PMID- 28168802
OWN - NLM
STAT- MEDLINE
DCOM- 20180918
LR  - 20191210
IS  - 1475-097X (Electronic)
IS  - 1475-0961 (Linking)
VI  - 38
IP  - 2
DP  - 2018 Mar
TI  - Validation of impedance cardiography in pulmonary arterial hypertension.
PG  - 254-260
LID - 10.1111/cpf.12408 [doi]
AB  - BACKGROUND: Non-invasive methods of measuring cardiac output are highly desirable 
      in pulmonary arterial hypertension (PAH). We therefore sought to validate 
      impedance cardiography (ICG) against thermodilution (TD) and cardiac magnetic 
      resonance (CMR) in the measurement of cardiac output in patients under 
      investigation for PAH. METHODS: A prospective, cross-sectional study was 
      performed to compare single-point measurements of cardiac output obtained by 
      impedance cardiography (CO(ICG) ) technology (PhysioFlow((R)) ) with (i) 
      contemporaneous TD measurements (CO(TD) ) at rest and steady-state exercise 
      during right heart catheterization and (ii) CMR measurements (CO(CMR) ) at rest 
      obtained within 72 h. RESULTS: Paired CO(ICG) and CO(TD) measurements were 
      obtained in 25 subjects at rest and 16 subjects at exercise. CO(CMR) measurements 
      were obtained in 16 subjects at rest. There was unsatisfactory correlation and 
      agreement between CO(ICG) and CO(TD) at rest (r = 0.42, P = 0.035; bias: 
      1.21 l min(-1) , 95% CI: -2.33 to 4.75 l min(-1) ) and exercise (r = .65, 
      P = .007; bias: 1.41 l min(-1) ; 95% CI: -3.99 to 6.81 l min(-1) ) and in the 
      change in CO(ICG) and CO(TD) from rest to exercise (r = 0.53, P = 0.033; bias: 
      0.76 l min(-1) , 95% CI: -3.74 to 5.26 l min(-1) ). There was also a lack of 
      correlation and unsatisfactory agreement between resting CO(ICG) and CO(CMR) 
      (r = 0.38, P = 0.1; bias: 1.40 l min(-1) , 95% CI: -2.48 to 5.28 l min(-1) ). In 
      contrast, there was close correlation and agreement between resting CO(TD) and 
      CO(CMR) (r = 0.87, P<0.001; bias: -0.16 l min(-1) , 95% CI: -1.97 to 1.65). 
      CONCLUSIONS: In a representative population of patients under investigation for 
      PAH, ICG showed insufficient qualitative and quantitative value in the 
      measurement of resting and exercise cardiac output when compared with TD and CMR.
CI  - (c) 2017 Scandinavian Society of Clinical Physiology and Nuclear Medicine. 
      Published by John Wiley & Sons Ltd.
FAU - Panagiotou, Marios
AU  - Panagiotou M
AD  - Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Glasgow, UK.
FAU - Vogiatzis, Ioannis
AU  - Vogiatzis I
AD  - Faculty of Physical Education and Sports Sciences, National and Kapodistrian 
      University of Athens, Athens, Greece.
AD  - Faculty of Health and Life Sciences, Department of Sport, Exercise and 
      Rehabilitation, Northumbria University, Newcastle UponTyne, UK.
FAU - Jayasekera, Geeshath
AU  - Jayasekera G
AD  - Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Glasgow, UK.
FAU - Louvaris, Zafeiris
AU  - Louvaris Z
AD  - Faculty of Physical Education and Sports Sciences, National and Kapodistrian 
      University of Athens, Athens, Greece.
AD  - Faculty of Kinesiology and Rehabilitation Sciences, Department of Rehabilitation 
      Sciences KU Leuven, Division of Respiratory Rehabilitation, University Hospitals 
      Leuven, Belgium.
FAU - Mackenzie, Alison
AU  - Mackenzie A
AD  - Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Glasgow, UK.
FAU - Mcglinchey, Neil
AU  - Mcglinchey N
AD  - Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Glasgow, UK.
FAU - Baker, Julien S
AU  - Baker JS
AD  - Institute of Clinical Exercise and Health Science, University of the West of 
      Scotland, Hamilton, UK.
FAU - Church, Alistair C
AU  - Church AC
AD  - Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Glasgow, UK.
FAU - Peacock, Andrew J
AU  - Peacock AJ
AD  - Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Glasgow, UK.
FAU - Johnson, Martin K
AU  - Johnson MK
AD  - Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Glasgow, UK.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Validation Study
DEP - 20170206
PL  - England
TA  - Clin Physiol Funct Imaging
JT  - Clinical physiology and functional imaging
JID - 101137604
SB  - IM
CIN - Clin Physiol Funct Imaging. 2018 Jul;38(4):725. PMID: 28941050
MH  - Aged
MH  - Cardiac Catheterization
MH  - *Cardiac Output
MH  - *Cardiography, Impedance
MH  - Cross-Sectional Studies
MH  - Exercise Test
MH  - Female
MH  - Humans
MH  - Hypertension, Pulmonary/*diagnosis/diagnostic imaging/physiopathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Thermodilution
OTO - NOTNLM
OT  - cardiac magnetic resonance
OT  - cardiac output
OT  - thermodilution
EDAT- 2017/02/09 06:00
MHDA- 2018/09/19 06:00
CRDT- 2017/02/08 06:00
PHST- 2016/08/29 00:00 [received]
PHST- 2016/11/11 00:00 [accepted]
PHST- 2017/02/09 06:00 [pubmed]
PHST- 2018/09/19 06:00 [medline]
PHST- 2017/02/08 06:00 [entrez]
AID - 10.1111/cpf.12408 [doi]
PST - ppublish
SO  - Clin Physiol Funct Imaging. 2018 Mar;38(2):254-260. doi: 10.1111/cpf.12408. Epub 
      2017 Feb 6.