PMID- 28176354
OWN - NLM
STAT- MEDLINE
DCOM- 20171221
LR  - 20181202
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 118
IP  - 9
DP  - 2017 Sep
TI  - Pretreatment of Mesenchymal Stem Cells With Leishmania major Soluble Antigens 
      Induce Anti-Inflammatory Properties in Mouse Peritoneal Macrophages.
PG  - 2764-2779
LID - 10.1002/jcb.25926 [doi]
AB  - Recent studies have demonstrated the influential role of microbial stimulus in 
      characteristics and immunomodulatory effects of mesenchymal stem cells (MSCs). 
      Due to the migration of MSCs to infection site, it is of importance to understand 
      the interaction of microbial ligands with MSCs in order to clarify the positive 
      or negative role of MSCs in the control of infection. In this research, we assess 
      leishmanial soluble antigen (LSA)-primed MSCs on macrophage immune responses to 
      lipopolysaccharide (LPS). For this purpose, the effects of both conditioned media 
      (CM) and cell-cell contact of LSA primed MSCs were determined on macrophage 
      responses to LPS. According to the obtained results, MSC-treated macrophages 
      demonstrated an alternatively activated macrophages with higher levels of 
      interleukin-10 (IL-10) and transforming growth factor-alpha (TNF-alpha) and lower 
      levels of IL-6 and nitric oxide (NO) production as compared to the controls. In 
      addition, phagocytosis of apoptotic thymocytes was induced in MSC-treated 
      macrophages. In conclusion, it seems that MSCs trigger an anti-inflammatory 
      phenotype in macrophages at Leishmania infected sites in order to enhance the 
      induction of immune regulatory cells and clearance of apoptotic cells. J. Cell. 
      Biochem. 118: 2764-2779, 2017. (c) 2017 Wiley Periodicals, Inc.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Khosrowpour, Zahra
AU  - Khosrowpour Z
AD  - Department of Immunology, School of Medicine, Shahid Beheshti University of 
      Medical Sciences, Tehran, Iran.
FAU - Hashemi, Seyed Mahmoud
AU  - Hashemi SM
AUID- ORCID: 0000-0003-1389-5803
AD  - Department of Immunology, School of Medicine, Shahid Beheshti University of 
      Medical Sciences, Tehran, Iran.
AD  - Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, 
      Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Mohammadi-Yeganeh, Samira
AU  - Mohammadi-Yeganeh S
AD  - Cellular and Molecular Biology Research Center, Shahid Beheshti University of 
      Medical Sciences, Tehran, Iran.
AD  - Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid 
      Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Soudi, Sara
AU  - Soudi S
AD  - Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares 
      University, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20170427
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (Antigens, Protozoan)
RN  - 0 (IL10 protein, mouse)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (interleukin-6, mouse)
RN  - 130068-27-8 (Interleukin-10)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Animals
MH  - Antigens, Protozoan/*immunology
MH  - Inflammation/immunology
MH  - Interleukin-10/immunology
MH  - Interleukin-6/immunology
MH  - Leishmania major/*immunology
MH  - Macrophages, Peritoneal/*immunology
MH  - Mesenchymal Stem Cells/*immunology
MH  - Mice
MH  - Nitric Oxide/immunology
MH  - Tumor Necrosis Factor-alpha/immunology
OTO - NOTNLM
OT  - ANTI-INFLAMMATORY
OT  - LEISHMANIA MAJOR SOLUBLE ANTIGENS
OT  - MESENCHYMAL STEM CELLS
OT  - MOUSE
OT  - PERITONEAL MACROPHAGES
EDAT- 2017/02/09 06:00
MHDA- 2017/12/22 06:00
CRDT- 2017/02/09 06:00
PHST- 2016/12/05 00:00 [received]
PHST- 2017/02/06 00:00 [accepted]
PHST- 2017/02/09 06:00 [pubmed]
PHST- 2017/12/22 06:00 [medline]
PHST- 2017/02/09 06:00 [entrez]
AID - 10.1002/jcb.25926 [doi]
PST - ppublish
SO  - J Cell Biochem. 2017 Sep;118(9):2764-2779. doi: 10.1002/jcb.25926. Epub 2017 Apr 
      27.