PMID- 2817828
OWN - NLM
STAT- MEDLINE
DCOM- 19891130
LR  - 20220228
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 26
IP  - 4
DP  - 1989 Oct
TI  - Tropical spastic paraparesis: a model of virus-induced, cytotoxic T-cell-mediated 
      demyelination?
PG  - 523-30
AB  - Tropical spastic paraparesis is a neurological disorder that is most commonly 
      seen in certain tropical (mainly Caribbean) areas and that presents as a 
      progressive spastic paraparesis and urinary dysfunction. Recent studies have 
      revealed an association between tropical spastic paraparesis and human T-cell 
      lymphotropic virus type I (HTLV-I) infection. We report the results of a detailed 
      morphological and immunocytochemical study of a patient with tropical spastic 
      paraparesis. Lesions were restricted to the spinal cord and optic nerve, where 
      demyelination, inflammation, and fiber loss were common features. Lymphocytes 
      were seen closely applied to nerve fibers within which were changes resembling 
      those seen in myelinated central nervous system cultures exposed to cytokines. 
      Immunocytochemically, HTLV-I p19 core protein and a predominance of CD8+ 
      (suppressor/cytotoxic) T cells and expression of class I major histocompatibility 
      antigen were demonstrated in spinal cord lesions. It is postulated that cytotoxic 
      T cells, either directly or via cytokines, induce lysis of the myelin sheath and 
      subsequently the axon, resulting in a mixed picture of demyelination and axonal 
      loss with secondary tractal degeneration. Despite this destruction, extensive 
      remyelination was evident within affected areas of spinal cord.
FAU - Moore, G R
AU  - Moore GR
AD  - Department of Pathology (Neuropathology), Albert Einstein College of Medicine, 
      Bronx, NY.
FAU - Traugott, U
AU  - Traugott U
FAU - Scheinberg, L C
AU  - Scheinberg LC
FAU - Raine, C S
AU  - Raine CS
LA  - eng
GR  - NS 07098/NS/NINDS NIH HHS/United States
GR  - NS 08952/NS/NINDS NIH HHS/United States
GR  - NS 11920/NS/NINDS NIH HHS/United States
GR  - etc.
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
SB  - IM
MH  - Female
MH  - HTLV-I Infections/*complications/immunology
MH  - Humans
MH  - Middle Aged
MH  - Paraparesis, Tropical Spastic/immunology/*microbiology/pathology
MH  - T-Lymphocytes, Cytotoxic/*immunology
EDAT- 1989/10/01 00:00
MHDA- 1989/10/01 00:01
CRDT- 1989/10/01 00:00
PHST- 1989/10/01 00:00 [pubmed]
PHST- 1989/10/01 00:01 [medline]
PHST- 1989/10/01 00:00 [entrez]
AID - 10.1002/ana.410260405 [doi]
PST - ppublish
SO  - Ann Neurol. 1989 Oct;26(4):523-30. doi: 10.1002/ana.410260405.