PMID- 28176268 OWN - NLM STAT- MEDLINE DCOM- 20180205 LR - 20220129 IS - 1866-6647 (Electronic) IS - 1866-6116 (Print) IS - 1866-6116 (Linking) VI - 9 IP - 2 DP - 2017 Jun TI - No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease in nine ADHD candidate SNPs. PG - 121-127 LID - 10.1007/s12402-017-0219-8 [doi] AB - Attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease (PD) involve pathological changes in brain structures such as the basal ganglia, which are essential for the control of motor and cognitive behavior and impulsivity. The cause of ADHD and PD remains unknown, but there is increasing evidence that both seem to result from a complicated interplay of genetic and environmental factors affecting numerous cellular processes and brain regions. To explore the possibility of common genetic pathways within the respective pathophysiologies, nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls: one variant, respectively, in the genes coding for synaptosomal-associated protein 25 k (SNAP25), the dopamine (DA) transporter (SLC6A3; DAT1), DA receptor D4 (DRD4), serotonin receptor 1B (HTR1B), tryptophan hydroxylase 2 (TPH2), the norepinephrine transporter SLC6A2 and three SNPs in cadherin 13 (CDH13). Information was extracted from a recent meta-analysis of five genome-wide association studies, in which 7,689,524 SNPs in European samples were successfully imputed. No significant association was observed after correction for multiple testing. Therefore, it is reasonable to conclude that candidate variants implicated in the pathogenesis of ADHD do not play a substantial role in PD. FAU - Geissler, Julia M AU - Geissler JM AUID- ORCID: 0000-0003-1878-9647 AD - Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Wurzburg, Margarete-Hoppel-Platz 1, 97080, Wurzburg, Germany. Geissler_J@ukw.de. CN - International Parkinson Disease Genomics Consortium members FAU - Romanos, Marcel AU - Romanos M AD - Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Wurzburg, Margarete-Hoppel-Platz 1, 97080, Wurzburg, Germany. FAU - Gerlach, Manfred AU - Gerlach M AD - Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Wurzburg, Margarete-Hoppel-Platz 1, 97080, Wurzburg, Germany. FAU - Berg, Daniela AU - Berg D AD - Department of Neurodegeneration, Hertie-Institute of Clinical Brain Research, University of Tubingen, Tubingen, Germany. AD - DZNE-German Center for Neurodegenerative Diseases, University of Tubingen, Tubingen, Germany. AD - Department of Neurology, Christian-Albrechts-University, Kiel, Germany. FAU - Schulte, Claudia AU - Schulte C AD - Department of Neurodegeneration, Hertie-Institute of Clinical Brain Research, University of Tubingen, Tubingen, Germany. AD - DZNE-German Center for Neurodegenerative Diseases, University of Tubingen, Tubingen, Germany. LA - eng GR - ZIA AG000933-03/Intramural NIH HHS/United States GR - G-0907/PUK_/Parkinson's UK/United Kingdom GR - R01 NS075321/NS/NINDS NIH HHS/United States GR - J-0901/PUK_/Parkinson's UK/United Kingdom GR - Wellcome Trust/United