PMID- 28168795
OWN - NLM
STAT- MEDLINE
DCOM- 20170828
LR  - 20181202
IS  - 1522-7278 (Electronic)
IS  - 1520-4081 (Linking)
VI  - 32
IP  - 6
DP  - 2017 Jun
TI  - Nonylphenol increases tumor formation and growth by suppressing 
      gender-independent lymphocyte proliferation and macrophage activation.
PG  - 1679-1687
LID - 10.1002/tox.22385 [doi]
AB  - Nonylphenol (NP) is a well-known endocrine disruptor that influences sexual and 
      reproductive development. Here, we investigated whether NP affects immune 
      responses that are associated with tumor initiation and progression. When spleen 
      cells were incubated with lipopolysaccharide (LPS) and concanavalin A in the 
      presence of 10(-4) M NP, the proliferation of B and T lymphocytes was reduced 
      compared with that in controls, in a gender-independent fashion. While 10(-4) M 
      NP also decreased the production of nitric oxide (NO) in LPS-stimulated bone 
      marrow-derived macrophages (BMDMs), no changes in NO production were detected 
      following treatment with 10(-5) M NP. LPS-stimulated expression of iNOS, COX2, 
      IL-6 and TNF-alpha in BMDMs was reduced after 6 or 18 hours of incubation with 10(-5) 
      M NP. Furthermore, when mice were pre-exposed to NP for 7 days prior to the 
      injection of B16F10 melanoma cells, the rates of tumor nodule formation and 
      relative tumor growth were higher than those in the control group. In vivo 
      immunosuppressive effect was also clarified by the inhibition of proliferation in 
      B/T lymphocyte and cytokine production in peritoneal macrophages from the mice 
      pretreated with NP for 7 days. Taken together, these data demonstrate that NP 
      could affect the immune responses of lymphocytes and macrophages, leading to the 
      suppression of their tumor-preventing ability. This suggests that individuals at 
      high risk for tumor development should avoid frequent exposure to NP and other 
      endocrine disruptors.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Lee, Jae-Wook
AU  - Lee JW
AD  - Department of Bioscience and Biotechnology, Sejong University, Seoul, 05006, 
      Republic of Korea.
FAU - Han, Hae-Kyoung
AU  - Han HK
AD  - Department of Bioscience and Biotechnology, Sejong University, Seoul, 05006, 
      Republic of Korea.
FAU - Park, Sojin
AU  - Park S
AD  - Department of Bioscience and Biotechnology, Sejong University, Seoul, 05006, 
      Republic of Korea.
FAU - Moon, Eun-Yi
AU  - Moon EY
AD  - Department of Bioscience and Biotechnology, Sejong University, Seoul, 05006, 
      Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20170207
PL  - United States
TA  - Environ Toxicol
JT  - Environmental toxicology
JID - 100885357
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Interleukin-6)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Phenols)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 11028-71-0 (Concanavalin A)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 79F6A2ILP5 (nonylphenol)
RN  - EC 1.14.13.39 (NOS2 protein, human)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/drug effects
MH  - Cell Line, Tumor
MH  - Cell Proliferation/drug effects
MH  - Concanavalin A/immunology
MH  - Endocrine Disruptors/*toxicity
MH  - Interleukin-6/metabolism
MH  - Lipopolysaccharides/immunology
MH  - Lymphocyte Activation/drug effects
MH  - Lymphocytes/drug effects/*immunology
MH  - Macrophage Activation/*drug effects
MH  - Macrophages, Peritoneal/*drug effects/immunology
MH  - Male
MH  - Melanoma, Experimental/*chemically induced/immunology
MH  - Mice
MH  - Nitric Oxide/metabolism
MH  - Nitric Oxide Synthase Type II/metabolism
MH  - Phenols/*toxicity
MH  - Spleen/cytology/drug effects
MH  - T-Lymphocytes/drug effects
MH  - Tumor Necrosis Factor-alpha/metabolism
OTO - NOTNLM
OT  - B/T lymphocytes
OT  - endocrine disruptor
OT  - macrophages
OT  - nonylphenol
OT  - tumor growth
EDAT- 2017/02/09 06:00
MHDA- 2017/08/29 06:00
CRDT- 2017/02/08 06:00
PHST- 2016/08/29 00:00 [received]
PHST- 2016/11/20 00:00 [revised]
PHST- 2016/11/30 00:00 [accepted]
PHST- 2017/02/09 06:00 [pubmed]
PHST- 2017/08/29 06:00 [medline]
PHST- 2017/02/08 06:00 [entrez]
AID - 10.1002/tox.22385 [doi]
PST - ppublish
SO  - Environ Toxicol. 2017 Jun;32(6):1679-1687. doi: 10.1002/tox.22385. Epub 2017 Feb 
      7.