PMID- 28177762
OWN - NLM
STAT- MEDLINE
DCOM- 20170815
LR  - 20220316
IS  - 1208-6002 (Electronic)
IS  - 0829-8211 (Linking)
VI  - 95
IP  - 3
DP  - 2017 Jun
TI  - Chronic intermittent hypoxia disturbs insulin secretion and causes pancreatic 
      injury via the MAPK signaling pathway.
PG  - 415-420
LID - 10.1139/bcb-2016-0167 [doi]
AB  - Obstructive sleep apnea (OSA) is a breathing disorder during sleep, with a most 
      prominent character of chronic intermittent hypoxia (CIH), which induces the 
      generation of reactive oxygen species (ROS) that damages multiple tissues and 
      causes metabolic disorders. In this study, we established a rat model of varying 
      OSA with different grades of CIH (12.5% O(2), 10% O(2), 7.5% O(2), and 5% O(2)) 
      for 12 weeks, and found that CIH stimulated insulin secretion, reduced the 
      insulin:proinsulin ratio in pancreatic tissue, and caused pancreatic tissue 
      lesions and cell apoptosis in a dose-dependent manner. Moreover, CIH promoted the 
      production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6, and 
      activated mitogen-activated protein kinase (MAPK) family members, extracellular 
      regulated protein kinase (ERK), c-Jun N-terminal kinase (JNK), and P38, depending 
      on the O(2) concentration. In summary, CIH disturbed insulin secretion, and 
      caused inflammation, lesions, and cell apoptosis in pancreatic tissue via the 
      MAPK signaling pathway, which may be of great significance for clinical treatment 
      of OSA and type 2 diabetes mellitus (T2DM).
FAU - Wang, Yeying
AU  - Wang Y
AD  - a Department of Respiratory Medicine, The Second Affiliated Hospital of Kunming 
      Medical University, Kunming, Yunnan 650101, People's Republic of China.
AD  - b Department of Epidemiology and Biostatistics, School of Public Health, Kunming 
      Medical University, Kunming, Yunnan 650500, People's Republic of China.
FAU - Hai, Bing
AU  - Hai B
AD  - a Department of Respiratory Medicine, The Second Affiliated Hospital of Kunming 
      Medical University, Kunming, Yunnan 650101, People's Republic of China.
FAU - Niu, Xiaoqun
AU  - Niu X
AD  - a Department of Respiratory Medicine, The Second Affiliated Hospital of Kunming 
      Medical University, Kunming, Yunnan 650101, People's Republic of China.
FAU - Ai, Li
AU  - Ai L
AD  - a Department of Respiratory Medicine, The Second Affiliated Hospital of Kunming 
      Medical University, Kunming, Yunnan 650101, People's Republic of China.
FAU - Cao, Yu
AU  - Cao Y
AD  - a Department of Respiratory Medicine, The Second Affiliated Hospital of Kunming 
      Medical University, Kunming, Yunnan 650101, People's Republic of China.
FAU - Li, Ran
AU  - Li R
AD  - a Department of Respiratory Medicine, The Second Affiliated Hospital of Kunming 
      Medical University, Kunming, Yunnan 650101, People's Republic of China.
FAU - Li, Yongxia
AU  - Li Y
AD  - a Department of Respiratory Medicine, The Second Affiliated Hospital of Kunming 
      Medical University, Kunming, Yunnan 650101, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20161128
PL  - Canada
TA  - Biochem Cell Biol
JT  - Biochemistry and cell biology = Biochimie et biologie cellulaire
JID - 8606068
RN  - 0 (Insulin)
RN  - 0 (Interleukin-6)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Diabetes Mellitus, Type 2/*etiology/pathology
MH  - Hypoxia/*physiopathology
MH  - Inflammation/etiology/pathology
MH  - Insulin/*metabolism
MH  - Insulin Resistance
MH  - Insulin Secretion
MH  - Interleukin-6/metabolism
MH  - JNK Mitogen-Activated Protein Kinases/*metabolism
MH  - MAP Kinase Signaling System
MH  - Male
MH  - Pancreas/injuries/metabolism/*pathology
MH  - Rats
MH  - Rats, Wistar
MH  - Reactive Oxygen Species/metabolism
MH  - Sleep Apnea, Obstructive/*complications
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - p38 Mitogen-Activated Protein Kinases/*metabolism
OTO - NOTNLM
OT  - MAPK
OT  - apnee obstructive du sommeil
OT  - chronic intermittent hypoxia
OT  - hypoxie intermittente chronique
OT  - insulin
OT  - insuline
OT  - obstructive sleep apnea
OT  - pancreas
OT  - pancreas
EDAT- 2017/02/09 06:00
MHDA- 2017/08/16 06:00
CRDT- 2017/02/09 06:00
PHST- 2017/02/09 06:00 [pubmed]
PHST- 2017/08/16 06:00 [medline]
PHST- 2017/02/09 06:00 [entrez]
AID - 10.1139/bcb-2016-0167 [doi]
PST - ppublish
SO  - Biochem Cell Biol. 2017 Jun;95(3):415-420. doi: 10.1139/bcb-2016-0167. Epub 2016 
      Nov 28.