Kingdom GR - G0701075/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Meta-Analysis PT - Multicenter Study DEP - 20170207 PL - Austria TA - Atten Defic Hyperact Disord JT - Attention deficit and hyperactivity disorders JID - 101491944 SB - IM MH - Attention Deficit Disorder with Hyperactivity/*genetics MH - *Genetic Association Studies MH - Genetic Predisposition to Disease/genetics MH - Humans MH - Parkinson Disease/*genetics MH - Polymorphism, Single Nucleotide/genetics PMC - PMC6233883 MID - NIHMS940138 OTO - NOTNLM OT - ADHD OT - CDH13 OT - Dopamine transporter OT - GWAS OT - Parkinson's disease OT - SNPs COIS- Conflict of interest On behalf of all authors, the corresponding author states that there is no conflict of interest. FIR - Nalls, Mike IR - Nalls M FIR - Plagnol, Vincent IR - Plagnol V FIR - Hernandez, Dena G IR - Hernandez DG FIR - Sharma, Manu IR - Sharma M FIR - Sheerin, Una-Marie IR - Sheerin UM FIR - Saad, Mohamad IR - Saad M FIR - Simon-Sanchez, Javier IR - Simon-Sanchez J FIR - Schulte, Claudia IR - Schulte C FIR - Lesage, Suzanne IR - Lesage S FIR - Sveinbjornsdottir, Sigurlaug IR - Sveinbjornsdottir S FIR - Arepalli, Sampath IR - Arepalli S FIR - Barker, Roger IR - Barker R FIR - Ben-Shlomo, Yoav IR - Ben-Shlomo Y FIR - Berendse, Henk W IR - Berendse HW FIR - Berg, Daniela IR - Berg D FIR - Bhatia, Kailash IR - Bhatia K FIR - de Bie, Rob M A IR - de Bie RMA FIR - Biffi, Alessandro IR - Biffi A FIR - Bloem, Bas IR - Bloem B FIR - Bochdanovits, Zoltan IR - Bochdanovits Z FIR - Bonin, Michael IR - Bonin M FIR - Bras, Jose M IR - Bras JM FIR - Brockmann, Kathrin IR - Brockmann K FIR - Brooks, Janet IR - Brooks J FIR - Burn, David J IR - Burn DJ FIR - Charlesworth, Gavin IR - Charlesworth G FIR - Chen, Honglei IR - Chen H FIR - Chinnery, Patrick F IR - Chinnery PF FIR - Chong, Sean IR - Chong S FIR - Clarke, Carl E IR - Clarke CE FIR - Cookson, Mark R IR - Cookson MR FIR - Cooper, J Mark IR - Cooper JM FIR - Corvol, Jean Christophe IR - Corvol JC FIR - Counsell, Carl IR - Counsell C FIR - Damier, Philippe IR - Damier P FIR - Dartigues, Jean-Francois IR - Dartigues JF FIR - Deloukas, Panos IR - Deloukas P FIR - Deuschl, Gunther IR - Deuschl G FIR - Dexter, David T IR - Dexter DT FIR - van Dijk, Karin D IR - van Dijk KD FIR - Dillman, Allissa IR - Dillman A FIR - Durif, Frank IR - Durif F FIR - Durr, Alexandra IR - Durr A FIR - Edkins, Sarah IR - Edkins S FIR - Evans, Jonathan R IR - Evans JR FIR - Foltynie, Thomas IR - Foltynie T FIR - Gao, Jianjun IR - Gao J FIR - Gardner, Michelle IR - Gardner M FIR - Gibbs, J Raphael IR - Gibbs JR FIR - Goate, Alison IR - Goate A FIR - Gray, Emma IR - Gray E FIR - Guerreiro, Rita IR - Guerreiro R FIR - Gustafsson, Omar IR - Gustafsson O FIR - Harris, Clare IR - Harris C FIR - van Hilten, Jacobus J IR - van Hilten JJ FIR - Hofman, Albert IR - Hofman A FIR - Hollenbeck, Albert IR - Hollenbeck A FIR - Holton, Janice IR - Holton J FIR - Hu, Michele IR - Hu M FIR - Huang, Xuemei IR - Huang X FIR - Huber, Heiko IR - Huber H FIR - Hudson, Gavin IR - Hudson G FIR - Hunt, Sarah E IR - Hunt SE FIR - Huttenlocher, Johanna IR - Huttenlocher J FIR - Illig, Thomas IR - Illig T FIR - Jonsson, Palmi V IR - Jonsson PV FIR - Lambert, Jean-Charles IR - Lambert JC FIR - Langford, Cordelia IR - Langford C FIR - Lees, Andrew IR - Lees A FIR - Lichtner, Peter IR - Lichtner P FIR - Limousin, Patricia IR - Limousin P FIR - Lopez, Grisel IR - Lopez G FIR - Lorenz, Delia IR - Lorenz D FIR - McNeill, Alisdair IR - McNeill A FIR - Moorby, Catriona IR - Moorby C FIR - Moore, Matthew IR - Moore M FIR - Morris, Huw R IR - Morris HR FIR - Morrison, Karen E IR - Morrison KE FIR - Mudanohwo, Ese IR - Mudanohwo E FIR - O'Sullivan, Sean S IR - O'Sullivan SS FIR - Pearson, Justin IR - Pearson J FIR - Perlmutter, Joel S IR - Perlmutter JS FIR - Petursson, Hjorvar IR - Petursson H FIR - Pollak, Pierre IR - Pollak P FIR - Post, Bart IR - Post B FIR - Potter, Simon IR - Potter S FIR - Ravina, Bernard IR - Ravina B FIR - Revesz, Tamas IR - Revesz T FIR - Riess, Olaf IR - Riess O FIR - Rivadeneira, Fernando IR - Rivadeneira F FIR - Rizzu, Patrizia IR - Rizzu P FIR - Ryten, Mina IR - Ryten M FIR - Sawcer, Stephen IR - Sawcer S FIR - Schapira, Anthony IR - Schapira A FIR - Scheffer, Hans IR - Scheffer H FIR - Shaw, Karen IR - Shaw K FIR - Shoulson, Ira IR - Shoulson I FIR - Sidransky, Ellen IR - Sidransky E FIR - Smith, Colin IR - Smith C FIR - Spencer, Chris C A IR - Spencer CCA FIR - Stefansson, Hreinn IR - Stefansson H FIR - Steinberg, Stacy IR - Steinberg S FIR - Stockton, Joanna D IR - Stockton JD FIR - Strange, Amy IR - Strange A FIR - Talbot, Kevin IR - Talbot K FIR - Tanner, Carlie M IR - Tanner CM FIR - Tashakkori-Ghanbaria, Avazeh IR - Tashakkori-Ghanbaria A FIR - Tison, Francois IR - Tison F FIR - Trabzuni, Daniah IR - Trabzuni D FIR - Traynor, Bryan J IR - Traynor BJ FIR - Uitterlinden, Andre G IR - Uitterlinden AG FIR - Velseboer, Daan IR - Velseboer D FIR - Vidailhet, Marie IR - Vidailhet M FIR - Walker, Robert IR - Walker R FIR - van de Warrenburg, Bart IR - van de Warrenburg B FIR - Wickremaratchi, Mirdhu IR - Wickremaratchi M FIR - Williams, Nigel IR - Williams N FIR - Williams-Gray, Caroline H IR - Williams-Gray CH FIR - Winder-Rhodes, Sophie IR - Winder-Rhodes S FIR - Stefansson, Kari IR - Stefansson K FIR - Martinez, Maria IR - Martinez M FIR - Hardy, John IR - Hardy J FIR - Heutink, Peter IR - Heutink P FIR - Brice, Alexis IR - Brice A FIR - Gasser, Thomas IR - Gasser T FIR - Singleton, Andrew B IR - Singleton AB FIR - Wood, Nicholas W IR - Wood NW EDAT- 2017/02/09 06:00 MHDA- 2018/02/06 06:00 PMCR- 2018/11/13 CRDT- 2017/02/09 06:00 PHST- 2016/04/01 00:00 [received] PHST- 2017/01/18 00:00 [accepted] PHST- 2017/02/09 06:00 [pubmed] PHST- 2018/02/06 06:00 [medline] PHST- 2017/02/09 06:00 [entrez] PHST- 2018/11/13 00:00 [pmc-release] AID - 10.1007/s12402-017-0219-8 [pii] AID - 10.1007/s12402-017-0219-8 [doi] PST - ppublish SO - Atten Defic Hyperact Disord. 2017 Jun;9(2):121-127. doi: 10.1007/s12402-017-0219-8. Epub 2017 Feb 7.