 
      care. Methods. Images of 117 glaucoma patients and 91 healthy subjects 
      participating in a large prospective follow-up study into glaucoma imaging were 
      reviewed. Participants were measured with spectral domain optical coherence 
      tomography (SD-OCT), scanning laser polarimetry (SLP), scanning laser tomography 
      (SLT), and standard automated perimetry (SAP). The presence of a focal 
      retinoschisis in SD-OCT was observed and correlated to SLP, SLT, and SAP 
      measurements, both cross-sectionally and longitudinally. Results. Seven out of 
      117 glaucoma patients showed a transient, localised, peripapillary, heterogeneous 
      microcystic schisis of the retinal nerve fiber layer (RNFL) and sometimes other 
      retinal layers as well in SD-OCT. None of the healthy eyes showed this phenomenon 
      nor did any of the other imaging techniques display it as detailed and 
      consistently as did the SD-OCT. SAP showed a temporarily decreased focal retinal 
      sensitivity during the retinoschisis and we found no signs of glaucomatous 
      progression related to the retinoschisis. Conclusions. Transient microcystic 
      retinoschisis appears to be associated with glaucomatous wedge defects in the 
      RNFL. It was best observed with SD-OCT and it was absent in healthy eyes. We 
      found no evidence that the retinoschisis predicted glaucomatous progression.
FAU - van der Schoot, Josine
AU  - van der Schoot J
AUID- ORCID: 0000-0001-5299-9969
AD  - Rotterdam Ophthalmic Institute, The Rotterdam Eye Hospital, Rotterdam, 
      Netherlands; Glaucoma Service, The Rotterdam Eye Hospital, Rotterdam, 
      Netherlands.
FAU - Vermeer, Koenraad A
AU  - Vermeer KA
AD  - Rotterdam Ophthalmic Institute, The Rotterdam Eye Hospital, Rotterdam, 
      Netherlands.
FAU - Lemij, Hans G
AU  - Lemij HG
AD  - Glaucoma Service, The Rotterdam Eye Hospital, Rotterdam, Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20170112
PL  - United States
TA  - J Ophthalmol
JT  - Journal of ophthalmology
JID - 101524199
PMC - PMC5266822
COIS- Josine van der Schoot and Koenraad A. Vermeer have no competing interests. Hans 
      G. Lemij carried out provision of equipment by Carl Zeiss Meditec Inc. (S).
EDAT- 2017/02/09 06:00
MHDA- 2017/02/09 06:01
PMCR- 2017/01/12
CRDT- 2017/02/08 06:00
PHST- 2016/09/26 00:00 [received]
PHST- 2016/12/22 00:00 [accepted]
PHST- 2017/02/08 06:00 [entrez]
PHST- 2017/02/09 06:00 [pubmed]
PHST- 2017/02/09 06:01 [medline]
PHST- 2017/01/12 00:00 [pmc-release]
AID - 10.1155/2017/1536030 [doi]
PST - ppublish
SO  - J Ophthalmol. 2017;2017:1536030. doi: 10.1155/2017/1536030. Epub 2017 Jan 12.