PMID- 28174595
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1744-859X (Print)
IS  - 1744-859X (Electronic)
IS  - 1744-859X (Linking)
VI  - 16
DP  - 2017
TI  - HLA DRB1*03 as a possible common etiology of schizophrenia, Graves' disease, and 
      type 2 diabetes.
PG  - 7
LID - 10.1186/s12991-017-0128-4 [doi]
LID - 7
AB  - BACKGROUND: Autoimmune diseases and schizophrenia share many common features. 
      Association studies confirm a shared genetic association in the human leukocyte 
      antigen (HLA) region between schizophrenia and most autoimmune diseases. To our 
      knowledge, the simultaneous syndromes of Graves' disease (GD) and type 2 diabetes 
      (T2D) in schizophrenia are rare in Tunisia. CASE PRESENTATION: We report a case 
      of a 42-year-old woman admitted to the department of psychiatry for an acute 
      relapse of chronic schizophrenia. Her medical history revealed that she was 
      followed for Graves' disease and for a type 2 diabetes mellitus. A low-resolution 
      HLA typing was performed by polymerase chain reaction sequence-specific primer 
      (PCR-SSP) techniques according to determine the patient's haplotype. CONCLUSIONS: 
      Our study suggests that the HLA DRB1*03 allele may explain a common etiology 
      underlying the co-morbidity of Graves' disease, type 2 diabetes, and 
      schizophrenia in our patient.
FAU - Sayeh, Aicha
AU  - Sayeh A
AD  - Laboratoire de Biologie Moleculaire, Service d'Hematologie., Hopital Militaire de 
      Tunis, Montfleury, 1008 Tunis, Tunisia.
AD  - Faculte des Sciences de Tunis, Universite Tunis el Manar, 2092 Tunis, Tunisia. 
      ISNI: 0000 0001 2177 9066. GRID: grid.265234.4
FAU - Ben Cheikh, Cheker
AU  - Ben Cheikh C
AD  - Service de Psychiatrie, Hopital Militaire de Tunis, Montfleury, 1008 Tunis, 
      Tunisia.
AD  - Faculte de Medecine de Tunis, Universite de Tunis El Manar, 1007 Tunis, Tunisia. 
      ISNI: 0000000122959819. GRID: grid.12574.35
FAU - Mardessi, Ali
AU  - Mardessi A
AD  - Faculte de Medecine de Tunis, Universite de Tunis El Manar, 1007 Tunis, Tunisia. 
      ISNI: 0000000122959819. GRID: grid.12574.35
AD  - Service Oto-rhino-laryngologie, Hopital Militaire de Tunis, Montfleury, 1008 
      Tunis, Tunisia.
FAU - Mrad, Meriem
AU  - Mrad M
AD  - Laboratoire de Biologie Moleculaire, Service d'Hematologie., Hopital Militaire de 
      Tunis, Montfleury, 1008 Tunis, Tunisia.
AD  - Faculte des Sciences de Tunis, Universite Tunis el Manar, 2092 Tunis, Tunisia. 
      ISNI: 0000 0001 2177 9066. GRID: grid.265234.4
FAU - Nsiri, Brahim
AU  - Nsiri B
AD  - Laboratoire de Biologie Moleculaire, Service d'Hematologie., Hopital Militaire de 
      Tunis, Montfleury, 1008 Tunis, Tunisia.
FAU - Oumaya, Abdelaziz
AU  - Oumaya A
AD  - Service de Psychiatrie, Hopital Militaire de Tunis, Montfleury, 1008 Tunis, 
      Tunisia.
AD  - Faculte de Medecine de Tunis, Universite de Tunis El Manar, 1007 Tunis, Tunisia. 
      ISNI: 0000000122959819. GRID: grid.12574.35
FAU - Fekih-Mrissa, Najiba
AU  - Fekih-Mrissa N
AD  - Laboratoire de Biologie Moleculaire, Service d'Hematologie., Hopital Militaire de 
      Tunis, Montfleury, 1008 Tunis, Tunisia.
AD  - Academie Militaire Fondouk Jedid, 8012 Nabeul, Tunisia.
LA  - eng
PT  - Case Reports
DEP - 20170202
PL  - England
TA  - Ann Gen Psychiatry
JT  - Annals of general psychiatry
JID - 101236515
PMC - PMC5290670
OTO - NOTNLM
OT  - Autoimmunity
OT  - Graves' disease
OT  - HLA
OT  - Schizophrenia
OT  - Type 2 diabetes
EDAT- 2017/02/09 06:00
MHDA- 2017/02/09 06:01
PMCR- 2017/02/02
CRDT- 2017/02/09 06:00
PHST- 2016/09/22 00:00 [received]
PHST- 2017/01/12 00:00 [accepted]
PHST- 2017/02/09 06:00 [entrez]
PHST- 2017/02/09 06:00 [pubmed]
PHST- 2017/02/09 06:01 [medline]
PHST- 2017/02/02 00:00 [pmc-release]
AID - 128 [pii]
AID - 10.1186/s12991-017-0128-4 [doi]
PST - epublish
SO  - Ann Gen Psychiatry. 2017 Feb 2;16:7. doi: 10.1186/s12991-017-0128-4. eCollection 
      2017.