PMID- 28174256
OWN - NLM
STAT- MEDLINE
DCOM- 20180220
LR  - 20230120
IS  - 1943-4456 (Electronic)
IS  - 0091-7451 (Linking)
VI  - 81
DP  - 2016
TI  - A Time for MYC: Metabolism and Therapy.
PG  - 79-83
LID - 10.1101/sqb.2016.81.031153 [doi]
AB  - The MYC oncogene is frequently deregulated in human cancers, whereas the 
      proto-oncogene is exquisitely, tightly regulated in normal cells. Deregulated MYC 
      drives transcriptional imbalance, thereby altering metabolism and disrupting the 
      circadian Bmal1-Clock E-box-dependent transcriptional circuitry. Sustained 
      oncogenic MYC expression drives a constitutive growth program with mammalian 
      target of rapamycin (mTOR) activation that renders cells dependent on nutrients, 
      such that glucose or glutamine deprivation could trigger cell death and key 
      enzymes such as lactate dehydrogenase A (LDHA) and glutaminase (GLS) amenable for 
      targeting in cancers. Further, MYC-mediated suppression of the circadian clock is 
      surmised to suspend the inhibitory effect of Bmal1-Clock on metabolism, allowing 
      for MYC-driven cancer cells to reach a higher state of anabolic metabolism. 
      Hence, metabolic therapy could be deployed, particularly at specific times of the 
      day, to diminish side effects to normal tissues while maintaining antitumor 
      efficacy.
CI  - (c) 2016 Dang; Published by Cold Spring Harbor Laboratory Press.
FAU - Dang, Chi V
AU  - Dang CV
AD  - Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, Pennsylvania 19104.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170207
PL  - United States
TA  - Cold Spring Harb Symp Quant Biol
JT  - Cold Spring Harbor symposia on quantitative biology
JID - 1256107
RN  - 0 (MAS1 protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0RH81L854J (Glutamine)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Cell Proliferation/physiology
MH  - Glucose/*metabolism
MH  - Glutamine/*metabolism
MH  - Humans
MH  - Neoplasms/*metabolism
MH  - Promoter Regions, Genetic/*genetics
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogene Proteins c-myc/*genetics
EDAT- 2017/02/09 06:00
MHDA- 2018/02/21 06:00
CRDT- 2017/02/09 06:00
PHST- 2017/02/09 06:00 [pubmed]
PHST- 2018/02/21 06:00 [medline]
PHST- 2017/02/09 06:00 [entrez]
AID - sqb.2016.81.031153 [pii]
AID - 10.1101/sqb.2016.81.031153 [doi]
PST - ppublish
SO  - Cold Spring Harb Symp Quant Biol. 2016;81:79-83. doi: 10.1101/sqb.2016.81.031153. 
      Epub 2017 Feb 7.